FGR41_CANAL
ID FGR41_CANAL Reviewed; 250 AA.
AC Q5AP52; A0A1D8PEV6;
DT 22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Filamentous growth regulator 41;
DE AltName: Full=GPI-anchored protein 35;
DE Flags: Precursor;
GN Name=FGR41; Synonyms=PGA35; OrderedLocusNames=CAALFM_C110400CA;
GN ORFNames=CaO19.12376, CaO19.4910;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=12773383; DOI=10.1093/emboj/cdg256;
RA Uhl M.A., Biery M., Craig N., Johnson A.D.;
RT "Haploinsufficiency-based large-scale forward genetic analysis of
RT filamentous growth in the diploid human fungal pathogen C.albicans.";
RL EMBO J. 22:2668-2678(2003).
RN [5]
RP PREDICTION OF GPI-ANCHOR.
RX PubMed=12845604; DOI=10.1002/yea.1007;
RA De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT "Genome-wide identification of fungal GPI proteins.";
RL Yeast 20:781-796(2003).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=20641015; DOI=10.1002/yea.1775;
RA Sorgo A.G., Heilmann C.J., Dekker H.L., Brul S., de Koster C.G., Klis F.M.;
RT "Mass spectrometric analysis of the secretome of Candida albicans.";
RL Yeast 27:661-672(2010).
RN [7]
RP FUNCTION.
RX PubMed=21496229; DOI=10.1186/1471-2164-12-192;
RA Chaudhuri R., Ansari F.A., Raghunandanan M.V., Ramachandran S.;
RT "FungalRV: adhesin prediction and immunoinformatics portal for human fungal
RT pathogens.";
RL BMC Genomics 12:192-192(2011).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=21622905; DOI=10.1128/ec.05011-11;
RA Sorgo A.G., Heilmann C.J., Dekker H.L., Bekker M., Brul S., de Koster C.G.,
RA de Koning L.J., Klis F.M.;
RT "Effects of fluconazole on the secretome, the wall proteome, and wall
RT integrity of the clinical fungus Candida albicans.";
RL Eukaryot. Cell 10:1071-1081(2011).
CC -!- FUNCTION: Putative adhesin which may be involved in cell adhesion and
CC virulence (By similarity). Involved in the regulation of filamentous
CC growth. {ECO:0000250, ECO:0000269|PubMed:21496229}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20641015,
CC ECO:0000269|PubMed:21622905}. Cell membrane {ECO:0000305}; Lipid-
CC anchor, GPI-anchor {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Affects yeast-to hyphal transition.
CC {ECO:0000269|PubMed:12773383}.
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DR EMBL; CP017623; AOW26669.1; -; Genomic_DNA.
DR RefSeq; XP_723592.1; XM_718499.2.
DR AlphaFoldDB; Q5AP52; -.
DR GeneID; 3634839; -.
DR KEGG; cal:CAALFM_C110400CA; -.
DR CGD; CAL0000194403; FGR41.
DR VEuPathDB; FungiDB:C1_10400C_A; -.
DR eggNOG; ENOG502TCQW; Eukaryota.
DR HOGENOM; CLU_068295_0_0_1; -.
DR InParanoid; Q5AP52; -.
DR OMA; TTDSWII; -.
DR OrthoDB; 1640208at2759; -.
DR PRO; PR:Q5AP52; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IDA:CGD.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0009267; P:cellular response to starvation; IMP:CGD.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0036180; P:filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR GO; GO:0036170; P:filamentous growth of a population of unicellular organisms in response to starvation; IMP:CGD.
PE 1: Evidence at protein level;
KW Cell adhesion; Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein;
KW Membrane; Reference proteome; Secreted; Signal; Virulence.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..231
FT /note="Filamentous growth regulator 41"
FT /id="PRO_0000424939"
FT PROPEP 232..250
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000424940"
FT REGION 99..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 231
FT /note="GPI-anchor amidated aspartate"
FT /evidence="ECO:0000255"
FT CARBOHYD 64
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 182
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 208
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 250 AA; 26401 MW; 25061284B3CAFAA2 CRC64;
MKISNLIPAY LLPFSLFCQV LGAPTNGKRG NVVVVKVKTT VQQTQTDIQT ISEATGTTTN
YLINTSTETF TRYTATVTST VYGVPHTYTT VATTPVSAAD VIPNSENEVK SSPTESPVEQ
ETSTSSTSVA TTTTPVAKNP VSSQETSTPT PVPPETTSTS SSLLSSSQQT TTLAQVSETA
INDTTESSGP TITGSVSSQT TDSWIIENIS TVTSDGTCFV NYDYYYATET DDAEETTTLT
STITTTVTLN
