ID   FH18_ARATH              Reviewed;        1144 AA.
AC   Q9SK28; A0A2H1ZE40;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-JAN-2018, sequence version 3.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Formin-like protein 18;
DE            Short=AtFH18;
GN   Name=FH18; OrderedLocusNames=At2g25050; ORFNames=F27C12.3;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY ORGANIZATION, AND NOMENCLATURE.
RX   PubMed=12417149; DOI=10.1016/s1360-1385(02)02341-5;
RA   Deeks M.J., Hussey P.J., Davies B.;
RT   "Formins: intermediates in signal-transduction cascades that affect
RT   cytoskeletal reorganization.";
RL   Trends Plant Sci. 7:492-498(2002).
RN   [4]
RP   GENE FAMILY ORGANIZATION, AND NOMENCLATURE.
RX   PubMed=15256004; DOI=10.1186/1471-2164-5-44;
RA   Cvrckova F., Novotny M., Pickova D., Zarsky V.;
RT   "Formin homology 2 domains occur in multiple contexts in angiosperms.";
RL   BMC Genomics 5:44-44(2004).
CC   -!- SIMILARITY: Belongs to the formin-like family. Class-II subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD23008.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AEC07650.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC006585; AAD23008.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002685; AEC07650.2; ALT_SEQ; Genomic_DNA.
DR   PIR; F84643; F84643.
DR   RefSeq; NP_001318287.1; NM_001335971.1.
DR   AlphaFoldDB; Q9SK28; -.
DR   SMR; Q9SK28; -.
DR   STRING; 3702.AT2G25050.2; -.
DR   PaxDb; Q9SK28; -.
DR   PRIDE; Q9SK28; -.
DR   ProteomicsDB; 230509; -.
DR   GeneID; 817043; -.
DR   KEGG; ath:AT2G25050; -.
DR   Araport; AT2G25050; -.
DR   eggNOG; KOG1922; Eukaryota.
DR   InParanoid; Q9SK28; -.
DR   OrthoDB; 1204639at2759; -.
DR   PhylomeDB; Q9SK28; -.
DR   PRO; PR:Q9SK28; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9SK28; baseline and differential.
DR   GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.2220; -; 1.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR015425; FH2_Formin.
DR   InterPro; IPR042201; FH2_Formin_sf.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR014020; Tensin_C2-dom.
DR   Pfam; PF02181; FH2; 1.
DR   Pfam; PF10409; PTEN_C2; 1.
DR   SMART; SM00498; FH2; 1.
DR   SMART; SM01326; PTEN_C2; 1.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS51182; C2_TENSIN; 1.
DR   PROSITE; PS51444; FH2; 1.
DR   PROSITE; PS51181; PPASE_TENSIN; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Protein phosphatase; Reference proteome.
FT   CHAIN           1..1144
FT                   /note="Formin-like protein 18"
FT                   /id="PRO_0000308544"
FT   DOMAIN          17..193
FT                   /note="Phosphatase tensin-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00590"
FT   DOMAIN          199..338
FT                   /note="C2 tensin-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00589"
FT   DOMAIN          735..1135
FT                   /note="FH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00774"
FT   REGION          429..463
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          482..729
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        482..525
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        536..572
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        597..617
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        631..645
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        653..681
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        693..707
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        126
FT                   /note="Phosphocysteine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00590"
SQ   SEQUENCE   1144 AA;  127171 MW;  927C573AC391204B CRC64;
     MALFRKFFHR KPPEGLLEIS ERVYVFDCCL TTDMLEDEDY RVYVSRIMSQ LREQFPGASF
     MVFNFRDGDS RSRMESVLTE YDMTIMDYPR HYEGCPLLTM ETVHHFLKSA ESWLLLSQQN
     ILLSHCELGG WPTLAFMLAS LLLYRKQFSG EHRTLEMIYK QAPRELLQLM SPLNPLPSQL
     RFLQYISRRN VGSQWPPLDQ ALTLDCVNLR LIPDFDGEGG CRPIFRIYGQ DPFMASDRTS
     KVLFSMPKRS KAVRQYKQAD CELVKIDINC HILGDVVLEC ITLGSDLERE EMMFRVVFNT
     AFLRSNILTL NRGEIDVLWN TTDRFPKDFS AEVIFSEMGA GKKLASVDLP HMEEKDVLPM
     EAFAKVQEIF SEAEWLDPNS DVAVTVFNQI TAANILQESL DSGSPRSPDS RSLLESALEK
     VKEKTKLMIS ENIVSSPDTS SPEKEKDTMS SHKSYADPNS ILKKVDESRG LRVSVQRNVH
     SKIFSPRMVQ SPVTSPLPNR SPTQGSPASI SRFHSSPSSL GITSILHDHG SCKDEESTSS
     SPASPSISFL PTLHPLTSSQ PKKASPQCPQ SPTPVHSNGP PSAEAAVTSS PLPPLKPLRI
     LSRPPPPPPP PPISSLRSTP SPSSTSNSIA TQGPPPPPPP PPLQSHRSAL SSSPLPPPLP
     PKKLLATTNP PPPPPPPLHS NSRMGAPTSS LVLKSPPVPP PPAPAPLSRS HNGNIPPVPG
     PPLGLKGRGI LQNLKGQGQT RKANLKPYHW LKLTRAVQGS LWAEAQKSDE AATAPDFDIS
     ELEKLFSAVN LSSDSENNGG KSGRRARPKV EKVQLIELRR AYNCEIMLSK VKIPLPDLMS
     SVLALDESVI DVDQVDNLIK FCPTKEEAEL LKGFTGNKET LGRCEQFFLE LLKVPRVETK
     LRVFSFKIQF HSQVTDLRRG LNTIHSAANE VRGSAKLKRI MQTILSLGNA LNHGTARGSA
     IGFRLDSLLK LTDTRSRNSK MTLMHYLCKV LAEKLPELLN FPKDLVSLEA ATKIQLKYLA
     EEMQAISKGL EKVVQEFTAS ETDGQISKHF RMNLKEFLSV AEGEVRSLAS LYSTVGGSAD
     ALALYFGEDP ARVPFEQVVS TLQNFVRIFV RSHEENCKQV EFEKKRAQKE AENEKLKKGV
     YNEN