FH8_ORYSJ
ID FH8_ORYSJ Reviewed; 892 AA.
AC Q10Q99; A0A0P0VUD6;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Formin-like protein 8;
DE AltName: Full=OsFH8;
DE Flags: Precursor;
GN Name=FH8; OrderedLocusNames=Os03g0204100, LOC_Os03g10680;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16109971; DOI=10.1101/gr.3869505;
RG The rice chromosome 3 sequencing consortium;
RA Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA Jin W., Lee H.R., Jiang J., Jackson S.;
RT "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT and diverged grass species.";
RL Genome Res. 15:1284-1291(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15256004; DOI=10.1186/1471-2164-5-44;
RA Cvrckova F., Novotny M., Pickova D., Zarsky V.;
RT "Formin homology 2 domains occur in multiple contexts in angiosperms.";
RL BMC Genomics 5:44-44(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the formin-like family. Class-I subfamily.
CC {ECO:0000305}.
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DR EMBL; DP000009; ABF94532.1; -; Genomic_DNA.
DR EMBL; AP008209; BAF11223.1; -; Genomic_DNA.
DR EMBL; AP014959; BAS82845.1; -; Genomic_DNA.
DR EMBL; AK121042; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015628713.1; XM_015773227.1.
DR AlphaFoldDB; Q10Q99; -.
DR SMR; Q10Q99; -.
DR STRING; 4530.OS03T0204100-01; -.
DR PaxDb; Q10Q99; -.
DR PRIDE; Q10Q99; -.
DR EnsemblPlants; Os03t0204100-01; Os03t0204100-01; Os03g0204100.
DR GeneID; 4331986; -.
DR Gramene; Os03t0204100-01; Os03t0204100-01; Os03g0204100.
DR KEGG; osa:4331986; -.
DR eggNOG; KOG1922; Eukaryota.
DR HOGENOM; CLU_007699_0_0_1; -.
DR InParanoid; Q10Q99; -.
DR OMA; RMPPSNF; -.
DR OrthoDB; 1204639at2759; -.
DR Proteomes; UP000000763; Chromosome 3.
DR Proteomes; UP000059680; Chromosome 3.
DR Genevisible; Q10Q99; OS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0045010; P:actin nucleation; IEA:InterPro.
DR Gene3D; 1.20.58.2220; -; 1.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR027643; Formin-like_plant.
DR PANTHER; PTHR23213; PTHR23213; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM00498; FH2; 1.
DR PROSITE; PS51444; FH2; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..892
FT /note="Formin-like protein 8"
FT /id="PRO_0000318998"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 446..867
FT /note="FH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00774"
FT REGION 43..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..91
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..317
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..397
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 408
FT /note="P -> L (in Ref. 5; AK121042)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 892 AA; 95344 MW; 1E1E882EC9A960B3 CRC64;
MPPAIARFVA IAAVLLCGHV AVAAESGGVG GGSARRVLHQ PLFPIEWTPP PSPPPPPAPD
FTSDPSTPPA PDAPSGDFFP PAPPTTTTPT SPGTTPSPTT VAADVSKTPS GSGSGHHGGG
PTKATIVAAG AGAAAAVALL GFACAFLITG RARRRGDSQK LLGPDRAGAH RSAATSAADF
LYVGTVEPTT PARHHGPTTA DLVGSPYRKL RSERARRGVS RDEDADHPSP ELRPLPPLRR
AATLGSSDED GYYTPRQLSG GSGGGGAAEA WSSASASSPP TTTTASRRSL PSMTSDFFPP
VAAIAAPPAP PPARSRRTPP RTRFSTGSTP DTKQVTSPSP RPVQPSNAPP PPPPPPPPPP
PPPPPKLNTA PKPPPPPPPP PSVPSNNNLP KPAEPPAVPT SRRRLLKPLP PEGPRIAMPM
PITAATTVDN NGSTSMREGD NAAADDGGSG EPRPKLKPLH WDKVRATSDR AMVWDQLKSS
SFQLDEDMIE ALFMNNSTPA APPREVGRKA AGVPSFRQEE RVLDPKKAQN IAILLRALNV
TREEVSDALL DGNAECLGSE LLETLVKMAP TKEEELKLRD YSGDLSKLGS AERFLKAVLD
IPFAFKRVDA MLYRANFETE INYLRNSFET LEAACEDLRG SRLFLKLLEA VLRTGNRMNV
GTNRGEAKAF KLDTLLKLAD VKGTDGKTTL LHFVVQEIIR SEDAKSEKES AMISSSKDDR
KHGLKVVSGL SSELGNVKKA ATMDFDVLHG YVNKLETGLE KIKSVLQLEK KCTQGQRFFM
SMQDFLKEAE REIERVRGEE RRALGRVKDI TEYFHGDTAK EEAHPLRIFM VVRDFLSTLD
QVCREVGRMQ QDRTVIGGSA RSFRISATSS LPVLSLYGQR RENNSDDDSS SS
