ID   FGOP2_RAT               Reviewed;         253 AA.
AC   Q6TA25; Q5PPH1; Q6TA26;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 2.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=FGFR1 oncogene partner 2 homolog;
DE   AltName: Full=Wound-inducible transcript 3.0 protein;
DE            Short=Wit3.0;
GN   Name=Fgfr1op2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND INDUCTION.
RX   PubMed=12097305; DOI=10.1177/154405910208100402;
RA   Sukotjo C., Abanmy A.A., Ogawa T., Nishimura I.;
RT   "Molecular cloning of wound inducible transcript (wit 3.0) differentially
RT   expressed in edentulous oral mucosa undergoing tooth extraction wound-
RT   healing.";
RL   J. Dent. Res. 81:229-235(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=14527947; DOI=10.1074/jbc.m309616200;
RA   Sukotjo C., Lin A., Song K., Ogawa T., Wu B., Nishimura I.;
RT   "Oral fibroblast expression of wound-inducible transcript 3.0 (wit3.0)
RT   accelerates the collagen gel contraction in vitro.";
RL   J. Biol. Chem. 278:51527-51534(2003).
CC   -!- FUNCTION: May be involved in wound healing pathway underlying the
CC       favorable early wound closure characteristics of oral mucosa.
CC       Accelerates the collagen gel contraction in vitro.
CC       {ECO:0000269|PubMed:14527947}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=Beta;
CC         IsoId=Q6TA25-1; Sequence=Displayed;
CC       Name=2; Synonyms=Alpha;
CC         IsoId=Q6TA25-2; Sequence=VSP_027542;
CC   -!- INDUCTION: By wound, in oral mucosa undergoing tooth extraction.
CC       {ECO:0000269|PubMed:12097305}.
CC   -!- SIMILARITY: Belongs to the SIKE family. {ECO:0000305}.
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DR   EMBL; AY426739; AAR20448.1; -; mRNA.
DR   EMBL; AY426740; AAR20449.1; -; mRNA.
DR   EMBL; BC087696; AAH87696.1; -; mRNA.
DR   RefSeq; NP_958824.1; NM_201421.1. [Q6TA25-1]
DR   RefSeq; XP_006237750.1; XM_006237688.2. [Q6TA25-2]
DR   AlphaFoldDB; Q6TA25; -.
DR   SMR; Q6TA25; -.
DR   STRING; 10116.ENSRNOP00000039568; -.
DR   iPTMnet; Q6TA25; -.
DR   PhosphoSitePlus; Q6TA25; -.
DR   PaxDb; Q6TA25; -.
DR   Ensembl; ENSRNOT00000002476; ENSRNOP00000002476; ENSRNOG00000001811. [Q6TA25-2]
DR   GeneID; 362463; -.
DR   KEGG; rno:362463; -.
DR   UCSC; RGD:1303233; rat. [Q6TA25-1]
DR   CTD; 26127; -.
DR   RGD; 1303233; Fgfr1op2.
DR   VEuPathDB; HostDB:ENSRNOG00000001811; -.
DR   eggNOG; ENOG502QSAD; Eukaryota.
DR   GeneTree; ENSGT00390000018003; -.
DR   HOGENOM; CLU_073167_1_0_1; -.
DR   InParanoid; Q6TA25; -.
DR   OMA; DHENTAD; -.
DR   OrthoDB; 1368908at2759; -.
DR   PhylomeDB; Q6TA25; -.
DR   TreeFam; TF324337; -.
DR   PRO; PR:Q6TA25; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000001811; Expressed in thymus and 20 other tissues.
DR   Genevisible; Q6TA25; RN.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0009611; P:response to wounding; IEP:RGD.
DR   GO; GO:0042060; P:wound healing; ISO:RGD.
DR   InterPro; IPR008555; SIKE.
DR   PANTHER; PTHR12186; PTHR12186; 1.
DR   Pfam; PF05769; SIKE; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Cytoplasm; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..253
FT                   /note="FGFR1 oncogene partner 2 homolog"
FT                   /id="PRO_0000299044"
FT   REGION          231..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          5..104
FT                   /evidence="ECO:0000255"
FT   COILED          160..223
FT                   /evidence="ECO:0000255"
FT   MOD_RES         140
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CRA9"
FT   VAR_SEQ         133..170
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12097305"
FT                   /id="VSP_027542"
FT   CONFLICT        79
FT                   /note="L -> F (in Ref. 1; AAR20448/AAR20449)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        202
FT                   /note="E -> Q (in Ref. 1; AAR20448/AAR20449)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        229
FT                   /note="R -> Q (in Ref. 1; AAR20448/AAR20449)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   253 AA;  29374 MW;  07A077BAB5071119 CRC64;
     MSCTIEKALA DAKALVERLR DHDDAAESLI EQTTALSKRV EAMKQYQEEI QELNEVARHR
     PRSTLVMGIQ QENRQIRELQ QENKELRTSL EEHQSALELI MSKYREQMFR LLMASKKDDP
     GIIMKLKEQH SKIDMVHRNS CEGFFLDASR HILEAPQHGL ERRHLEANQN ELQAHVDQIT
     EMAAVMRKAI EIDEQQGCKE QERIFQLEQE NKGLREILQI TRESFLNLRK DDASESTSLS
     ALVTNSDLSL RKS