FHAB_BORPE
ID FHAB_BORPE Reviewed; 3590 AA.
AC P12255; Q45364;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2003, sequence version 4.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Filamentous hemagglutinin;
GN Name=fhaB; OrderedLocusNames=BP1879;
OS Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Bordetella.
OX NCBI_TaxID=257313;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RX PubMed=2388559; DOI=10.1111/j.1365-2958.1990.tb00649.x;
RA Relman D.A., Domenighini M., Tuomanen E., Rappuoli R., Falkow S.;
RT "Genetic characterization of Bordetella pertussis filamentous
RT haemagglutinin: a protein processed from an unusually large precursor.";
RL Mol. Microbiol. 4:787-800(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251;
RX PubMed=12910271; DOI=10.1038/ng1227;
RA Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA Barrell B.G., Maskell D.J.;
RT "Comparative analysis of the genome sequences of Bordetella pertussis,
RT Bordetella parapertussis and Bordetella bronchiseptica.";
RL Nat. Genet. 35:32-40(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-3261.
RC STRAIN=BP338;
RX PubMed=2539596; DOI=10.1073/pnas.86.8.2637;
RA Relman D.A., Domenighini M., Tuomanen E., Rappuoli R., Falkow S.;
RT "Filamentous hemagglutinin of Bordetella pertussis: nucleotide sequence and
RT crucial role in adherence.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:2637-2641(1989).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-1087.
RC STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251;
RX PubMed=1696934; DOI=10.1128/iai.58.9.2895-2905.1990;
RA Delisse-Gathoye A.M., Locht C., Jacob F., Raaschou-Nielsen M., Heron I.,
RA Ruelle J.L., De Wilde M., Cabezon T.;
RT "Cloning, partial sequence, expression and antigenic analysis of the
RT filamentous hemagglutinin gene of Bordetella pertussis.";
RL Infect. Immun. 58:2895-2905(1990).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35.
RX PubMed=1791761; DOI=10.1111/j.1365-2958.1991.tb02094.x;
RA Scarlato V., Prugnola A., Arico B., Rappuoli R.;
RT "The bvg-dependent promoters show similar behaviour in different Bordetella
RT species and share sequence homologies.";
RL Mol. Microbiol. 5:2493-2498(1991).
CC -!- FUNCTION: Evidence for a role in host-cell binding and infection.
CC -!- SUBCELLULAR LOCATION: Cell surface. Note=Secreted to the cell surface
CC by FhaC, its two partner secretion pathway (TPS) partner.
CC {ECO:0000305}.
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DR EMBL; M60351; AAA22974.1; -; Genomic_DNA.
DR EMBL; BX640416; CAE42162.1; -; Genomic_DNA.
DR EMBL; X53405; CAA37481.1; -; Genomic_DNA.
DR PIR; S21010; S21010.
DR RefSeq; NP_880571.1; NC_002929.2.
DR RefSeq; WP_010930610.1; NZ_CP039022.1.
DR PDB; 1RWR; X-ray; 1.72 A; A=72-372.
DR PDBsum; 1RWR; -.
DR SMR; P12255; -.
DR IntAct; P12255; 1.
DR MINT; P12255; -.
DR STRING; 257313.BP1879; -.
DR PRIDE; P12255; -.
DR ABCD; P12255; 3 sequenced antibodies.
DR KEGG; bpe:BP1879; -.
DR PATRIC; fig|257313.5.peg.2018; -.
DR eggNOG; COG3064; Bacteria.
DR eggNOG; COG3210; Bacteria.
DR eggNOG; COG4223; Bacteria.
DR HOGENOM; CLU_000227_1_0_4; -.
DR OMA; DKQVIDV; -.
DR EvolutionaryTrace; P12255; -.
DR Proteomes; UP000002676; Chromosome.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0003824; F:catalytic activity; IEA:UniProt.
DR GO; GO:0043170; P:macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR Gene3D; 2.160.20.10; -; 1.
DR InterPro; IPR024973; ESPR.
DR InterPro; IPR008619; Filamentous_hemagglutn_rpt.
DR InterPro; IPR008638; Filamn_hemagglutn_N.
DR InterPro; IPR025157; Hemagglutinin_rpt.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR Pfam; PF13018; ESPR; 1.
DR Pfam; PF05594; Fil_haemagg; 9.
DR Pfam; PF13332; Fil_haemagg_2; 1.
DR Pfam; PF05860; Haemagg_act; 1.
DR SMART; SM00912; Haemagg_act; 1.
DR SUPFAM; SSF51126; SSF51126; 1.
DR TIGRFAMs; TIGR01901; adhes_NPXG; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Hemagglutinin; Reference proteome.
FT CHAIN 1..3590
FT /note="Filamentous hemagglutinin"
FT /id="PRO_0000087234"
FT REGION 3256..3309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3417..3498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3282..3299
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3422..3436
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3461..3475
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 280
FT /note="G -> R (in Ref. 4; CAA37481)"
FT /evidence="ECO:0000305"
FT CONFLICT 284
FT /note="G -> A (in Ref. 4; CAA37481)"
FT /evidence="ECO:0000305"
FT CONFLICT 507..508
FT /note="KQ -> NE (in Ref. 1; AAA22974, 3 and 4; CAA37481)"
FT /evidence="ECO:0000305"
FT CONFLICT 516
FT /note="E -> V (in Ref. 4; CAA37481)"
FT /evidence="ECO:0000305"
FT CONFLICT 614
FT /note="A -> G (in Ref. 4; CAA37481)"
FT /evidence="ECO:0000305"
FT CONFLICT 1454
FT /note="A -> P (in Ref. 1; AAA22974 and 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 3574..3590
FT /note="VEDIGGKNYRVFYETNK -> SRISAARTTGSSMKPTNR (in Ref. 1;
FT AAA22974)"
FT /evidence="ECO:0000305"
FT STRAND 81..83
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 91..93
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 101..109
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 116..121
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 126..128
FT /evidence="ECO:0007829|PDB:1RWR"
FT TURN 129..131
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 132..134
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 145..151
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 157..168
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 170..175
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 180..196
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 198..203
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 206..211
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 215..218
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 229..240
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 254..265
FT /evidence="ECO:0007829|PDB:1RWR"
FT TURN 266..269
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 270..273
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 285..290
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 299..305
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 311..314
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 318..330
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 332..350
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 352..359
FT /evidence="ECO:0007829|PDB:1RWR"
FT STRAND 363..367
FT /evidence="ECO:0007829|PDB:1RWR"
SQ SEQUENCE 3590 AA; 367522 MW; C00BD8E22C9DB41D CRC64;
MNTNLYRLVF SHVRGMLVPV SEHCTVGNTF CGRTRGQARS GARATSLSVA PNALAWALML
ACTGLPLVTH AQGLVPQGQT QVLQGGNKVP VVNIADPNSG GVSHNKFQQF NVANPGVVFN
NGLTDGVSRI GGALTKNPNL TRQASAILAE VTDTSPSRLA GTLEVYGKGA DLIIANPNGI
SVNGLSTLNA SNLTLTTGRP SVNGGRIGLD VQQGTVTIER GGVNATGLGY FDVVARLVKL
QGAVSSKQGK PLADIAVVAG ANRYDHATRR ATPIAAGARG AAAGAYAIDG TAAGAMYGKH
ITLVSSDSGL GVRQLGSLSS PSAITVSSQG EIALGDATVQ RGPLSLKGAG VVSAGKLASG
GGAVNVAGGG AVKIASASSV GNLAVQGGGK VQATLLNAGG TLLVSGRQAV QLGAASSRQA
LSVNAGGALK ADKLSATRRV DVDGKQAVAL GSASSNALSV RAGGALKAGK LSATGRLDVD
GKQAVTLGSV ASDGALSVSA GGNLRAKQLV SSAQLEVRGQ REVALDDASS ARGMTVVAAG
ALAARNLQSK GAIGVQGGEA VSVANANSDA ELRVRGRGQV DLHDLSAARG ADISGEGRVN
IGRARSDSDV KVSAHGALSI DSMTALGAIG VQAGGSVSAK DMRSRGAVTV SGGGAVNLGD
VQSDGQVRAT SAGAMTVRDV AAAADLALQA GDALQAGFLK SAGAMTVNGR DAVRLDGAHA
GGQLRVSSDG QAALGSLAAK GELTVSAARA ATVAELKSLD NISVTGGERV SVQSVNSASR
VAISAHGALD VGKVSAKSGI GLEGWGAVGA DSLGSDGAIS VSGRDAVRVD QARSLADISL
GAEGGATLGA VEAAGSIDVR GGSTVAANSL HANRDVRVSG KDAVRVTAAT SGGGLHVSSG
RQLDLGAVQA RGALALDGGA GVALQSAKAS GTLHVQGGEH LDLGTLAAVG AVDVNGTGDV
RVAKLVSDAG ADLQAGRSMT LGIVDTTGDL QARAQQKLEL GSVKSDGGLQ AAAGGALSLA
AAEVAGALEL SGQGVTVDRA SASRARIDST GSVGIGALKA GAVEAASPRR ARRALRQDFF
TPGSVVVRAQ GNVTVGRGDP HQGVLAQGDI IMDAKGGTLL LRNDALTENG TVTISADSAV
LEHSTIESKI SQSVLAAKGD KGKPAVSVKV AKKLFLNGTL RAVNDNNETM SGRQIDVVDG
RPQITDAVTG EARKDESVVS DAALVADGGP IVVEAGELVS HAGGIGNGRN KENGASVTVR
TTGNLVNKGY ISAGKQGVLE VGGALTNEFL VGSDGTQRIE AQRIENRGTF QSQAPAGTAG
ALVVKAAEAI VHDGVMATKG EMQIAGKGGG SPTVTAGAKA TTSANKLSVD VASWDNAGSL
DIKKGGAQVT VAGRYAEHGE VSIQGDYTVS ADAIALAAQV TQRGGAANLT SRHDTRFSNK
IRLMGPLQVN AGGAVSNTGN LKVREGVTVT AASFDNETGA EVMAKSATLT TSGAARNAGK
MQVKEAATIV AASVSNPGTF TAGKDITVTS RGGFDNEGKM ESNKDIVIKT EQFSNGRVLD
AKHDLTVTAS GQADNRGSLK AGHDFTVQAQ RIDNSGTMAA GHDATLKAPH LRNTGQVVAG
HDIHIINSAK LENTGRVDAR NDIALDVADF TNTGSLYAEH DATLTLAQGT QRDLVVDQDH
ILPVAEGTLR VKAKSLTTEI ETGNPGSLIA EVQENIDNKQ AIVVGKDLTL SSAHGNVANE
ANALLWAAGE LTVKAQNITN KRAALIEAGG NARLTAAVAL LNKLGRIRAG EDMHLDAPRI
ENTAKLSGEV QRKGVQDVGG GEHGRWSGIG YVNYWLRAGN GKKAGTIAAP WYGGDLTAEQ
SLIEVGKDLY LNAGARKDEH RHLLNEGVIQ AGGHGHIGGD VDNRSVVRTV SAMEYFKTPL
PVSLTALDNR AGLSPATWNF QSTYELLDYL LDQNRYEYIW GLYPTYTEWS VNTLKNLDLG
YQAKPAPTAP PMPKAPELDL RGHTLESAEG RKIFGEYKKL QGEYEKAKMA VQAVEAYGEA
TRRVHDQLGQ RYGKALGGMD AETKEVDGII QEFAADLRTV YAKQADQATI DAETDKVAQR
YKSQIDAVRL QAIQPGRVTL AKALSAALGA DWRALGHSQL MQRWKDFKAG KRGAEIAFYP
KEQTVLAAGA GLTLSNGAIH NGENAAQNRG RPEGLKIGAH SATSVSGSFD ALRDVGLEKR
LDIDDALAAV LVNPHIFTRI GAAQTSLADG AAGPALARQA RQAPETDGMV DARGLGSADA
LASLASLDAA QGLEVSGRRN AQVADAGLAG PSAVAAPAVG AADVGVEPVT GDQVDQPVVA
VGLEQPVATV RVAPPAVALP RPLFETRIKF IDQSKFYGSR YFFEQIGYKP DRAARVAGDN
YFDTTLVREQ VRRALGGYES RLPVRGVALV AKLMDSAGTV GKALGLKVGV APTAQQLKQA
DRDFVWYVDT VIDGQKVLAP RLYLTEATRQ GITDQYAGGG ALIASGGDVT VNTDGHDVSS
VNGLIQGRSV KVDAGKGKVV VADSKGAGGG IEADDEVDVS GRDIGIEGGK LRGKDVRLKA
DTVKVATSMR YDDKGRLAAR GDGALDAQGG QLHIEAKRLE TAGATLKGGK VKLDVDDVKL
GGVYEAGSSY ENKSSTPLGS LFAILSSTTE TNQSAHANHY GTRIEAGTLE GKMQNLEIEG
GSVDAAHTDL SVARDARFKA AADFAHAEHE KDVRQLSLGA KVGAGGYEAG FSLGSESGLE
AHAGRGMTAG AEVKVGYRAS HEQSSETEKS YRNANLNFGG GSVEAGNVLD IGGADINRNR
YGGAAKGNAG TEEALRMRAK KVESTKYVSE QTSQSSGWSV EVASTASARS SLLTAATRLG
DSVAQNVEDG REIRGELMAA QVAAEATQLV TADTAAVALS AGISADFDSS HSRSTSQNTQ
YLGGNLSIEA TEGDATLVGA KFGGGDQVSL KAAKSVNLMA AESTFESYSE SHNFHASADA
NLGANAVQGA VGLGLTAGMG TSHQITNETG KTYAGTSVDA ANVSIDAGKD LNLSGSRVRG
KHVVLDVEGD INATSKQDER NYNSSGGGWD ASAGVAIQNR TLVAPVGSAG FNFNTEHDNS
RLTNDGAAGV VASDGLTGHV KGDANLTGAT IADLSGKGNL KVDGAVNAQN LKDYRDKDGG
SGGLNVGISS TTLAPTVGVA FGRVAGEDYQ AEQRATIDVG QTKDPARLQV GGGVKGTLNQ
DAAQATVVQR NKHWAGGGSE FSVAGKSLKK KNQVRPVETP TPDVVDGPPS RPTTPPASPQ
PIRATVEVSS PPPVSVATVE VVPRPKVETA QPLPPRPVAA QVVPVTPPKV EVAKVEVVPR
PKVETAQPLP PRPVVAEKVT TPAVQPQLAK VETVQPVKPE TTKPLPKPLP VAKVTKAPPP
VVETAQPLPP VKPQKATPGP VAEVGKATVT TVQVQSAPPK PAPVAKQPAP APKPKPKPKP
KAERPKPGKT TPLSGRHVVQ QQVQVLQRQA SDINNTKSLP GGKLPKPVTV KLTDENGKPQ
TYTINRREDL MKLNGKVLST KTTLGLEQTF RLRVEDIGGK NYRVFYETNK
