ID   FH2_ORYSJ               Reviewed;         833 AA.
AC   Q7XUV2; B7EZN0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 2.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Formin-like protein 2;
DE   AltName: Full=OsFH2;
DE   Flags: Precursor;
GN   Name=FH2; OrderedLocusNames=Os04g0461800, LOC_Os04g38810;
GN   ORFNames=B1358B12.6, OSJNBa0072F16.14;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12447439; DOI=10.1038/nature01183;
RA   Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y.,
RA   Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q.,
RA   Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T.,
RA   Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R.,
RA   Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G.,
RA   Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C.,
RA   Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J.,
RA   Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J.,
RA   Li J., Hong G., Xue Y., Han B.;
RT   "Sequence and analysis of rice chromosome 4.";
RL   Nature 420:316-320(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15256004; DOI=10.1186/1471-2164-5-44;
RA   Cvrckova F., Novotny M., Pickova D., Zarsky V.;
RT   "Formin homology 2 domains occur in multiple contexts in angiosperms.";
RL   BMC Genomics 5:44-44(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the formin-like family. Class-I subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL606460; CAD40989.2; -; Genomic_DNA.
DR   EMBL; BX842605; CAE75997.1; -; Genomic_DNA.
DR   EMBL; AP008210; BAF14912.1; -; Genomic_DNA.
DR   EMBL; AP014960; BAS89557.1; -; Genomic_DNA.
DR   EMBL; AK106770; BAG97827.1; -; mRNA.
DR   RefSeq; XP_015634948.1; XM_015779462.1.
DR   AlphaFoldDB; Q7XUV2; -.
DR   SMR; Q7XUV2; -.
DR   STRING; 4530.OS04T0461800-01; -.
DR   PaxDb; Q7XUV2; -.
DR   PRIDE; Q7XUV2; -.
DR   EnsemblPlants; Os04t0461800-01; Os04t0461800-01; Os04g0461800.
DR   GeneID; 4336061; -.
DR   Gramene; Os04t0461800-01; Os04t0461800-01; Os04g0461800.
DR   KEGG; osa:4336061; -.
DR   eggNOG; KOG1922; Eukaryota.
DR   HOGENOM; CLU_007699_2_1_1; -.
DR   InParanoid; Q7XUV2; -.
DR   OMA; AWNPVPN; -.
DR   OrthoDB; 1204639at2759; -.
DR   Proteomes; UP000000763; Chromosome 4.
DR   Proteomes; UP000059680; Chromosome 4.
DR   Genevisible; Q7XUV2; OS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0045010; P:actin nucleation; IEA:InterPro.
DR   Gene3D; 1.20.58.2220; -; 1.
DR   InterPro; IPR015425; FH2_Formin.
DR   InterPro; IPR042201; FH2_Formin_sf.
DR   InterPro; IPR027643; Formin-like_plant.
DR   PANTHER; PTHR23213; PTHR23213; 1.
DR   Pfam; PF02181; FH2; 1.
DR   SMART; SM00498; FH2; 1.
DR   PROSITE; PS51444; FH2; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..833
FT                   /note="Formin-like protein 2"
FT                   /id="PRO_0000318996"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          438..833
FT                   /note="FH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00774"
FT   REGION          26..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          199..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          254..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          340..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..49
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        214..228
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        362..381
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        391..434
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   833 AA;  88899 MW;  714D415AF4904FEA CRC64;
     MSSSARGITL LCLLLIVSST VLHFSIGGGS NGEKRRDDGD GDGDDEKVRL LLGANALGER
     DRRHGHGHGG GVSSAPAPAP APARAHLPPP LLHKNARLPD PVPGRVGLGH RRGNATAAHR
     RRSEREGKKS TPLVVVAAGA ALSGAAAVLL VVLVVFLACR RFQRRAMPGA DQSGTNKVSF
     DPGPDVFYLD AVKPYVEADH GGGGGVVKTA PELAGPKEEP RCEEEDSGVA LSDDGADSVH
     SSCCFHSSHF SYSELRDTKP GSNGVSPSPS GRSRRRSSAP VTPSEKNKAA SPYSPQCPRT
     PSNRERSSRA HSPSSSVSDL TSVSTSVVKD HEVRRAVHSL MFPEAQSGGA GHVKEDEAES
     GNMRPPPPPP PPPPPPPPAV TQQQDVKTSC GPAVPPPPPP TPPPPPPLLA PKQQSSGGPI
     LPPAPAPPPL FRPWAPAVGK NGAPLPKLKP LHWDKVRAAP NRRMVWDRIR SSSFELDEKM
     IESLFGYNAR CSTKHEEVQS RSPSLGHHVL DTKRLQNFTI LMKAVSATAE QIFAALLHGN
     GLSAQQLEAL IKMAPAKDEA DKLSAYDGDV DGLVPAERLL KVVLTIPCAF ARVEAMLYRE
     TFADEVGHIR KSFEMLEEAC RELMSSKLFL KLLEAVLKTG NRMNVGTARG GAMAFKLDAL
     LKLADVKGTD GKTTLLHFVV QEMTRSRAAE AADIAAGLGA ELTNVRKTAT VDLDVLTTSV
     SGLSHGLSRI KELVGSDLSG DERNQCFVAF MAPFVAHAGE VIRELEDGER RVLAHVREIT
     EYYHGDVGKD EASPLRIFVI VRDFLGMLER VCKEVRGAKN CHGGNPALNL NNV