ID   FH3_ORYSJ               Reviewed;        1234 AA.
AC   Q7G6K7; Q0IZ88; Q7XH56; Q8W5K6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Formin-like protein 3;
DE   AltName: Full=OsFH3;
GN   Name=FH3; OrderedLocusNames=Os10g0119300, LOC_Os10g02980;
GN   ORFNames=OSJNAa0079B05.2, OSJNBa0079B05.10;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12791992; DOI=10.1126/science.1083523;
RA   Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S.,
RA   Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D.,
RA   Oates R., Palmer M., Pries G., Gibson J., Anderson H., Paradkar M.,
RA   Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F.,
RA   Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M.,
RA   Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R.,
RA   Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F.,
RA   Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D.,
RA   Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R.,
RA   Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K.,
RA   Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S.,
RA   Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S.,
RA   Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R.,
RA   Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M.,
RA   Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R.,
RA   Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E.,
RA   Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.;
RT   "In-depth view of structure, activity, and evolution of rice chromosome
RT   10.";
RL   Science 300:1566-1569(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 818-1234.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15256004; DOI=10.1186/1471-2164-5-44;
RA   Cvrckova F., Novotny M., Pickova D., Zarsky V.;
RT   "Formin homology 2 domains occur in multiple contexts in angiosperms.";
RL   BMC Genomics 5:44-44(2004).
CC   -!- SIMILARITY: Belongs to the formin-like family. Class-II subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL31655.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AAM08709.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AAP51898.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAF25977.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC079179; AAL31655.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AC116601; AAM08709.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; DP000086; AAP51898.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP008216; BAF25977.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP014966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK063350; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; Q7G6K7; -.
DR   SMR; Q7G6K7; -.
DR   STRING; 4530.OS10T0119300-01; -.
DR   PaxDb; Q7G6K7; -.
DR   PRIDE; Q7G6K7; -.
DR   eggNOG; ENOG502QQEE; Eukaryota.
DR   HOGENOM; CLU_028505_0_0_1; -.
DR   InParanoid; Q7G6K7; -.
DR   Proteomes; UP000000763; Chromosome 10.
DR   Proteomes; UP000059680; Chromosome 10.
DR   Genevisible; Q7G6K7; OS.
DR   GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.2220; -; 1.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR015425; FH2_Formin.
DR   InterPro; IPR042201; FH2_Formin_sf.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR014020; Tensin_C2-dom.
DR   Pfam; PF02181; FH2; 1.
DR   Pfam; PF10409; PTEN_C2; 1.
DR   SMART; SM00498; FH2; 1.
DR   SMART; SM01326; PTEN_C2; 1.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS51182; C2_TENSIN; 1.
DR   PROSITE; PS51444; FH2; 1.
DR   PROSITE; PS51181; PPASE_TENSIN; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Protein phosphatase; Reference proteome.
FT   CHAIN           1..1234
FT                   /note="Formin-like protein 3"
FT                   /id="PRO_0000319008"
FT   DOMAIN          1..208
FT                   /note="Phosphatase tensin-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00590"
FT   DOMAIN          214..352
FT                   /note="C2 tensin-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00589"
FT   DOMAIN          827..1226
FT                   /note="FH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00774"
FT   REGION          443..478
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          492..840
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        451..478
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        508..535
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        538..676
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        685..789
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        141
FT                   /note="Phosphocysteine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00590"
SQ   SEQUENCE   1234 AA;  134361 MW;  0AF059038030E105 CRC64;
     MRLDSFPASI SVPYEVRSGF QAQGGLPSPS GHTSLRVSVF DSCFCTEVLP HGMYPVYLTG
     ILTDLHEEHS QSSFLGINFR DGDKRSQLAD VLREYNVPVI DYPRHFEGCP VLPLSLIQHF
     LRVCEHWLST GNNQNIILLH CERGGWPSLA FMLSCLLIFK KLQSAEHKTL DLIYREAPKG
     FLQLFSALNP MPSQLRYLQY VARRNISPEW PPMERALSFD CLILRAIPSF DSDNGCRPLV
     RIFGRNIIGK NASTSNMIFS MPKKKTLRHY RQEDCDVIKI DIQCPVQGDV VLECVHLDLD
     PEKEVMMFRI MFNTAFIRSN VLMLNSDDID IVWGSKDQYP RNFRAEMLFC ELGGISPARP
     PTATLNGDMK GGLPIEAFSA VQELFNGVDW MESSDNAAFW LLKEFSANSL QEKFQKLILS
     DMEELSKFQA KVGLQIPLMS PLDSDEEKYS VASDSVSSSE HEKVQPGGNS SDSENINHDL
     TTEDTASMGN VLVNTPSVLP PTTPPPCGSL SILSTDENQL PPEVQHESPS DRKLPSPSPT
     AAAPPPPPPP PPPPSGNKPA FSPPPPPPPP PPPPLPQSNY ASSQPPPPPP PPPLPNCLVP
     SPPPPPPPPP ILPNRSVPPP PPPPPPLPNH SVLPPPPPPP PPPSLPNRLV PPPPAPGIGN
     KFPAPPPPPP PPRSSSRTPT GAATSSKGPP PPPPPPLPPA NRTNGPGVPS APPPPPPPPP
     ANRSNGPSAP APPLPPPLPA AANKRNPPAP PPPPLMTGKK APAPPPPPPQ APKPPGTVPP
     PPPLHGASGR PHPPSSKGLN APAPPPLLGR GREATGSAKG RGIGLAQQSN PPKKASLKPL
     HWVKVTRAMQ GSLWEDAQKQ GNQARAPDID LSELESLFST AVATNASEKG GTKRGSAISK
     PEIVHLVDMR RANNCEIMLT KIKMPLPDMI NAILALDTSV LDNDQVENLI KFCPTKEEIE
     MLKNYNGNKE MLGKCEQFFL ELMKVPRVES KLRVFAFRIT FSTQVEELRT NLTTINDATK
     EVKESLKLRQ IMQTILTLGN ALNQGTARGS AVGFRLDSLL KLSDTRARNN KMTLMHYLCK
     LLSEKLPELL DFDKDLIHLE AASKIQLKLL AEEMQAINKG LEKVEQELAA SVNDGAISVG
     FREALKSFLD AAEAEVRSLI SLYSEVGRNA DSLAQYFGED PARCPFEQVT SILVIFVNMF
     KKSRDENART AELEKKKLEK DKEKATLSAK KVLE