FH9_ARATH
ID FH9_ARATH Reviewed; 782 AA.
AC Q8GX37; Q9LK78;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Formin-like protein 9;
DE Short=AtFH9;
DE Flags: Precursor;
GN Name=FH9; OrderedLocusNames=At5g48360; ORFNames=K23F3_8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP GENE FAMILY ORGANIZATION, AND NOMENCLATURE.
RX PubMed=12417149; DOI=10.1016/s1360-1385(02)02341-5;
RA Deeks M.J., Hussey P.J., Davies B.;
RT "Formins: intermediates in signal-transduction cascades that affect
RT cytoskeletal reorganization.";
RL Trends Plant Sci. 7:492-498(2002).
RN [5]
RP GENE FAMILY ORGANIZATION, AND NOMENCLATURE.
RX PubMed=15256004; DOI=10.1186/1471-2164-5-44;
RA Cvrckova F., Novotny M., Pickova D., Zarsky V.;
RT "Formin homology 2 domains occur in multiple contexts in angiosperms.";
RL BMC Genomics 5:44-44(2004).
CC -!- FUNCTION: Might be involved in the organization and polarity of the
CC actin cytoskeleton. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the formin-like family. Class-I subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA98193.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP000372; BAA98193.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED95658.1; -; Genomic_DNA.
DR EMBL; AK118458; BAC43066.1; -; mRNA.
DR RefSeq; NP_199647.2; NM_124211.3.
DR AlphaFoldDB; Q8GX37; -.
DR SMR; Q8GX37; -.
DR BioGRID; 20135; 6.
DR IntAct; Q8GX37; 6.
DR STRING; 3702.AT5G48360.1; -.
DR iPTMnet; Q8GX37; -.
DR PaxDb; Q8GX37; -.
DR PRIDE; Q8GX37; -.
DR ProteomicsDB; 230419; -.
DR EnsemblPlants; AT5G48360.1; AT5G48360.1; AT5G48360.
DR GeneID; 834889; -.
DR Gramene; AT5G48360.1; AT5G48360.1; AT5G48360.
DR KEGG; ath:AT5G48360; -.
DR Araport; AT5G48360; -.
DR TAIR; locus:2156248; AT5G48360.
DR eggNOG; KOG1922; Eukaryota.
DR HOGENOM; CLU_007699_0_0_1; -.
DR InParanoid; Q8GX37; -.
DR OMA; IHSERNE; -.
DR OrthoDB; 1204639at2759; -.
DR PhylomeDB; Q8GX37; -.
DR PRO; PR:Q8GX37; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8GX37; baseline and differential.
DR Genevisible; Q8GX37; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; ISS:TAIR.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0045010; P:actin nucleation; IEA:InterPro.
DR Gene3D; 1.20.58.2220; -; 1.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR027643; Formin-like_plant.
DR PANTHER; PTHR23213; PTHR23213; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM00498; FH2; 1.
DR PROSITE; PS51444; FH2; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..782
FT /note="Formin-like protein 9"
FT /id="PRO_0000308534"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 406..782
FT /note="FH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00774"
FT REGION 191..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 232
FT /note="A -> V (in Ref. 3; BAC43066)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 782 AA; 87120 MW; D48056454D4B1B03 CRC64;
MQNFWFAIFF FLLTCAPPSP LSYASTVTLS RRLLYDYESP LPLPLSPISP PFFPLESSPP
SPPPPLPPTP PTTFAVFPTF PANISALVLP RSSKPHHTSP TLLLPALSAV LVIATVIGLA
LFLYGRHRGQ TRHLKNSHCS SSNTSSYGDE QSHITTNFNM AATTSPSEVF YLNTEESDHI
RTGGTFFLKQ DSPEIRPLPP LPPRSFHHNN YETEVNEEDE EEEEDVFFSP MASLPGSANS
SPSHSCSSSC SGWVSPARSF SITMSPPNPR YSDATNLQSP SPERLRVRKN YNGNGSSSLR
MFSFWNQNMG FGFPRISSAS TSPDRGFIRT PLSSLYSSVS TSPDGLFRKF LDSSPPIWND
FSRNVKSVLL SHTASSRRDF VINIGESSSQ QSKVPALPPP TRPPPLVPPS QPFVVQNDVK
KQSFSDQPPK QLHWERLRSS SSKLSKEMVE TMFIANSSNP RDLPIQNQVL DPRKAQNIAT
LLQLLNLSTK DVCQALLDGD CDVLGAELLE CLSRLAPSKE EERKLKSFSD GSEIGPAERF
LKELLHVPFV FKRVDALLFV ANFHSEIKRL RKSFSVVQVA CEELRNSRMF SILLEAILKT
GNMMSVRTNR CGDADAFKLD TLLKLVDVKG LDGRSSLLHF VVQEMMKSEG SVRALEGIRN
LNTELSNVKK SADIEYGVLR SNVSRICQGL KNIEALLLLS EESGSYGDQW LKFKERMTRF
LKTAAEEIVK IKIRESSTLS ALEEVTEQFH GDASKEGHTM RIFMIVRDFL SVLDQVCKEM
GD
