FH20_ARATH
ID FH20_ARATH Reviewed; 1649 AA.
AC Q9FLQ7; Q9FLQ8;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 3.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Formin-like protein 20;
DE Short=AtFH20;
GN Name=FH20; OrderedLocusNames=At5g07740/At5g07750;
GN ORFNames=MBK20.20/MBK20.21;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9628582; DOI=10.1093/dnares/5.1.41;
RA Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence
RT features of the regions of 1,456,315 bp covered by nineteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:41-54(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY ORGANIZATION, AND NOMENCLATURE.
RX PubMed=12417149; DOI=10.1016/s1360-1385(02)02341-5;
RA Deeks M.J., Hussey P.J., Davies B.;
RT "Formins: intermediates in signal-transduction cascades that affect
RT cytoskeletal reorganization.";
RL Trends Plant Sci. 7:492-498(2002).
RN [4]
RP GENE FAMILY ORGANIZATION, AND NOMENCLATURE.
RX PubMed=15256004; DOI=10.1186/1471-2164-5-44;
RA Cvrckova F., Novotny M., Pickova D., Zarsky V.;
RT "Formin homology 2 domains occur in multiple contexts in angiosperms.";
RL BMC Genomics 5:44-44(2004).
CC -!- SIMILARITY: Belongs to the formin-like family. Class-II subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB11453.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At5g07740 and At5g07750.; Evidence={ECO:0000305};
CC Sequence=BAB11454.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At5g07740 and At5g07750.; Evidence={ECO:0000305};
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DR EMBL; AB010070; BAB11453.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB010070; BAB11454.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED91199.1; -; Genomic_DNA.
DR RefSeq; NP_196391.2; NM_120856.4.
DR AlphaFoldDB; Q9FLQ7; -.
DR STRING; 3702.AT5G07740.1; -.
DR iPTMnet; Q9FLQ7; -.
DR PaxDb; Q9FLQ7; -.
DR PRIDE; Q9FLQ7; -.
DR EnsemblPlants; AT5G07740.1; AT5G07740.1; AT5G07740.
DR GeneID; 3770686; -.
DR Gramene; AT5G07740.1; AT5G07740.1; AT5G07740.
DR KEGG; ath:AT5G07740; -.
DR Araport; AT5G07740; -.
DR TAIR; locus:2160284; AT5G07740.
DR eggNOG; KOG1922; Eukaryota.
DR HOGENOM; CLU_002558_0_1_1; -.
DR InParanoid; Q9FLQ7; -.
DR OMA; HYITRRT; -.
DR PRO; PR:Q9FLQ7; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FLQ7; baseline and differential.
DR Genevisible; Q9FLQ7; AT.
DR GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.58.2220; -; 1.
DR Gene3D; 3.90.190.10; -; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR014020; Tensin_C2-dom.
DR Pfam; PF02181; FH2; 1.
DR Pfam; PF10409; PTEN_C2; 1.
DR SMART; SM00498; FH2; 1.
DR SMART; SM01326; PTEN_C2; 1.
DR SUPFAM; SSF49562; SSF49562; 1.
DR SUPFAM; SSF52799; SSF52799; 1.
DR PROSITE; PS51182; C2_TENSIN; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51181; PPASE_TENSIN; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Protein phosphatase; Reference proteome.
FT CHAIN 1..1649
FT /note="Formin-like protein 20"
FT /id="PRO_0000308546"
FT DOMAIN 1..194
FT /note="Phosphatase tensin-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00590"
FT DOMAIN 200..339
FT /note="C2 tensin-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00589"
FT DOMAIN 1237..1635
FT /note="FH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00774"
FT REGION 416..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..1245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..481
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..661
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..773
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..834
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..856
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..906
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 946..1216
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 127
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00590"
SQ SEQUENCE 1649 AA; 178147 MW; 6AF450A547B64A1A CRC64;
MALFRRFFYK KPPDRLLEIS ERVYVFDCCF SSDVMGEDEY KVYLGGIVAQ LQDHFPEASF
MVFNFREGEQ RSQISDVLSQ YDMTVMDYPR QYESCPLLPL EMIHHFLRSS ESWLSLEGQQ
NVLLMHCERG GWPVLAFMLS GLLLYRKQYH GEQKTLEMVH KQAPKELLHL LSPLNPQPSQ
LRYLQYISRR NLGSDWPPSD TPLLLDCLIL RDLPHFEGKK GCRPILRVYG QDPKARTNRS
SILLFSTLKT KKHTRLYQQE ECILVKLDIQ CRVQGDVVLE CIHLHDDLVS EEMVFRIMFH
TAFVRANILM LQRDEMDILW DVKDQFPKEF KAEVLFSGAD AVVPPITTST LSDDENDFDM
TSPEEFFEVE EIFSDVIDGP DHKRDSDSFV VVDTASDDSE GKEVWKGDVE PNAFLDCASD
DSNHKHDMHA ETSTDPVKDI TVDDVQYRSD GKADSNIDSV KDIGIDDGDE QRKRRTVEAK
ENDSSTVQTQ SKGDEESNDL ESMSQKTNTS LNKPISEKPQ ATLRKQVGAN AKPAAAGDSL
KPKSKQQETQ GPNVRMAKPN AVSRWIPSNK GSYKDSMHVA YPPTRINSAP ASITTSLKDG
KRATSPDGVI PKDAKTKYLR ASVSSPDMRS RAPICSSPDS SPKETPSSLP PASPHQAPPP
LPSLTSEAKT VLHSSQAVAS PPPPPPPPPL PTYSHYQTSQ LPPPPPPPPP FSSERPNSGT
VLPPPPPPPP PFSSERPNSG TVLPPPPPPP LPFSSERPNS GTVLPPPPSP PWKSVYASAL
AIPAICSTSQ APTSSPTPPP PPPAYYSVGQ KSSDLQTSQL PSPPPPPPPP PFASVRRNSE
TLLPPPPPPP PPPFASVRRN SETLLPPPPP PPPWKSLYAS TFETHEACST SSSPPPPPPP
PPFSPLNTTK ANDYILPPPP LPYTSIAPSP SVKILPLHGI SSAPSPPVKT APPPPPPPPF
SNAHSVLSPP PPSYGSPPPP PPPPPSYGSP PPPPPPPPSY GSPPPPPPPP PGYGSPPPPP
PPPPSYGSPP PPPPPPFSHV SSIPPPPPPP PMHGGAPPPP PPPPMHGGAP PPPPPPPMHG
GAPPPPPPPP MHGGAPPPPP PPMFGGAQPP PPPPMRGGAP PPPPPPMRGG APPPPPPPMR
GGAPPPPPPP MHGGAPPPPP PPMRGGAPPP PPPPGGRGPG APPPPPPPGG RAPGPPPPPG
PRPPGGGPPP PPMLGARGAA VDPRGAGRGR GLPRPGFGSA AQKKSSLKPL HWVKVTRALQ
GSLWDELQRH GESQTPSEFD VSEIETLFSA TVQKPADKSG SRRKSVGAKP EKVQLIDLRR
ANNTEIMLTK VKMPLPDMMA AVLAMDESVL DVDQIENLIK FCPTKEEMEL LKNYTGDKTT
LGKCEQYFLE LMKVPRVEAK LRVFSFKFQF GTQITEFKKS LNAVNSACEE VRSSQKLKEI
MKKILYLGNT LNQGTARGAA VGFKLDSLSK LSDTRAANSK MTLMHYLCKV LASKASVLLD
FPKDLESLES ASKIQLKSLA EEMQAIIKGL EKLNQELTAS ESDGPVSDVF RKTLGDFISV
AETEVATVSS LYSVVGRNAD ALAHYFGEDP NRCPFEQVTA TLLNFIRLFK KAHEENVKQA
ELEKKKALKE AEMEKAKGVN LTKKPVDDS
