FGR27_CANAL
ID FGR27_CANAL Reviewed; 787 AA.
AC Q59NX5; A0A1D8PNR1;
DT 22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Filamentous growth regulator 27;
GN Name=FGR27; OrderedLocusNames=CAALFM_C503680WA; ORFNames=CaO19.6680;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP FUNCTION.
RX PubMed=12773383; DOI=10.1093/emboj/cdg256;
RA Uhl M.A., Biery M., Craig N., Johnson A.D.;
RT "Haploinsufficiency-based large-scale forward genetic analysis of
RT filamentous growth in the diploid human fungal pathogen C.albicans.";
RL EMBO J. 22:2668-2678(2003).
RN [5]
RP DOMAIN.
RX PubMed=18629206; DOI=10.1002/cfg.492;
RA Maicas S., Moreno I., Nieto A., Gomez M., Sentandreu R., Valentin E.;
RT "In silico analysis for transcription factors with Zn(II)(2)C(6) binuclear
RT cluster DNA-binding domains in Candida albicans.";
RL Comp. Funct. Genomics 6:345-356(2005).
RN [6]
RP INDUCTION.
RX PubMed=22265407; DOI=10.1016/j.cell.2011.10.048;
RA Nobile C.J., Fox E.P., Nett J.E., Sorrells T.R., Mitrovich Q.M.,
RA Hernday A.D., Tuch B.B., Andes D.R., Johnson A.D.;
RT "A recently evolved transcriptional network controls biofilm development in
RT Candida albicans.";
RL Cell 148:126-138(2012).
RN [7]
RP FUNCTION.
RX PubMed=22359502; DOI=10.1371/journal.ppat.1002525;
RA Finkel J.S., Xu W., Huang D., Hill E.M., Desai J.V., Woolford C.A.,
RA Nett J.E., Taff H., Norice C.T., Andes D.R., Lanni F., Mitchell A.P.;
RT "Portrait of Candida albicans adherence regulators.";
RL PLoS Pathog. 8:E1002525-E1002525(2012).
CC -!- FUNCTION: Transcription factor involved in yeast cell adherence to
CC silicone substrate, filamentous growth, and biofilm formation.
CC {ECO:0000269|PubMed:12773383, ECO:0000269|PubMed:22359502}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC -!- INDUCTION: Induced during biofilm formation.
CC {ECO:0000269|PubMed:22265407}.
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DR EMBL; CP017627; AOW29779.1; -; Genomic_DNA.
DR RefSeq; XP_711432.1; XM_706340.1.
DR AlphaFoldDB; Q59NX5; -.
DR SMR; Q59NX5; -.
DR STRING; 237561.Q59NX5; -.
DR GeneID; 3646988; -.
DR KEGG; cal:CAALFM_C503680WA; -.
DR CGD; CAL0000198392; FGR27.
DR VEuPathDB; FungiDB:C5_03680W_A; -.
DR eggNOG; ENOG502QVYJ; Eukaryota.
DR HOGENOM; CLU_007695_1_0_1; -.
DR InParanoid; Q59NX5; -.
DR OMA; RDRIWKS; -.
DR OrthoDB; 665867at2759; -.
DR Proteomes; UP000000559; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0009267; P:cellular response to starvation; IMP:CGD.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0036180; P:filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR GO; GO:0036170; P:filamentous growth of a population of unicellular organisms in response to starvation; IMP:CGD.
DR GO; GO:1900189; P:positive regulation of cell adhesion involved in single-species biofilm formation; IMP:CGD.
DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IMP:CGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:CGD.
DR GO; GO:0044011; P:single-species biofilm formation on inanimate substrate; IMP:CGD.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00906; Fungal_trans; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 2: Evidence at transcript level;
KW Cell adhesion; Coiled coil; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..787
FT /note="Filamentous growth regulator 27"
FT /id="PRO_0000424864"
FT DNA_BIND 31..57
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 69..97
FT /evidence="ECO:0000255"
FT COMPBIAS 8..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 787 AA; 89732 MW; 7451575755F68D6C CRC64;
MSAPIVETKK ASKRRIRRIP DDQRQKVSSA CDNCKKRKFK CSGEKPCFEC SKKGHDCTYT
IIDKRSLRGE RMAKLKQKKD NNEKQRELVN EQIAQSSIIH PQITPVLPVP EYANVTYQDS
SHSTVSGNDS YHLSSSSSIP QNLPAIVLPD TLRDPNNRGI LTPGSTPNSV SSESSVSNVC
VPKSLQPLLS FPLENKNNLR HKSEEPDMDN NTNNVPKKGG ISNQEGKSAI LLVDKSGAFR
YMGETSPLSV LYEARGIFYE YVGSTKLTED LRGCPVTDKP LKITMKEAAP LPHPSERDVY
IERFKVNING AYFVFDMDKF YEEIVDKVYE NPNSDLVQEN RVLLYFVLAI GSTYKDFSER
NPQAEKGAHY FESGRLILRD LVEDSAMWCV LCHYLQFHYY ESILKKSTAL VHLTAAINYA
QSLGLHRNFV NEQFSKLTAE YEYRRKLFRS LYISDRISSV FIGRPLIIND YDWDDPARFK
NTNASVLPLD FNSKCHIELT RICTLVGRIV ANFYQDKMID VKKTKNLAIQ LRLWSKGLDP
ELAFGNVLNP SQISNNEDNG NTVILLGIHI LHLWAVMLLS RPFFMFEAIS KINPEMRKSF
EEEEELSKQL CQAATKASIL AIKLMNHYIN TTFHEIKRME CYVIITCCFY ASIILGITIL
NGTFEEAGYT ENDLMNSLKD AQYILSQFSV CNKGAERYSE INLDLISALV NRHKGKEVKP
VVDNWSCNLF NDFNFGDTSG QNDVQTMMDF QQFFVSSDLI QFEEITDGTS SLPFDYNNYN
LFFGDKL
