FGRL1_MOUSE
ID FGRL1_MOUSE Reviewed; 529 AA.
AC Q91V87; Q920C2; Q920C3;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Fibroblast growth factor receptor-like 1;
DE Short=FGF receptor-like protein 1;
DE AltName: Full=Fibroblast growth factor receptor 5;
DE Short=FGFR-5;
DE Flags: Precursor;
GN Name=Fgfrl1; Synonyms=Fgfr5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE
RP SPECIFICITY, AND INTERACTION WITH FGF2.
RC STRAIN=BALB/cJ;
RX PubMed=11418238; DOI=10.1016/s0378-1119(01)00518-2;
RA Sleeman M., Fraser J., McDonald M., Yuan S., White D., Grandison P.,
RA Kumble K., Watson J.D., Murison J.G.;
RT "Identification of a new fibroblast growth factor receptor, FGFR5.";
RL Gene 271:171-182(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), AND DEVELOPMENTAL
RP STAGE.
RC TISSUE=Cartilage;
RX PubMed=11566361; DOI=10.1016/s0167-4781(01)00267-6;
RA Wiedemann M., Trueb B.;
RT "The mouse Fgfrl1 gene coding for a novel FGF receptor-like protein.";
RL Biochim. Biophys. Acta 1520:247-250(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=12813049; DOI=10.1074/jbc.m300281200;
RA Trueb B., Zhuang L., Taeschler S., Wiedemann M.;
RT "Characterization of FGFRL1, a novel fibroblast growth factor (FGF)
RT receptor preferentially expressed in skeletal tissues.";
RL J. Biol. Chem. 278:33857-33865(2003).
CC -!- FUNCTION: Has a negative effect on cell proliferation. {ECO:0000250,
CC ECO:0000269|PubMed:12813049}.
CC -!- SUBUNIT: Interacts with FGF2 with a low affinity.
CC {ECO:0000269|PubMed:11418238}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=FGFR5beta, FGFR5b;
CC IsoId=Q91V87-1; Sequence=Displayed;
CC Name=2; Synonyms=FGFR5gamma, FGFR5g;
CC IsoId=Q91V87-2; Sequence=VSP_013976;
CC -!- TISSUE SPECIFICITY: Highly expressed in the kidney, brain and lung.
CC Weakly expressed in the muscle, thymus, lymph node, stomach, intestine,
CC colon and liver. Expressed in fetal cartilaginous structures like the
CC nasal cartilage, the ribs and the sternum as well as in the
CC cartilaginous rudiments of developing bones such as the vertebrae and
CC the pelvic bone. High expression is found in the muscles of the tongue
CC and the diaphragm. {ECO:0000269|PubMed:11418238,
CC ECO:0000269|PubMed:12813049}.
CC -!- DEVELOPMENTAL STAGE: First detected at embryonic day 7 and became
CC clearly visible at day 11 and increased until day 17.
CC {ECO:0000269|PubMed:11566361}.
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DR EMBL; AF321300; AAL06295.1; -; mRNA.
DR EMBL; AF321301; AAL06296.1; -; mRNA.
DR EMBL; AF321302; AAL06297.1; -; Genomic_DNA.
DR EMBL; AJ293947; CAC82376.1; -; mRNA.
DR EMBL; AJ308490; CAC83768.1; -; Genomic_DNA.
DR EMBL; BC058745; AAH58745.1; -; mRNA.
DR CCDS; CCDS19518.1; -. [Q91V87-1]
DR CCDS; CCDS51592.1; -. [Q91V87-2]
DR RefSeq; NP_001157731.1; NM_001164259.1. [Q91V87-2]
DR RefSeq; NP_473412.1; NM_054071.2. [Q91V87-1]
DR RefSeq; XP_017176107.1; XM_017320618.1. [Q91V87-1]
DR AlphaFoldDB; Q91V87; -.
DR SMR; Q91V87; -.
DR BioGRID; 227959; 1.
DR STRING; 10090.ENSMUSP00000013633; -.
DR GlyGen; Q91V87; 4 sites.
DR iPTMnet; Q91V87; -.
DR PhosphoSitePlus; Q91V87; -.
DR PaxDb; Q91V87; -.
DR PeptideAtlas; Q91V87; -.
DR PRIDE; Q91V87; -.
DR ProteomicsDB; 271588; -. [Q91V87-1]
DR ProteomicsDB; 271589; -. [Q91V87-2]
DR Antibodypedia; 22198; 359 antibodies from 32 providers.
DR DNASU; 116701; -.
DR Ensembl; ENSMUST00000013633; ENSMUSP00000013633; ENSMUSG00000008090. [Q91V87-1]
DR Ensembl; ENSMUST00000112560; ENSMUSP00000108179; ENSMUSG00000008090. [Q91V87-2]
DR GeneID; 116701; -.
DR KEGG; mmu:116701; -.
DR UCSC; uc008ypa.2; mouse. [Q91V87-1]
DR UCSC; uc012eav.1; mouse. [Q91V87-2]
DR CTD; 53834; -.
DR MGI; MGI:2150920; Fgfrl1.
DR VEuPathDB; HostDB:ENSMUSG00000008090; -.
DR eggNOG; KOG0200; Eukaryota.
DR GeneTree; ENSGT00940000156736; -.
DR HOGENOM; CLU_038830_1_0_1; -.
DR InParanoid; Q91V87; -.
DR OMA; WAQPRFT; -.
DR OrthoDB; 612548at2759; -.
DR PhylomeDB; Q91V87; -.
DR Reactome; R-MMU-5658623; FGFRL1 modulation of FGFR1 signaling.
DR BioGRID-ORCS; 116701; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Fgfrl1; mouse.
DR PRO; PR:Q91V87; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q91V87; protein.
DR Bgee; ENSMUSG00000008090; Expressed in humerus cartilage element and 298 other tissues.
DR ExpressionAtlas; Q91V87; baseline and differential.
DR Genevisible; Q91V87; MM.
DR GO; GO:0044291; C:cell-cell contact zone; ISO:MGI.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0030133; C:transport vesicle; ISO:MGI.
DR GO; GO:0017134; F:fibroblast growth factor binding; IPI:MGI.
DR GO; GO:0005007; F:fibroblast growth factor receptor activity; IDA:UniProtKB.
DR GO; GO:0008201; F:heparin binding; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0001571; F:non-tyrosine kinase fibroblast growth factor receptor activity; ISA:MGI.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; ISA:MGI.
DR GO; GO:0098742; P:cell-cell adhesion via plasma-membrane adhesion molecules; ISO:MGI.
DR GO; GO:0060539; P:diaphragm development; IMP:MGI.
DR GO; GO:0003179; P:heart valve morphogenesis; IMP:MGI.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:MGI.
DR GO; GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IC:MGI.
DR GO; GO:0001501; P:skeletal system development; IMP:MGI.
DR GO; GO:0060412; P:ventricular septum morphogenesis; IMP:MGI.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR Pfam; PF07679; I-set; 2.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; SSF48726; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000250"
FT CHAIN 21..529
FT /note="Fibroblast growth factor receptor-like 1"
FT /id="PRO_0000021251"
FT TOPO_DOM 21..374
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 396..529
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 25..111
FT /note="Ig-like C2-type 1"
FT DOMAIN 143..233
FT /note="Ig-like C2-type 2"
FT DOMAIN 242..350
FT /note="Ig-like C2-type 3"
FT REGION 116..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 107
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 227
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 251
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 289
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 47..95
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 168..217
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 264..334
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 23..113
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11418238"
FT /id="VSP_013976"
SQ SEQUENCE 529 AA; 57013 MW; 6CE76A75BF2498DD CRC64;
MTRSPALLLL LLGALPSAEA ARGPPRMADK VVPRQVARLG RTVRLQCPVE GDPPPLTMWT
KDGRTIHSGW SRFRVLPQGL KVKEVEAEDA GVYVCKATNG FGSLSVNYTL IIMDDISPGK
ESPGPGGSSG GQEDPASQQW ARPRFTQPSK MRRRVIARPV GSSVRLKCVA SGHPRPDIMW
MKDDQTLTHL EASEHRKKKW TLSLKNLKPE DSGKYTCRVS NKAGAINATY KVDVIQRTRS
KPVLTGTHPV NTTVDFGGTT SFQCKVRSDV KPVIQWLKRV EYGSEGRHNS TIDVGGQKFV
VLPTGDVWSR PDGSYLNKLL ISRARQDDAG MYICLGANTM GYSFRSAFLT VLPDPKPPGP
PMASSSSSTS LPWPVVIGIP AGAVFILGTV LLWLCQTKKK PCAPASTLPV PGHRPPGTSR
ERSGDKDLPS LAVGICEEHG SAMAPQHILA SGSTAGPKLY PKLYTDVHTH THTHTCTHTL
SCGGQGSSTP ACPLSVLNTA NLQALCPEVG IWGPRQQVGR IENNGGRVS
