ID   FHA1_TOBAC              Reviewed;         209 AA.
AC   Q945P0;
DT   29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Transcriptional activator FHA1 {ECO:0000303|PubMed:12149245};
DE   AltName: Full=Protein FORKHEAD-ASSOCIATED DOMAIN 1 {ECO:0000303|PubMed:12149245};
DE            Short=NtFHA1 {ECO:0000303|PubMed:12149245};
GN   Name=FHA1 {ECO:0000303|PubMed:12149245};
OS   Nicotiana tabacum (Common tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, DEVELOPMENTAL STAGE, AND MUTAGENESIS OF ARG-34 AND SER-55.
RC   STRAIN=cv. Xanti;
RX   PubMed=12149245; DOI=10.1074/jbc.m201559200;
RA   Kim M., Ahn J.W., Song K., Paek K.H., Pai H.S.;
RT   "Forkhead-associated domains of the tobacco NtFHA1 transcription activator
RT   and the yeast Fhl1 forkhead transcription factor are functionally
RT   conserved.";
RL   J. Biol. Chem. 277:38781-38790(2002).
RN   [2]
RP   FUNCTION.
RX   PubMed=23192389; DOI=10.1007/s00425-012-1815-7;
RA   Ahn E.R., Cho H.K., Pai H.S.;
RT   "The forkhead-associated domain 2 (FHA2) in Arabidopsis plays a role in
RT   plant fertility by regulating stamen development.";
RL   Planta 237:1015-1023(2013).
CC   -!- FUNCTION: Transcription regulator that may be involved in the control
CC       of the pre-rRNA processing machinery. Can rescue the phenotypes of slow
CC       growth and defective rRNA processing in the yeast fhl1 null mutant
CC       (PubMed:12149245). Shows transactivation activity in yeast
CC       (PubMed:23192389). {ECO:0000269|PubMed:12149245,
CC       ECO:0000269|PubMed:23192389}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12149245}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, stems, leaves, young flower
CC       buds and open flowers. {ECO:0000269|PubMed:12149245}.
CC   -!- DEVELOPMENTAL STAGE: Down-regulated in germinating seeds between 3 and
CC       5 days after germination. Down-regulated in flowers from 5 days after
CC       pollination. {ECO:0000269|PubMed:12149245}.
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DR   EMBL; AF411856; AAL05884.1; -; mRNA.
DR   AlphaFoldDB; Q945P0; -.
DR   SMR; Q945P0; -.
DR   STRING; 4097.Q945P0; -.
DR   Proteomes; UP000084051; Unplaced.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0060962; P:regulation of ribosomal protein gene transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:UniProtKB.
DR   CDD; cd00060; FHA; 1.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR045178; Fhl1/FHA1.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   PANTHER; PTHR21712; PTHR21712; 1.
DR   Pfam; PF00498; FHA; 1.
DR   SMART; SM00240; FHA; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
DR   PROSITE; PS50006; FHA_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..209
FT                   /note="Transcriptional activator FHA1"
FT                   /id="PRO_0000433005"
FT   DOMAIN          30..87
FT                   /note="FHA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT   REGION          157..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         34
FT                   /note="R->A: Loss of function."
FT                   /evidence="ECO:0000269|PubMed:12149245"
FT   MUTAGEN         55
FT                   /note="S->A: Loss of function."
FT                   /evidence="ECO:0000269|PubMed:12149245"
SQ   SEQUENCE   209 AA;  22601 MW;  E3440C7327070176 CRC64;
     MGSSSGSDVE AGFAKLQGED FEYYMQTYSI ILGRNSKKST VDVDLSSLGG GMNISRHHAR
     IFYDFQRRRF NLEVLGKNGC FVEGVLHLPG NPPIKLDSQD LLQIGDKEFY FLLPVRSILG
     GGPPIGPKQN VNYPVAAHYG GIGKKGGLFR GREREYYDEE EYDDDDDDDD GTGGKKMRRC
     DGAEGGGGYG GYGSCGSSGK ASISGQLGQ