FGRL1_HUMAN
ID FGRL1_HUMAN Reviewed; 504 AA.
AC Q8N441; B2RAU9; Q6PJN1; Q9BXN7; Q9H4D7;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Fibroblast growth factor receptor-like 1;
DE Short=FGF receptor-like protein 1;
DE AltName: Full=FGF homologous factor receptor;
DE AltName: Full=FGFR-like protein;
DE AltName: Full=Fibroblast growth factor receptor 5;
DE Short=FGFR-5;
DE Flags: Precursor;
GN Name=FGFRL1; Synonyms=FGFR5, FHFR; ORFNames=UNQ480/PRO943;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT GLN-362.
RC TISSUE=Cartilage;
RX PubMed=11031111; DOI=10.1006/geno.2000.6332;
RA Wiedemann M., Trueb B.;
RT "Characterization of a novel protein (FGFRL1) from human cartilage related
RT to FGF receptors.";
RL Genomics 69:275-279(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT GLN-362.
RX PubMed=11267671; DOI=10.1016/s0167-4781(00)00282-7;
RA Kim I., Moon S.-O., Yu K.-H., Kim U.-H., Koh G.Y.;
RT "A novel fibroblast growth factor receptor-5 preferentially expressed in
RT the pancreas.";
RL Biochim. Biophys. Acta 1518:152-156(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Aggarwal S., Xie M.-H., Foster J., Frantz G., Stinson J., Corpuz R.T.,
RA Simmons L., Hillan K., Yansura D.G., Vandlen R.L., Goddard A.D.,
RA Gurney A.L.;
RT "FHFR, a novel fibroblast growth factor receptor that uniquely binds the
RT fibroblast growth factor homologous factors.";
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-362.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PROTEIN SEQUENCE OF 25-39.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
RN [8]
RP TISSUE SPECIFICITY.
RX PubMed=11418238; DOI=10.1016/s0378-1119(01)00518-2;
RA Sleeman M., Fraser J., McDonald M., Yuan S., White D., Grandison P.,
RA Kumble K., Watson J.D., Murison J.G.;
RT "Identification of a new fibroblast growth factor receptor, FGFR5.";
RL Gene 271:171-182(2001).
RN [9]
RP SUBCELLULAR LOCATION.
RC TISSUE=Cartilage;
RX PubMed=12813049; DOI=10.1074/jbc.m300281200;
RA Trueb B., Zhuang L., Taeschler S., Wiedemann M.;
RT "Characterization of FGFRL1, a novel fibroblast growth factor (FGF)
RT receptor preferentially expressed in skeletal tissues.";
RL J. Biol. Chem. 278:33857-33865(2003).
CC -!- FUNCTION: Has a negative effect on cell proliferation. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with FGF2 with a low affinity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:12813049}; Single-
CC pass type I membrane protein {ECO:0000269|PubMed:12813049}.
CC Note=Predominantly localized in the plasma membrane but also detected
CC in the Golgi and in secretory vesicles.
CC -!- TISSUE SPECIFICITY: Expressed preferentially in cartilaginous tissues
CC and pancreas. Highly expressed in the liver, kidney, heart, brain and
CC skeletal muscle. Weakly expressed in the lung, small intestine and
CC spleen. {ECO:0000269|PubMed:11031111, ECO:0000269|PubMed:11267671,
CC ECO:0000269|PubMed:11418238}.
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DR EMBL; AJ277437; CAC14171.1; -; mRNA.
DR EMBL; AF279689; AAK26742.1; -; mRNA.
DR EMBL; AF312678; AAK15273.1; -; mRNA.
DR EMBL; AY358303; AAQ88670.1; -; mRNA.
DR EMBL; AK314365; BAG36996.1; -; mRNA.
DR EMBL; BC036769; AAH36769.1; -; mRNA.
DR CCDS; CCDS3344.1; -.
DR RefSeq; NP_001004356.1; NM_001004356.2.
DR RefSeq; NP_001004358.1; NM_001004358.1.
DR RefSeq; NP_068742.2; NM_021923.3.
DR RefSeq; XP_011511788.1; XM_011513486.1.
DR AlphaFoldDB; Q8N441; -.
DR SMR; Q8N441; -.
DR BioGRID; 119806; 59.
DR IntAct; Q8N441; 23.
DR MINT; Q8N441; -.
DR STRING; 9606.ENSP00000381498; -.
DR TCDB; 8.A.23.1.6; the basigin (basigin) family.
DR GlyConnect; 1240; 2 N-Linked glycans (1 site).
DR GlyGen; Q8N441; 4 sites, 2 N-linked glycans (1 site).
DR iPTMnet; Q8N441; -.
DR PhosphoSitePlus; Q8N441; -.
DR BioMuta; FGFRL1; -.
DR DMDM; 68052359; -.
DR jPOST; Q8N441; -.
DR MassIVE; Q8N441; -.
DR MaxQB; Q8N441; -.
DR PaxDb; Q8N441; -.
DR PeptideAtlas; Q8N441; -.
DR PRIDE; Q8N441; -.
DR ProteomicsDB; 71879; -.
DR Antibodypedia; 22198; 359 antibodies from 32 providers.
DR DNASU; 53834; -.
DR Ensembl; ENST00000264748.6; ENSP00000264748.6; ENSG00000127418.15.
DR Ensembl; ENST00000398484.6; ENSP00000381498.2; ENSG00000127418.15.
DR Ensembl; ENST00000504138.5; ENSP00000423091.1; ENSG00000127418.15.
DR Ensembl; ENST00000510644.6; ENSP00000425025.1; ENSG00000127418.15.
DR GeneID; 53834; -.
DR KEGG; hsa:53834; -.
DR MANE-Select; ENST00000510644.6; ENSP00000425025.1; NM_001004356.3; NP_001004356.1.
DR UCSC; uc003gcf.4; human.
DR CTD; 53834; -.
DR DisGeNET; 53834; -.
DR GeneCards; FGFRL1; -.
DR HGNC; HGNC:3693; FGFRL1.
DR HPA; ENSG00000127418; Low tissue specificity.
DR MalaCards; FGFRL1; -.
DR MIM; 605830; gene.
DR neXtProt; NX_Q8N441; -.
DR OpenTargets; ENSG00000127418; -.
DR PharmGKB; PA28132; -.
DR VEuPathDB; HostDB:ENSG00000127418; -.
DR eggNOG; KOG0200; Eukaryota.
DR GeneTree; ENSGT00940000156736; -.
DR HOGENOM; CLU_038830_1_0_1; -.
DR InParanoid; Q8N441; -.
DR OMA; WAQPRFT; -.
DR OrthoDB; 612548at2759; -.
DR PhylomeDB; Q8N441; -.
DR PathwayCommons; Q8N441; -.
DR Reactome; R-HSA-5658623; FGFRL1 modulation of FGFR1 signaling.
DR SignaLink; Q8N441; -.
DR BioGRID-ORCS; 53834; 13 hits in 1079 CRISPR screens.
DR ChiTaRS; FGFRL1; human.
DR GeneWiki; FGFRL1; -.
DR GenomeRNAi; 53834; -.
DR Pharos; Q8N441; Tbio.
DR PRO; PR:Q8N441; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8N441; protein.
DR Bgee; ENSG00000127418; Expressed in right uterine tube and 113 other tissues.
DR ExpressionAtlas; Q8N441; baseline and differential.
DR Genevisible; Q8N441; HS.
DR GO; GO:0044291; C:cell-cell contact zone; IDA:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0030133; C:transport vesicle; IDA:UniProtKB.
DR GO; GO:0017134; F:fibroblast growth factor binding; IBA:GO_Central.
DR GO; GO:0005007; F:fibroblast growth factor receptor activity; IDA:UniProtKB.
DR GO; GO:0008201; F:heparin binding; IDA:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IPI:UniProtKB.
DR GO; GO:0098742; P:cell-cell adhesion via plasma-membrane adhesion molecules; IMP:UniProtKB.
DR GO; GO:0060539; P:diaphragm development; IEA:Ensembl.
DR GO; GO:0003179; P:heart valve morphogenesis; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR GO; GO:0060412; P:ventricular septum morphogenesis; IEA:Ensembl.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR Pfam; PF07679; I-set; 2.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; SSF48726; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Glycoprotein;
KW Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 25..504
FT /note="Fibroblast growth factor receptor-like 1"
FT /id="PRO_0000021250"
FT TOPO_DOM 25..378
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 400..504
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 29..115
FT /note="Ig-like C2-type 1"
FT DOMAIN 147..237
FT /note="Ig-like C2-type 2"
FT DOMAIN 246..354
FT /note="Ig-like C2-type 3"
FT REGION 123..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 231
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 255
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 293
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 51..99
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 172..221
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 268..338
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VARIANT 362
FT /note="P -> Q (in dbSNP:rs4647930)"
FT /evidence="ECO:0000269|PubMed:11031111,
FT ECO:0000269|PubMed:11267671, ECO:0000269|PubMed:15489334"
FT /id="VAR_022642"
FT VARIANT 464
FT /note="P -> L (in dbSNP:rs4647932)"
FT /id="VAR_024316"
FT CONFLICT 374..380
FT /note="Missing (in Ref. 3; AAK15273)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 504 AA; 54537 MW; 56E35E57D5FC141B CRC64;
MTPSPLLLLL LPPLLLGAFP PAAAARGPPK MADKVVPRQV ARLGRTVRLQ CPVEGDPPPL
TMWTKDGRTI HSGWSRFRVL PQGLKVKQVE REDAGVYVCK ATNGFGSLSV NYTLVVLDDI
SPGKESLGPD SSSGGQEDPA SQQWARPRFT QPSKMRRRVI ARPVGSSVRL KCVASGHPRP
DITWMKDDQA LTRPEAAEPR KKKWTLSLKN LRPEDSGKYT CRVSNRAGAI NATYKVDVIQ
RTRSKPVLTG THPVNTTVDF GGTTSFQCKV RSDVKPVIQW LKRVEYGAEG RHNSTIDVGG
QKFVVLPTGD VWSRPDGSYL NKLLITRARQ DDAGMYICLG ANTMGYSFRS AFLTVLPDPK
PPGPPVASSS SATSLPWPVV IGIPAGAVFI LGTLLLWLCQ AQKKPCTPAP APPLPGHRPP
GTARDRSGDK DLPSLAALSA GPGVGLCEEH GSPAAPQHLL GPGPVAGPKL YPKLYTDIHT
HTHTHSHTHS HVEGKVHQHI HYQC
