FGOP2_MOUSE
ID FGOP2_MOUSE Reviewed; 253 AA.
AC Q9CRA9; Q3TEX1; Q3TW81; Q9D7R0;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=FGFR1 oncogene partner 2 homolog;
GN Name=Fgfr1op2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, Cerebellum, Lung, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in wound healing pathway. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CRA9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CRA9-2; Sequence=VSP_027541;
CC -!- SIMILARITY: Belongs to the SIKE family. {ECO:0000305}.
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DR EMBL; AK004662; BAB23452.1; -; mRNA.
DR EMBL; AK005320; BAB23951.1; -; mRNA.
DR EMBL; AK008983; BAB26006.1; -; mRNA.
DR EMBL; AK151318; BAE30299.1; -; mRNA.
DR EMBL; AK152617; BAE31360.1; -; mRNA.
DR EMBL; AK153137; BAE31749.1; -; mRNA.
DR EMBL; AK159805; BAE35385.1; -; mRNA.
DR EMBL; AK169380; BAE41127.1; -; mRNA.
DR EMBL; AK169383; BAE41130.1; -; mRNA.
DR EMBL; BC028876; AAH28876.1; -; mRNA.
DR CCDS; CCDS39711.1; -. [Q9CRA9-1]
DR CCDS; CCDS85186.1; -. [Q9CRA9-2]
DR RefSeq; NP_001334442.1; NM_001347513.1. [Q9CRA9-2]
DR RefSeq; NP_080494.1; NM_026218.2. [Q9CRA9-1]
DR AlphaFoldDB; Q9CRA9; -.
DR SMR; Q9CRA9; -.
DR BioGRID; 212252; 5.
DR STRING; 10090.ENSMUSP00000107292; -.
DR iPTMnet; Q9CRA9; -.
DR PhosphoSitePlus; Q9CRA9; -.
DR EPD; Q9CRA9; -.
DR jPOST; Q9CRA9; -.
DR MaxQB; Q9CRA9; -.
DR PaxDb; Q9CRA9; -.
DR PRIDE; Q9CRA9; -.
DR ProteomicsDB; 270984; -. [Q9CRA9-1]
DR ProteomicsDB; 270985; -. [Q9CRA9-2]
DR Antibodypedia; 24359; 222 antibodies from 24 providers.
DR Ensembl; ENSMUST00000067404; ENSMUSP00000098352; ENSMUSG00000040242. [Q9CRA9-2]
DR Ensembl; ENSMUST00000111663; ENSMUSP00000107292; ENSMUSG00000040242. [Q9CRA9-1]
DR GeneID; 67529; -.
DR KEGG; mmu:67529; -.
DR UCSC; uc009esc.1; mouse. [Q9CRA9-1]
DR UCSC; uc009esd.1; mouse. [Q9CRA9-2]
DR CTD; 26127; -.
DR MGI; MGI:1914779; Fgfr1op2.
DR VEuPathDB; HostDB:ENSMUSG00000040242; -.
DR eggNOG; ENOG502QSAD; Eukaryota.
DR GeneTree; ENSGT00390000018003; -.
DR InParanoid; Q9CRA9; -.
DR OMA; DHENTAD; -.
DR OrthoDB; 1368908at2759; -.
DR PhylomeDB; Q9CRA9; -.
DR TreeFam; TF324337; -.
DR BioGRID-ORCS; 67529; 1 hit in 56 CRISPR screens.
DR ChiTaRS; Fgfr1op2; mouse.
DR PRO; PR:Q9CRA9; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9CRA9; protein.
DR Bgee; ENSMUSG00000040242; Expressed in ascending aorta and 263 other tissues.
DR ExpressionAtlas; Q9CRA9; baseline and differential.
DR Genevisible; Q9CRA9; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR GO; GO:0009611; P:response to wounding; IBA:GO_Central.
DR GO; GO:0042060; P:wound healing; IMP:MGI.
DR InterPro; IPR008555; SIKE.
DR PANTHER; PTHR12186; PTHR12186; 1.
DR Pfam; PF05769; SIKE; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..253
FT /note="FGFR1 oncogene partner 2 homolog"
FT /id="PRO_0000299042"
FT REGION 231..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 5..104
FT /evidence="ECO:0000255"
FT COILED 160..223
FT /evidence="ECO:0000255"
FT MOD_RES 140
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 133..170
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_027541"
FT CONFLICT 108
FT /note="M -> V (in Ref. 1; BAE35385)"
FT /evidence="ECO:0000305"
FT CONFLICT 211
FT /note="N -> D (in Ref. 1; BAE41127)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 253 AA; 29374 MW; 07A077BAB5071119 CRC64;
MSCTIEKALA DAKALVERLR DHDDAAESLI EQTTALSKRV EAMKQYQEEI QELNEVARHR
PRSTLVMGIQ QENRQIRELQ QENKELRTSL EEHQSALELI MSKYREQMFR LLMASKKDDP
GIIMKLKEQH SKIDMVHRNS CEGFFLDASR HILEAPQHGL ERRHLEANQN ELQAHVDQIT
EMAAVMRKAI EIDEQQGCKE QERIFQLEQE NKGLREILQI TRESFLNLRK DDASESTSLS
ALVTNSDLSL RKS
