FH6_ORYSJ
ID FH6_ORYSJ Reviewed; 1364 AA.
AC Q6ZCX3; A3BRH2; Q0J6R0;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Formin-like protein 6;
DE AltName: Full=OsFH6;
GN Name=FH6; OrderedLocusNames=Os08g0280200, LOC_Os08g17820;
GN ORFNames=OJ1003_E05.5-1, OsJ_025644, P0026A08.31-1;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [5]
RP PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15256004; DOI=10.1186/1471-2164-5-44;
RA Cvrckova F., Novotny M., Pickova D., Zarsky V.;
RT "Formin homology 2 domains occur in multiple contexts in angiosperms.";
RL BMC Genomics 5:44-44(2004).
CC -!- SIMILARITY: Belongs to the formin-like family. Class-II subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC99403.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAC99532.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAF23355.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP003936; BAC99403.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP004556; BAC99532.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008214; BAF23355.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM000145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK069036; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK100610; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015648506.1; XM_015793020.1.
DR RefSeq; XP_015648507.1; XM_015793021.1.
DR RefSeq; XP_015648508.1; XM_015793022.1.
DR RefSeq; XP_015648509.1; XM_015793023.1.
DR RefSeq; XP_015648510.1; XM_015793024.1.
DR AlphaFoldDB; Q6ZCX3; -.
DR SMR; Q6ZCX3; -.
DR STRING; 4530.OS08T0280200-02; -.
DR PaxDb; Q6ZCX3; -.
DR PRIDE; Q6ZCX3; -.
DR GeneID; 9269435; -.
DR KEGG; osa:9269435; -.
DR eggNOG; KOG1922; Eukaryota.
DR HOGENOM; CLU_291097_0_0_1; -.
DR InParanoid; Q6ZCX3; -.
DR OrthoDB; 1204639at2759; -.
DR Proteomes; UP000000763; Chromosome 8.
DR Proteomes; UP000007752; Chromosome 8.
DR Proteomes; UP000059680; Chromosome 8.
DR Genevisible; Q6ZCX3; OS.
DR GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.58.2220; -; 1.
DR Gene3D; 3.90.190.10; -; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR014020; Tensin_C2-dom.
DR Pfam; PF02181; FH2; 1.
DR Pfam; PF10409; PTEN_C2; 1.
DR SMART; SM00498; FH2; 1.
DR SMART; SM01326; PTEN_C2; 1.
DR SUPFAM; SSF49562; SSF49562; 1.
DR SUPFAM; SSF52799; SSF52799; 1.
DR PROSITE; PS51182; C2_TENSIN; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51181; PPASE_TENSIN; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Protein phosphatase; Reference proteome.
FT CHAIN 1..1364
FT /note="Formin-like protein 6"
FT /id="PRO_0000319010"
FT DOMAIN 9..193
FT /note="Phosphatase tensin-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00590"
FT DOMAIN 199..338
FT /note="C2 tensin-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00589"
FT DOMAIN 922..1322
FT /note="FH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00774"
FT REGION 614..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 976..999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1317..1364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..631
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..695
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..747
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..814
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..840
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 849..898
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 915..929
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..999
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1317..1347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1348..1364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 126
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00590"
FT CONFLICT 917
FT /note="S -> P (in Ref. 5; AK100610)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1364 AA; 149846 MW; 1A1A0F0CC5B69B3F CRC64;
MALFRKFFYR KPPDGLLEIT ERVYVFDSCF TTDVFNDDKY QDYIGDIVAQ LQCHFADASF
MVFNFREGES QSLLANILSS YEMVVMDYPR QYEGCPLVTI EMIHHFLRSG ESWLSLSQQN
VLIMHCERGG WAVLAFMLAG LLLYRKQYIG EQRTLEMIYR QAPRELIQLL SPLNPIPSQI
RYLHYISRRN VSAVWPPGDR ALTLDCVILR NIPGFNGEGG CRPIFRIYGK DPLLATSNTP
KVLFSTPKRS KYVRLYKKVD CELIKIDIHC HIQGDVVLEC ISLDADQQRE EMIFRVMFNT
AFIRSNILML NRDEIDILWD AKDRFPKEFR AEVLFSEMDS VNQLDSMEVG GIGEKEGLPV
EAFAKVQEMF SNVDWLDPTA DAAALLFQQL TSSENIQLRK GLLSPNKKDF HLSSISPTKK
QSDNVEDKLS NAELSTIYVH KQENNDVQGL IPQKQATIPD EKSGSSVIHE KMISLVHEEI
TQVVDINTGC LSSLDMTVPS TMNSSRPVLI DQNSKLDDQF GSLQSSSPTM IMSQQFPVSR
SSSVLSSDFS PRLLSACPRF HSAPSALGIT ALLEDHAAFG DTKNSVKVSS AVVKIPSKQS
SQQHPITVTP VVTKCTPSPP PLLPPLAPVV PVPSDDQMIS QEKDMSQQAQ KHPDLSSFPS
LSPTQQKQST SKLCQTILPT NHQLSSSNIT KEPLQISPAP TPPPLPTPST SSSSSCHCLP
PDSMLSTTTA LFRPPAPPPP PLQSPSTPRC SPVRTLASPP PPPAPTSSPV RMSGPPPPPP
PPAPNSCPSR PAPPPPPPPP LASTSSPPRP AAPSPCQLHT STSSPARPVP PPPPTLSTIR
SSAPTPPLLP GATSAPSPPP PPPPCSSSNQ LSAPPPPPPS FSKNNGSIAP PPAPPGGNAK
LPGMRGRGPA PPSGPMSRSL QSGQAASRRS NLKPLHWVKV TRAMQGSLWE ESQKTDEASK
PPVFDMSELE HLFSAVLPSS DGKRSDKSGS RASGSKPEKI HLIDLRRANN CGIMLTKVKM
PLPDLMSAIL TLDDTILDAD QVENLIKFTP TKEEAELLKG YKGDKQVLGE CEQFFMELMK
LPRVDSKLRV FLFKIQFPSQ VSDLKRSLNI VNSSAEEIRG SAKLKRIMQT ILSLGNALNQ
GTARGSAVGF RLDSLLKLSD TRARNNKMTL MHYLSKVLSE KLPELLDFPK DLASLELAAK
VQLKSLAEEM QAINKGLEKV EQELTTSEND GPVSEIFRKT LKDFLSGAEA EVRSLTSLYS
NVGRNADALA LYFGEDPARC PFEQVVITLQ NFVRLFVRSH DENCKQLDLE KKKALKEAEA
EKTKKEPENA QKTKEPGNDK AKHNNSIKEL DISLQSPAQT ASAK
