FH5_ORYSJ
ID FH5_ORYSJ Reviewed; 1627 AA.
AC Q84ZL0; Q0D4Y8;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Formin-like protein 5;
DE AltName: Full=OsFH5;
GN Name=FH5; OrderedLocusNames=Os07g0596300, LOC_Os07g40510/LOC_Os07g40520;
GN ORFNames=P0453E05.107;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 874-1627 (ISOFORM 1).
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15256004; DOI=10.1186/1471-2164-5-44;
RA Cvrckova F., Novotny M., Pickova D., Zarsky V.;
RT "Formin homology 2 domains occur in multiple contexts in angiosperms.";
RL BMC Genomics 5:44-44(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q84ZL0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q84ZL0-2; Sequence=VSP_031340;
CC -!- SIMILARITY: Belongs to the formin-like family. Class-II subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAF22085.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP004275; BAC55695.1; -; Genomic_DNA.
DR EMBL; AP008213; BAF22085.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK120222; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015646968.1; XM_015791482.1. [Q84ZL0-1]
DR AlphaFoldDB; Q84ZL0; -.
DR SMR; Q84ZL0; -.
DR STRING; 4530.OS07T0596300-01; -.
DR PaxDb; Q84ZL0; -.
DR PRIDE; Q84ZL0; -.
DR EnsemblPlants; Os07t0596300-02; Os07t0596300-02; Os07g0596300. [Q84ZL0-1]
DR GeneID; 4343793; -.
DR Gramene; Os07t0596300-02; Os07t0596300-02; Os07g0596300. [Q84ZL0-1]
DR KEGG; osa:4343793; -.
DR eggNOG; KOG1922; Eukaryota.
DR HOGENOM; CLU_028505_3_0_1; -.
DR InParanoid; Q84ZL0; -.
DR Proteomes; UP000000763; Chromosome 7.
DR Proteomes; UP000059680; Chromosome 7.
DR ExpressionAtlas; Q84ZL0; baseline and differential.
DR Genevisible; Q84ZL0; OS.
DR GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.58.2220; -; 1.
DR Gene3D; 3.90.190.10; -; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR014020; Tensin_C2-dom.
DR Pfam; PF02181; FH2; 1.
DR Pfam; PF10409; PTEN_C2; 1.
DR SMART; SM00498; FH2; 1.
DR SMART; SM01326; PTEN_C2; 1.
DR SUPFAM; SSF49562; SSF49562; 1.
DR SUPFAM; SSF52799; SSF52799; 1.
DR PROSITE; PS51182; C2_TENSIN; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51181; PPASE_TENSIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Hydrolase; Protein phosphatase; Reference proteome.
FT CHAIN 1..1627
FT /note="Formin-like protein 5"
FT /id="PRO_0000319009"
FT DOMAIN 5..194
FT /note="Phosphatase tensin-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00590"
FT DOMAIN 200..337
FT /note="C2 tensin-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00589"
FT DOMAIN 1188..1588
FT /note="FH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00774"
FT REGION 369..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..1181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1241..1261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1571..1627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..413
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..736
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..837
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..888
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..1170
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1571..1594
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1595..1614
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 127
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00590"
FT VAR_SEQ 1598..1627
FT /note="DSKPSNPSRQVKQTPDTKTRAASRRGKDVG -> VLILDLYLWQLQPTSYIH
FT RIYKIQNLLTGL (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_031340"
FT CONFLICT 935
FT /note="P -> R (in Ref. 4; AK120222)"
FT /evidence="ECO:0000305"
FT CONFLICT 1260
FT /note="Missing (in Ref. 4; AK120222)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1627 AA; 176353 MW; 0158A7C3E49490AA CRC64;
MALFRKFFLK KTPDRLLEIS ERVYVFDCCF STDSMGEDEY RDYLSGIVAQ LQDYFPDASF
MVSNFWSGDK RSRISDILSE YDMTVMDYPQ QYEGCPLLQL EMIHHFLKSC ENWLSVEGQH
NMLLMHCERG GWPVLAFMLA GLLLYRKTYT GEQKTLEMVY KQARRDFIQQ FFPLNPQSSH
MRYLHYITRQ GSGPEKPPIS RPLILDSIVL HVVPRFDAEG GCRPYLRVHG QDSSSSNKSA
KVLYEMPKTK KHLQRYGQAE VPVKVGAFCR VQGDVVLECI HIGDNLDHEE IMFRVMFNTA
FIQSNILGLN RDDIDVSWNS NNQFPRDFRA EVVFSDPGSF KPAAATVEEV DDDGDETDVA
SVDTGEEFYE AEEDWHDARR DPETQSTDGR TSIGDAELDG GVSREDSGSL EKHRADEDVK
IVISQNLGCM SDRPVSAPAE ILGNPGGLQQ ACENEEMPKL SNRSDQDDNA VQDIQVVAAS
VDSEGHKFGS ICQKEDMKGV IAQTLVTAID PSCSDEVQCQ PDESAKILKY PNLDYTGFSS
PRTLSSVDED TRLGTIPNVA LQNADVKIIT ESTVIVDNEL VIYEEKTIVD NGNLTQEVKN
VVNEESTTPK LDRSVIESVD SQDNKNHKME VAKAADTTDS KMEQTKLKSG LEDAISLKKT
TVQGSIVVLP ATEIATKIKT KREESGGRRD VGISLPQSKI EARAKSPRIS SDRRQIPDKV
VPSKKMPVDH APEAVLLEEK LGNSDQSQEQ PKAVKPKTVR RWISPNKESE TTSVHRPSHP
PSRYDSSPAA LAIHSMHTNN KFNVGKDAPL VSSGAQAVPK IQAAPPPPPP PPPPYASSSS
LSMHMGSATK QQPPPPPPPP PLPPPPPPPA SSGLSSIPPP PPPPPLMSFG AQTRTFVPPP
PPPPPPPRSG VGGNTPPAPP PPPLRSTVPA ISPPPPPPPP PLKPSSGAPC PPPPPPPPPP
PPPSAPSSRA FSSAPPPPPP PPLLRSVPPP PPPPPISHSN APPPPPLPAA RFNAPPPPPP
PPTTHFNAPP PPPPPPITRS GAPPSPPPPP SPPPPPPPPG ARPGPPPPPP PPGARPGPPP
PPPPPGGRPS APPLPPPGGR ASAPPPPPPP STRLGAPPPP PPPGAGGRAP PPPPAPGGRL
GGPPPPPPPG GRAPPPPRGP GAPPPPGGNP SSLIGRGRGV VRASGSGFGA AAARKSTLKP
LHWIKVTRAL QGSLWEELQR NDDSQSVSEF DLSELESLFP AAVPKPNDSS KSDSRRKSLG
SKPEKVHLIE LRRANNTEIM LTKVKMPLPD LVSAALALDQ STLDVDQVEN LIKFCPTKEE
MELLKNYTGD KENLGKCEQF FLELMKVPRM ESKLRVFSFK IQFGSQVADL RKSLNTIDSS
CDEIRSSLKL KEIMKKILLL GNTLNQGTAR GAAVGFRLDS LLKLTDTRAT NNKMTLMHYL
CKVLAAKSSQ LLDFYMDLVS LEATSKIQLK MLAEEMQAVS KGLEKVQLEY NASESDGPVS
EIFREKLKEF TDNAGADVQS LSSLFSEVGK KADALIKYFG EDPVRCPFEQ VISTLLTFVT
MFRKAHEENR KQAELDKKRA EKEAEAEKSK AQLASKNDSK PSNPSRQVKQ TPDTKTRAAS
RRGKDVG
