ID   FH4_ORYSJ               Reviewed;         849 AA.
AC   Q8H8K7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Formin-like protein 4;
DE   AltName: Full=OsFH4;
DE   Flags: Precursor;
GN   Name=FH4; OrderedLocusNames=Os10g0347800, LOC_Os10g20710;
GN   ORFNames=OSJNBb0078C13.8;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12791992; DOI=10.1126/science.1083523;
RA   Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S.,
RA   Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D.,
RA   Oates R., Palmer M., Pries G., Gibson J., Anderson H., Paradkar M.,
RA   Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F.,
RA   Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M.,
RA   Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R.,
RA   Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F.,
RA   Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D.,
RA   Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R.,
RA   Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K.,
RA   Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S.,
RA   Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S.,
RA   Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R.,
RA   Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M.,
RA   Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R.,
RA   Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E.,
RA   Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.;
RT   "In-depth view of structure, activity, and evolution of rice chromosome
RT   10.";
RL   Science 300:1566-1569(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15256004; DOI=10.1186/1471-2164-5-44;
RA   Cvrckova F., Novotny M., Pickova D., Zarsky V.;
RT   "Formin homology 2 domains occur in multiple contexts in angiosperms.";
RL   BMC Genomics 5:44-44(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the formin-like family. Class-I subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AC091666; AAN05367.1; -; Genomic_DNA.
DR   EMBL; DP000086; AAP53183.1; -; Genomic_DNA.
DR   EMBL; AP008216; BAF26316.1; -; Genomic_DNA.
DR   EMBL; AP014966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q8H8K7; -.
DR   SMR; Q8H8K7; -.
DR   STRING; 4530.OS10T0347800-00; -.
DR   PaxDb; Q8H8K7; -.
DR   PRIDE; Q8H8K7; -.
DR   eggNOG; KOG1922; Eukaryota.
DR   InParanoid; Q8H8K7; -.
DR   Proteomes; UP000000763; Chromosome 10.
DR   Proteomes; UP000059680; Chromosome 10.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0045010; P:actin nucleation; IEA:InterPro.
DR   Gene3D; 1.20.58.2220; -; 1.
DR   InterPro; IPR015425; FH2_Formin.
DR   InterPro; IPR042201; FH2_Formin_sf.
DR   InterPro; IPR027643; Formin-like_plant.
DR   PANTHER; PTHR23213; PTHR23213; 1.
DR   Pfam; PF02181; FH2; 1.
DR   SMART; SM00498; FH2; 1.
DR   PROSITE; PS51444; FH2; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..849
FT                   /note="Formin-like protein 4"
FT                   /id="PRO_0000318997"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          406..823
FT                   /note="FH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00774"
FT   REGION          36..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          185..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..57
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        247..274
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        278..301
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        322..361
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   849 AA;  90281 MW;  411C80AA6230004A CRC64;
     MPPTLALLLF LALSAVAAVG GAGDVRRVLH EPLFPIEWTP PPSTASPSPP SPDFSSDPST
     PATPVDNGGP ALLPPPPPNT VAADVSSSRS GPDPRARGGG GGGTPKAAIV VASAAAAAVL
     ALLAFAAAFL LTGRLARHPA AAAAQAHKPP GHAHAGAGSV AGAHADVAGC STAVSPYRKV
     RPERARRGMC RDVDTVPSPE LRPLPPLRRG ASALTQGSSD EDAAYYTPGQ RSAGSGGGGG
     GEGGGTWSEA SASSPRTTTA SRRSLPSLTS DFFPTTPAAA PVPAPAAAAP PPAPPAPRSR
     RTPPRTRFSA GSGAEMNKQM ASPPSNPPPA PPPPPPPPSR FNNTTPKPPP PPPPPEPPTG
     PVSARRLLRP LPAEGPSIVI PRAPAMAVTK DNDATAATMS VRTRGEAAGD EPRPKLKPLH
     WDKVRTSSDR DMVWDRLKLD EDMIEVLFMN NSTAVAPRMD NPKKVGMPQF KQEERVLDPK
     KAQNIAILLR ALNVTLEEVT DALLDGNAEC LGAELLETLV KMAPTKEEEL KLRDFTGDLS
     KLGSAERFLK AVLDIPFAFK RVDVMLYRAN FENEVNYLRK SFQTLEAACD DLKGSRLFLK
     LLEAVLRTGN RMNVGTNRGE AKAFKLDTLL KLADVKGADG KTTLLHFVVQ EIVRSEDAKS
     EKAPENHITN IAKVEQLRRQ GLKVVSGLST ELGNVKRAAT MDFDVLHGYV SKLEAGLGKI
     KSVLQLEKQC SQGVNFFATM REFLKEAEQE IEQVRHDEKA ALGRVKEITE YFHGNAVKEE
     AHPLRIFMVV RDFLSMLDHV CREVSQQDRT FVGSARSFRI SAANALPILN MQGQKGGRES
     SSDGDSPSM