FGR15_CANAL
ID FGR15_CANAL Reviewed; 518 AA.
AC Q5AD13; A0A1D8PG61;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2017, sequence version 2.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Filamentous growth regulator 15;
DE AltName: Full=Caspofungin sensitivity protein 2;
GN Name=FGR15; Synonyms=CAS2; OrderedLocusNames=CAALFM_C200720CA;
GN ORFNames=CaO19.2054, CaO19.9601;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=12773383; DOI=10.1093/emboj/cdg256;
RA Uhl M.A., Biery M., Craig N., Johnson A.D.;
RT "Haploinsufficiency-based large-scale forward genetic analysis of
RT filamentous growth in the diploid human fungal pathogen C.albicans.";
RL EMBO J. 22:2668-2678(2003).
RN [5]
RP INDUCTION.
RX PubMed=15917516; DOI=10.1128/aac.49.6.2226-2236.2005;
RA Liu T.T., Lee R.E., Barker K.S., Lee R.E., Wei L., Homayouni R.,
RA Rogers P.D.;
RT "Genome-wide expression profiling of the response to azole, polyene,
RT echinocandin, and pyrimidine antifungal agents in Candida albicans.";
RL Antimicrob. Agents Chemother. 49:2226-2236(2005).
RN [6]
RP DISRUPTION PHENOTYPE.
RX PubMed=16552442; DOI=10.1371/journal.ppat.0020021;
RA Bruno V.M., Kalachikov S., Subaran R., Nobile C.J., Kyratsous C.,
RA Mitchell A.P.;
RT "Control of the C. albicans cell wall damage response by transcriptional
RT regulator Cas5.";
RL PLoS Pathog. 2:E21-E21(2006).
CC -!- FUNCTION: Probable transcription factor involved in the regulation of
CC filamentous growth. {ECO:0000269|PubMed:12773383}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- INDUCTION: Induced by caspofungin. {ECO:0000269|PubMed:15917516}.
CC -!- DISRUPTION PHENOTYPE: Affects filamentous growths and leads to
CC hypersensitivity to caspofungin. {ECO:0000269|PubMed:12773383,
CC ECO:0000269|PubMed:16552442}.
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DR EMBL; CP017624; AOW27124.1; -; Genomic_DNA.
DR RefSeq; XP_719503.2; XM_714410.2.
DR AlphaFoldDB; Q5AD13; -.
DR BioGRID; 1221845; 1.
DR STRING; 237561.Q5AD13; -.
DR PRIDE; Q5AD13; -.
DR GeneID; 3638882; -.
DR KEGG; cal:CAALFM_C200720CA; -.
DR CGD; CAL0000192685; FGR15.
DR VEuPathDB; FungiDB:C2_00720C_A; -.
DR eggNOG; ENOG502R8YW; Eukaryota.
DR HOGENOM; CLU_032145_0_0_1; -.
DR InParanoid; Q5AD13; -.
DR OrthoDB; 1361991at2759; -.
DR PRO; PR:Q5AD13; -.
DR Proteomes; UP000000559; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009267; P:cellular response to starvation; IMP:CGD.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0036180; P:filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR GO; GO:0036170; P:filamentous growth of a population of unicellular organisms in response to starvation; IMP:CGD.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..518
FT /note="Filamentous growth regulator 15"
FT /id="PRO_0000426063"
FT ZN_FING 374..406
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 518 AA; 59138 MW; 8F8524A50199073C CRC64;
MESTLSVSDE KLTNSSTALN NCGDNKESSQ VLTTANTTTD NQQVQPKSQH QQSASTEPLS
KERTNISLEN DLILVDPNQQ SKNTVSDSVQ DTTGVPSDHG KQQTIGDQIK ILISSNPLNI
EEYSSHLNRL ATILYEENFT SDFLVTLHYK ILQLMDELPK FVDLQNPLKS QLYTIIDKNF
DILIKLATNY KVMEVSTASI RFLTTVFMNL NYWEVYNLLN KKPVLYHFLN LIEFDLNDCY
TRFINDYQRF TYDKITQPTV KSRSRSKVTK KRKVKGDSDF AGSNTATATT SVTTPDANTS
HEGKQHRSEA FFSLNPDTSD HDKYVADVIS GANVQKRKFR PDVKLEHHRI IKKPQPAADK
LSTKSSNYDP DVIHECQLPS AEEPHKLCLR RFSRKYELIR HQETVHSKKK KLFKCFVCVK
QNPGVGPRIF TRHDTLAKHI RVNHKISGKE AKAEVAYSKK HAEVVEEGDI TVHVGRRKTK
VDFELRAHME KRKSSGDDTN YMETSDLESG EEEVTFNK
