ID   095R_FRG3G              Reviewed;         363 AA.
AC   Q6GZN0;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 66.
DE   RecName: Full=Putative RAD2-like endonuclease 095R;
DE            EC=3.1.-.-;
GN   ORFNames=FV3-095R;
OS   Frog virus 3 (isolate Goorha) (FV-3).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Iridoviridae; Alphairidovirinae; Ranavirus.
OX   NCBI_TaxID=654924;
OH   NCBI_TaxID=30343; Dryophytes versicolor (chameleon treefrog).
OH   NCBI_TaxID=8404; Lithobates pipiens (Northern leopard frog) (Rana pipiens).
OH   NCBI_TaxID=45438; Lithobates sylvaticus (Wood frog) (Rana sylvatica).
OH   NCBI_TaxID=8316; Notophthalmus viridescens (Eastern newt) (Triturus viridescens).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15165820; DOI=10.1016/j.virol.2004.02.019;
RA   Tan W.G., Barkman T.J., Gregory Chinchar V., Essani K.;
RT   "Comparative genomic analyses of frog virus 3, type species of the genus
RT   Ranavirus (family Iridoviridae).";
RL   Virology 323:70-84(2004).
CC   -!- FUNCTION: Probable endonuclease. {ECO:0000305}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Note=Binds 2 magnesium ions per subunit. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. {ECO:0000305}.
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DR   EMBL; AY548484; AAT09755.1; -; Genomic_DNA.
DR   RefSeq; YP_031674.1; NC_005946.1.
DR   SMR; Q6GZN0; -.
DR   GeneID; 2947788; -.
DR   KEGG; vg:2947788; -.
DR   Proteomes; UP000008770; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR006086; XPG-I_dom.
DR   InterPro; IPR006084; XPG/Rad2.
DR   InterPro; IPR006085; XPG_DNA_repair_N.
DR   PANTHER; PTHR11081; PTHR11081; 1.
DR   Pfam; PF00867; XPG_I; 1.
DR   Pfam; PF00752; XPG_N; 1.
DR   PRINTS; PR00853; XPGRADSUPER.
DR   SMART; SM00279; HhH2; 1.
DR   SMART; SM00484; XPGI; 1.
DR   SMART; SM00485; XPGN; 1.
DR   SUPFAM; SSF47807; SSF47807; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Host nucleus; Hydrolase; Magnesium; Metal-binding; Nuclease;
KW   Reference proteome.
FT   CHAIN           1..363
FT                   /note="Putative RAD2-like endonuclease 095R"
FT                   /id="PRO_0000410578"
SQ   SEQUENCE   363 AA;  40621 MW;  A200449B8156A014 CRC64;
     MGIKGLKPLL RSYGVHEYTV PLSQMSGKTI AVDGTFLLHK YKNCHSVPWH YLTLYTLSNL
     RLRNVKVLFI FDGMSPPEKS REKSNRRCRK QALMEKGTLV KAQLEVWKKD GGEQAPELAA
     VSERLVKTRG LDPSLTDPET VQVLTDYVDN MSRDTRVTSD DYELMRRSLD AFGFPYADAP
     DEAELCCVRV VQMGIADAPM TIDSDALACG ALHGVDVVYT DLHGETLTAM STSKSKEALG
     LNGEQFMDLC VMCGTDFNQR VHKLGPVTAL KLIKAHGSIE NIPSAAPSMS CLEAVRTREI
     LSGGDMESRR KDYEAMVQKP VSAELIRSVF PPEFLDKLLH ENWQLRDAMK RMAPEAFEKC
     KRK