ID   FH18_ORYSJ              Reviewed;         906 AA.
AC   Q6MWG9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Formin-like protein 18;
DE   AltName: Full=OsFH18;
DE   Flags: Precursor;
GN   Name=FH18; OrderedLocusNames=Os04g0100300, LOC_Os04g01070;
GN   ORFNames=B1160F02.7;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12447439; DOI=10.1038/nature01183;
RA   Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y.,
RA   Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q.,
RA   Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T.,
RA   Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R.,
RA   Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G.,
RA   Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C.,
RA   Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J.,
RA   Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J.,
RA   Li J., Hong G., Xue Y., Han B.;
RT   "Sequence and analysis of rice chromosome 4.";
RL   Nature 420:316-320(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15256004; DOI=10.1186/1471-2164-5-44;
RA   Cvrckova F., Novotny M., Pickova D., Zarsky V.;
RT   "Formin homology 2 domains occur in multiple contexts in angiosperms.";
RL   BMC Genomics 5:44-44(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the formin-like family. Class-I subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAF13902.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; BX842604; CAE75976.1; -; Genomic_DNA.
DR   EMBL; AP008210; BAF13902.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP014960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_015635151.1; XM_015779665.1.
DR   AlphaFoldDB; Q6MWG9; -.
DR   SMR; Q6MWG9; -.
DR   STRING; 4530.OS04T0100300-00; -.
DR   PaxDb; Q6MWG9; -.
DR   PRIDE; Q6MWG9; -.
DR   GeneID; 4334883; -.
DR   KEGG; osa:4334883; -.
DR   eggNOG; KOG1922; Eukaryota.
DR   HOGENOM; CLU_007699_1_0_1; -.
DR   InParanoid; Q6MWG9; -.
DR   OrthoDB; 1204639at2759; -.
DR   Proteomes; UP000000763; Chromosome 4.
DR   Proteomes; UP000059680; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0045010; P:actin nucleation; IEA:InterPro.
DR   Gene3D; 1.20.58.2220; -; 1.
DR   InterPro; IPR015425; FH2_Formin.
DR   InterPro; IPR042201; FH2_Formin_sf.
DR   InterPro; IPR027643; Formin-like_plant.
DR   PANTHER; PTHR23213; PTHR23213; 2.
DR   Pfam; PF02181; FH2; 1.
DR   SMART; SM00498; FH2; 1.
DR   PROSITE; PS51444; FH2; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..906
FT                   /note="Formin-like protein 18"
FT                   /id="PRO_0000319007"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          411..866
FT                   /note="FH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00774"
FT   REGION          267..416
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          854..906
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..292
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        304..400
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        855..880
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        888..906
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   906 AA;  95753 MW;  F1320331430CC3FF CRC64;
     MSKLRWLIMA FLVCLLLLTP KDLEGLQLVG AIRNHLFWST SSPLHHLPDL LEEESVQVNE
     MELWGDDDGR RRMMGEEVRR QAGAGRMSEV KMGGDRPLVA VIKKEKHGAK KKKDDDSSGM
     VVVGLSAACV ALVTLVGICF CACRDSESSS SPYDLRDEKP LLSLNLSDGP SRKSCATTID
     VSRLGALTAE CEQHLHGGAG AGDHNTTNYN LRKPAGVGSM SMNKVSMQSQ AMRMSSHEIT
     TIAGAGRVEN KVSTIAPSAA AAAVASAGGG QVPAAPPPPA GPPPPAPPPL PPSHHHHHGH
     HPPPPHPLPP GAGAGAGTGA PPPPPAHPAA PAPPPPAPSP SAAGAGSGPP PPPPPAAPAA
     PRPPGPGPGP PPPPGAAGRG GGGPPPPALP GGPRARGPPP FKKSPGAAAA AAQADPNKAK
     LKPFFWDKVT ANPNQAMVWD QIKAGSFQFN EEMIESLFGA QSTEKKSTDA KKESGKEATQ
     FVRILDPKKA QNLAISLKAL SVSAEQVRAA VMEGHDLPPD LIQTLVRWSP TSDEELRLRL
     YAGEPAQLGP AEQFMRAIID VPYLYQRLDA LLFMAALPEE AAAVEQSFAT LEVACEELRG
     SRLFKKLLEA VLKTGNRMND GTFRGGAQAF KLDTLLKLAD VKGVDGKTTL LHFVVQEIIR
     SEGVRAARAA SGGGGGSSIS SISSSDDLIL LQSQSSIGSN SGRSSVDASS LEQEQDETER
     YRQLGLGVVS SLGDDLQNVR KAASFDADAL TITVASLGHR LVKANEFLST GMRSLEEDSG
     FQRRLASFVQ QSQEQVTRLL EDEKRLRSLV RATVDYFHGS TGKDEGLRLF VVVRDFLGIL
     DKVCREVKEQ AAANAKAKKQ QQPTPAPRSR QSSQSSFRDP RQQIQDRRAA ALSRNNSSSS
     SSDSDD