FHA1_ARATH
ID FHA1_ARATH Reviewed; 251 AA.
AC Q9SFV6;
DT 29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=FHA domain-containing protein FHA1 {ECO:0000305};
DE AltName: Full=Protein FORKHEAD-ASSOCIATED DOMAIN 1 {ECO:0000303|Ref.3};
DE Short=AtFHA1 {ECO:0000303|Ref.3};
GN Name=FHA1 {ECO:0000303|Ref.3};
GN OrderedLocusNames=At3g07260 {ECO:0000312|Araport:AT3G07260};
GN ORFNames=T1B9.7 {ECO:0000312|EMBL:AAF20220.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX DOI=10.1016/S0168-9452(03)00290-5;
RA Ahn J.-W., Kim M., Bang J.-W., Pai H.-S.;
RT "Molecular characteristics and differential expression of two nuclear
RT factors containing the FHA domain in Arabidopsis.";
RL Plant Sci. 165:1023-1032(2003).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=23192389; DOI=10.1007/s00425-012-1815-7;
RA Ahn E.R., Cho H.K., Pai H.S.;
RT "The forkhead-associated domain 2 (FHA2) in Arabidopsis plays a role in
RT plant fertility by regulating stamen development.";
RL Planta 237:1015-1023(2013).
CC -!- FUNCTION: May play a role in the control of plant organ development (By
CC similarity). Does not show transactivation activity in yeast
CC (PubMed:23192389). {ECO:0000250|UniProtKB:Q9SFV2,
CC ECO:0000269|PubMed:23192389}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23192389,
CC ECO:0000269|Ref.3}. Note=Detected at discrete loci in the nucleus.
CC {ECO:0000269|PubMed:23192389}.
CC -!- TISSUE SPECIFICITY: Expressed in roots and vascular tissues near the
CC shoot apex in young seedlings. {ECO:0000269|Ref.3}.
CC -!- INDUCTION: By auxin, cytokinin, gibberellin, abscisic acid (ABA),
CC brassinosteroid and hypoxia. {ECO:0000269|Ref.3}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions. {ECO:0000269|PubMed:23192389}.
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DR EMBL; AC012395; AAF20220.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74519.1; -; Genomic_DNA.
DR RefSeq; NP_187382.1; NM_111606.2.
DR AlphaFoldDB; Q9SFV6; -.
DR SMR; Q9SFV6; -.
DR IntAct; Q9SFV6; 28.
DR STRING; 3702.AT3G07260.1; -.
DR PaxDb; Q9SFV6; -.
DR PRIDE; Q9SFV6; -.
DR ProteomicsDB; 230420; -.
DR EnsemblPlants; AT3G07260.1; AT3G07260.1; AT3G07260.
DR GeneID; 819914; -.
DR Gramene; AT3G07260.1; AT3G07260.1; AT3G07260.
DR KEGG; ath:AT3G07260; -.
DR Araport; AT3G07260; -.
DR TAIR; locus:2098540; AT3G07260.
DR eggNOG; KOG2294; Eukaryota.
DR HOGENOM; CLU_068161_0_0_1; -.
DR InParanoid; Q9SFV6; -.
DR OMA; MQAYSIM; -.
DR OrthoDB; 1093684at2759; -.
DR PhylomeDB; Q9SFV6; -.
DR PRO; PR:Q9SFV6; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SFV6; baseline and differential.
DR Genevisible; Q9SFV6; AT.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0060962; P:regulation of ribosomal protein gene transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd00060; FHA; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR045178; Fhl1/FHA1.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR21712; PTHR21712; 1.
DR Pfam; PF00498; FHA; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF49879; SSF49879; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Nucleus; Reference proteome.
FT CHAIN 1..251
FT /note="FHA domain-containing protein FHA1"
FT /id="PRO_0000433003"
FT DOMAIN 32..89
FT /note="FHA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT REGION 163..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 251 AA; 27980 MW; 836862BA78A78CB2 CRC64;
MATAVGSGSD VEVGFAKLQG EDFEYYMQSY SIILGRNSKK STVDVDLSSL GGGMNISRNH
ARIFYDFTRR RFSLEVLGKN GCFVEGVLHL PGNPNVKLDS QDLLQIGDKE FYFLLPVWSI
LGGPLGPRHH VLGKATVVPY HNYHSGPGSG SGKNGVRSRE LYEYDDEDDD EEEDIRGSGK
KTWRDGHEGV YASGEKKREG RSKADREADD QQFLQLMHGS GWSVTDIKGV WKRMASQSSK
KIPITRRLGY P
