FH11_ARATH
ID FH11_ARATH Reviewed; 884 AA.
AC Q9MA60;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Formin-like protein 11;
DE Short=AtFH11;
DE Flags: Precursor;
GN Name=FH11; OrderedLocusNames=At3g05470; ORFNames=F22F7.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY ORGANIZATION, AND NOMENCLATURE.
RX PubMed=12417149; DOI=10.1016/s1360-1385(02)02341-5;
RA Deeks M.J., Hussey P.J., Davies B.;
RT "Formins: intermediates in signal-transduction cascades that affect
RT cytoskeletal reorganization.";
RL Trends Plant Sci. 7:492-498(2002).
RN [4]
RP GENE FAMILY ORGANIZATION, AND NOMENCLATURE.
RX PubMed=15256004; DOI=10.1186/1471-2164-5-44;
RA Cvrckova F., Novotny M., Pickova D., Zarsky V.;
RT "Formin homology 2 domains occur in multiple contexts in angiosperms.";
RL BMC Genomics 5:44-44(2004).
CC -!- FUNCTION: Might be involved in the organization and polarity of the
CC actin cytoskeleton. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the formin-like family. Class-I subfamily.
CC {ECO:0000305}.
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DR EMBL; AC009606; AAF64546.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74244.1; -; Genomic_DNA.
DR RefSeq; NP_187198.1; NM_111420.2.
DR AlphaFoldDB; Q9MA60; -.
DR SMR; Q9MA60; -.
DR STRING; 3702.AT3G05470.1; -.
DR iPTMnet; Q9MA60; -.
DR PaxDb; Q9MA60; -.
DR PRIDE; Q9MA60; -.
DR ProteomicsDB; 230092; -.
DR EnsemblPlants; AT3G05470.1; AT3G05470.1; AT3G05470.
DR GeneID; 819712; -.
DR Gramene; AT3G05470.1; AT3G05470.1; AT3G05470.
DR KEGG; ath:AT3G05470; -.
DR Araport; AT3G05470; -.
DR TAIR; locus:2079807; AT3G05470.
DR eggNOG; KOG1922; Eukaryota.
DR HOGENOM; CLU_007699_2_0_1; -.
DR InParanoid; Q9MA60; -.
DR OMA; GMLDNVC; -.
DR OrthoDB; 1204639at2759; -.
DR PhylomeDB; Q9MA60; -.
DR PRO; PR:Q9MA60; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9MA60; baseline and differential.
DR Genevisible; Q9MA60; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; ISS:TAIR.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0045010; P:actin nucleation; IEA:InterPro.
DR Gene3D; 1.20.58.2220; -; 1.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR027643; Formin-like_plant.
DR PANTHER; PTHR23213; PTHR23213; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM00498; FH2; 1.
DR PROSITE; PS51444; FH2; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..884
FT /note="Formin-like protein 11"
FT /id="PRO_0000308536"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 461..884
FT /note="FH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00774"
FT REGION 89..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..132
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..381
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..438
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 884 AA; 98535 MW; 56CD20CBAFA1F9A6 CRC64;
MVYFRQIFLM IIVVSLHCCK VRFFCIVANA KELDDWKVLT VENGERYRTH VGRYAGEEGG
EKIKLRVLEK FRALLDLIKP STSRRRNLAE SASFSPWPAP SPSPFPNGGP IESPAYPPAP
PRPIPPHLRR PLPQRTHPLE QPEIQRRKHE KGGTFKKILV PVVASTASAI GFVVCVVGVF
CLCARRKRKM NGKTLSFKRK KGKSQSSTRK VSVNPTLDFL YLNSLGVDLE RQNSVSVKEI
RETEKDLNGI NGGLLEEEVK RSIETEISHD WDNASSYSTK EIVSVHENDE EQTVNSVSVP
VVVINDSSDD DESFHSVGGG SQYSNPRLSN ASSASGSVNV GSSQRFSEHK LDIPECSRSD
FGISVSAPPP PPPPPPPLPQ FSNKRIHTLS SPETANLQTL SSQLCEKLCA SSSKTSFPIN
VPNSQPRPPP PPPPPQQLQV AGINKTPPPP LSLDFSERRP LGKDGAPLPK LKPLHWDKVR
ATPDRTMVWD KLRTSSFELD EEMIESLFGY TMQSSTKNEE GKSKTPSPGK HLLEPKRLQN
FTILLKALNA TADQICSALG KGEGLCLQQL EALVKMVPTK EEELKLRSYK GAVDELGSAE
KFLRALVGVP FAFQRAEAML YRETFEDEVV HLRNSFSMLE EACKELKSSR LFLKLLEAVL
KTGNRMNVGT IRGGAKAFKL DALLKLSDVK GTDGKTTLLH FVVQEISRSE GIRVSDSIMG
RIMNQRSNKN RTPEEKEEDY RRMGLDLVSG LNTELRNVKK TATIDLEGLV TSVSNLRDGL
GQLSCLASEK LKGDEENRAF VSSMSSFLRY GEKSLEELRE DEKRIMERVG EIAEYFHGDV
RGDEKNPLRI FVIVRDFLGM LDHVCRELRC VRVPNSPSPL APFR
