FGRL1_RAT
ID FGRL1_RAT Reviewed; 529 AA.
AC Q7TQM3; Q4V8P8;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Fibroblast growth factor receptor-like 1;
DE Short=FGF receptor-like protein 1;
DE Flags: Precursor;
GN Name=Fgfrl1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=12813049; DOI=10.1074/jbc.m300281200;
RA Trueb B., Zhuang L., Taeschler S., Wiedemann M.;
RT "Characterization of FGFRL1, a novel fibroblast growth factor (FGF)
RT receptor preferentially expressed in skeletal tissues.";
RL J. Biol. Chem. 278:33857-33865(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Has a negative effect on cell proliferation. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with FGF2 with a low affinity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250};
CC Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle,
CC secretory vesicle membrane {ECO:0000250}; Single-pass type I membrane
CC protein {ECO:0000250}. Note=Predominantly localized in the plasma
CC membrane but also detected in the Golgi and in secretory vesicles.
CC {ECO:0000250}.
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DR EMBL; AJ536020; CAD59914.1; -; mRNA.
DR EMBL; BC097261; AAH97261.1; -; mRNA.
DR RefSeq; NP_954545.1; NM_199114.1.
DR AlphaFoldDB; Q7TQM3; -.
DR SMR; Q7TQM3; -.
DR STRING; 10116.ENSRNOP00000000037; -.
DR GlyGen; Q7TQM3; 4 sites.
DR PaxDb; Q7TQM3; -.
DR PRIDE; Q7TQM3; -.
DR GeneID; 360903; -.
DR KEGG; rno:360903; -.
DR UCSC; RGD:735156; rat.
DR CTD; 53834; -.
DR RGD; 735156; Fgfrl1.
DR VEuPathDB; HostDB:ENSRNOG00000024207; -.
DR eggNOG; KOG0200; Eukaryota.
DR HOGENOM; CLU_038830_1_0_1; -.
DR InParanoid; Q7TQM3; -.
DR OMA; WAQPRFT; -.
DR OrthoDB; 612548at2759; -.
DR PhylomeDB; Q7TQM3; -.
DR Reactome; R-RNO-5658623; FGFRL1 modulation of FGFR1 signaling.
DR PRO; PR:Q7TQM3; -.
DR Proteomes; UP000002494; Chromosome 14.
DR Bgee; ENSRNOG00000024207; Expressed in pancreas and 19 other tissues.
DR Genevisible; Q7TQM3; RN.
DR GO; GO:0044291; C:cell-cell contact zone; ISO:RGD.
DR GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0030133; C:transport vesicle; ISO:RGD.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017134; F:fibroblast growth factor binding; ISO:RGD.
DR GO; GO:0005007; F:fibroblast growth factor receptor activity; ISO:RGD.
DR GO; GO:0008201; F:heparin binding; ISO:RGD.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0098742; P:cell-cell adhesion via plasma-membrane adhesion molecules; ISO:RGD.
DR GO; GO:0060539; P:diaphragm development; ISO:RGD.
DR GO; GO:0003179; P:heart valve morphogenesis; ISO:RGD.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0001501; P:skeletal system development; ISO:RGD.
DR GO; GO:0060412; P:ventricular septum morphogenesis; ISO:RGD.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR Pfam; PF07679; I-set; 2.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; SSF48726; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 2: Evidence at transcript level;
KW Cell membrane; Cytoplasmic vesicle; Disulfide bond; Glycoprotein;
KW Golgi apparatus; Immunoglobulin domain; Membrane; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000250"
FT CHAIN 21..529
FT /note="Fibroblast growth factor receptor-like 1"
FT /id="PRO_0000021252"
FT TOPO_DOM 21..374
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 396..529
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 25..111
FT /note="Ig-like C2-type 1"
FT DOMAIN 143..233
FT /note="Ig-like C2-type 2"
FT DOMAIN 242..350
FT /note="Ig-like C2-type 3"
FT REGION 117..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 107
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 227
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 251
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 289
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 47..95
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 168..217
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 264..334
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 529 AA; 57144 MW; 23D67B419335FFFC CRC64;
MTRSPALLLL LLGALPSAEA ARGPPRMADK VVPRQVARLG RTVRLQCPVE GDPPPLTMWT
KDGRTIHSGW SRFRVLPQGL KVKEVEAEDA GVYVCKATNG FGSLSVNYTL IIMDDISPGK
ENPGPGGSSG GQEDPVSQQW ARPRFTQPSK MRRRVIARPV GSSVRLKCVA SGHPRPDIMW
MKDDQTLTRL EASEHRKKKW TLSLKNLKPE DSGKYTCRVS NRAGAINATY KVDVIQRTRS
KPVLTGTHPV NTTVDFGGTT SFQCKVRSDV KPVIQWLKRV EYGSEGRHNS TIDVGGQKFV
VLPTGDVWSR PDGSYLNKLL ISRARQDDAG MYICLGANTM GYSFRSAFLT VLPDPKPPGP
PVAHSSSTTS LPWPVVIGIP AGAVFILGTV LLWLCQTKKK PCAPASTLPV PGHRPPGTSR
ERSGDKDLPS LAVGICEEHG STMAPQHILA PGSTAGPKLY PKLYTDVHTH THTHTCTHTL
SCGGQGSSAP ACPLSVLNTA NLQALCPEVG VWGPRQQVGR IENNGGRVS
