FH12_ORYSJ
ID FH12_ORYSJ Reviewed; 1669 AA.
AC Q7XWS7; Q0JEL7; Q0JEL8; Q7XWS8;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 3.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Formin-like protein 12;
DE AltName: Full=OsFH12;
GN Name=FH12;
GN OrderedLocusNames=Os04g0244900/Os04g0245000, LOC_Os04g17120/LOC_Os04g17130;
GN ORFNames=OSJNBa0091C12.4, OSJNBa0091C12.5;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447439; DOI=10.1038/nature01183;
RA Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y.,
RA Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q.,
RA Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T.,
RA Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R.,
RA Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G.,
RA Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C.,
RA Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J.,
RA Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J.,
RA Li J., Hong G., Xue Y., Han B.;
RT "Sequence and analysis of rice chromosome 4.";
RL Nature 420:316-320(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15256004; DOI=10.1186/1471-2164-5-44;
RA Cvrckova F., Novotny M., Pickova D., Zarsky V.;
RT "Formin homology 2 domains occur in multiple contexts in angiosperms.";
RL BMC Genomics 5:44-44(2004).
CC -!- SIMILARITY: Belongs to the formin-like family. Class-II subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAF14219.2; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes Os04g0244900 and Os04g0245000.; Evidence={ECO:0000305};
CC Sequence=BAF14220.2; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes Os04g0244900 and Os04g0245000.; Evidence={ECO:0000305};
CC Sequence=CAD39926.2; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes Os04g0244900 and Os04g0245000.; Evidence={ECO:0000305};
CC Sequence=CAD39927.2; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes Os04g0244900 and Os04g0245000.; Evidence={ECO:0000305};
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DR EMBL; AL662989; CAD39926.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AL662989; CAD39927.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008210; BAF14219.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008210; BAF14220.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q7XWS7; -.
DR SMR; Q7XWS7; -.
DR STRING; 4530.OS04T0245000-00; -.
DR PaxDb; Q7XWS7; -.
DR PRIDE; Q7XWS7; -.
DR eggNOG; KOG1922; Eukaryota.
DR HOGENOM; CLU_002558_1_0_1; -.
DR InParanoid; Q7XWS7; -.
DR Proteomes; UP000000763; Chromosome 4.
DR Proteomes; UP000059680; Chromosome 4.
DR GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.58.2220; -; 1.
DR Gene3D; 3.90.190.10; -; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR014020; Tensin_C2-dom.
DR Pfam; PF02181; FH2; 1.
DR Pfam; PF10409; PTEN_C2; 1.
DR SMART; SM00498; FH2; 1.
DR SMART; SM01326; PTEN_C2; 1.
DR SUPFAM; SSF49562; SSF49562; 1.
DR SUPFAM; SSF52799; SSF52799; 1.
DR PROSITE; PS51182; C2_TENSIN; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51181; PPASE_TENSIN; 1.
PE 3: Inferred from homology;
KW Hydrolase; Protein phosphatase; Reference proteome.
FT CHAIN 1..1669
FT /note="Formin-like protein 12"
FT /id="PRO_0000319012"
FT DOMAIN 5..193
FT /note="Phosphatase tensin-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00590"
FT DOMAIN 199..338
FT /note="C2 tensin-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00589"
FT DOMAIN 1247..1646
FT /note="FH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00774"
FT REGION 688..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1631..1669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1070
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1080..1227
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1631..1663
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 126
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00590"
SQ SEQUENCE 1669 AA; 182908 MW; 48525C102F9B375D CRC64;
MALLRRLFYR KPPDRLLEIA DRVYVFDCCF STETMEQFEY KNYLDNIVLQ LREQFVDSSL
MVFNFRDEGK SLVSGLFSLY GITVKDYPCQ YLGCPLLPLE MVLHFLRLSE RWLMLEGQQN
FLLMHCEKGG WPVLAFMLAG LLLYMKQYNG EERTLVMVYK QAPKELLQML TTLNPQPSHL
RYLQYICKMD DELEWPIQPI PFTLDCVILR EVPNFDGVGG CRPIVRVYGQ DFLTVDKRCN
VMLPPSKPRK HARRYKQQAD NISVKLNVGS CVQGDVVLEC LHIDDSLEDE RLMFRVMFNT
YFIQSHILPL NFENIDVSWD AEQRFTKKFK AEVLFSEFDG ESDASIEVAS DYDDEVEVGS
IDVFFEAVEI FSNLDSQEGQ RDAEILSITS TECSPRAELM KTAPFSHFDM EIGLGGSQKN
KIDGMVLSLE KSDEKCTSAE GDIIQNNITR VVRSSSANTT DGDRDTMNSS CYGGKVDGCI
VEKNNSNKEI LTDSNEDSGI ENVLVKEVII SETNSLKDIQ MIKEVIISEV TTSKPVIEVD
TIGTELSDVV HNSETITHAE ANNEEEVLVT LKQNEGDNLV EECIYYGNSI MIKPEKYRKK
EKSIIGSTIG VVPDSTEENS RVGLLLSVKP HLDSTGTYHD LNSPLQKIDL LNVSNTNCVE
EQTKGMEASI SNSYGQPSNL SSLNLQPQGS SFQANGDPTC ANTSTDANES TQLELKRKSF
LSLSTSSIFS PLSPRRNLLR STSTDLSFLS PLQTKSNQHS IPCSSGRDDF ASSYGPPPNI
PCTSLRTSKV SSLVHPSLRP LRTVSSLSQS SFEEYLDISP PSPTFHEKHQ QHFNLDPPSL
IPPWQLRLAK TKENEIYPCT LSFLPLSPSN KYAHHPPFPP PPPPPHVLCT QNNSRTQISE
YEQGRVEGPC PSSSYGQSIL NSHDVSLSLP QKDSSCIAIT NGPSSSNYVE EVPMETILNQ
PTLSIPLEAC KDELLHCKEN GGIPIPPPPP PLCDHAKKYT RIPLPPPPPE GSHGILATTS
TELIDAGPQL PPLSHLEWKR CPHHPPERPH YLPGEVGGAP SPPSPPPPQR ENTSVGIQGG
IPPLPPPLPP TLGDYGVAPP PPSIGAGAPP PPPPPGGITG VPPPPPIGGL GGHQAPPAPP
LPEGIGGVPP PPPVGGLGGP PAPPPPAGFR GGTPPPNAHG GVAPPPPPPR GHGGVGGPPT
PPGAPAPPMP PGVPGGPPPP PGGRGLPAPP GGRGVVGHGL TRSLGLNSAA TARRSTLKPL
HWVKVTRAMH GSLWAEIQKQ ADANSHSEFD VKELESLFAI APKTKGGSKS DGASKSLGSK
PDKVHLIDLR RANNTEIMLT KIKMPLPDMM SAALALDDSV LDADQLENLI KFCPTKEEME
LLKNYTGDKE TLGKCEQFFL ELMKVPRVES KFRIFAFKIQ FQSQIRDVRK NLLTVSSACE
ELRGSEKLKV IMEKILFLGN KLNQGTPRGQ ALGFRLDSLL KLTDTRANNS RMTLMHFLCK
GLADKSPHLL DFYEEFVNLE AASKLQLKAL AEEQQAVVKG LQKVEQELAA SESDGPVSEV
FRKTLKEFTD ASGADVRSLS ALYAEVGKSA DALAYYFGED PAKCPFEQVT STLLNFVGLF
RKAHEENIKQ IEADKKKAQK EAEKEANQDR TPVKSKDGLV DRSPRSPFK
