FHAD1_HUMAN
ID FHAD1_HUMAN Reviewed; 1412 AA.
AC B1AJZ9; Q0P6F5; Q8N8D3; Q8N9T6; Q8NA05;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Forkhead-associated domain-containing protein 1;
DE Short=FHA domain-containing protein 1;
GN Name=FHAD1; Synonyms=KIAA1937;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 299-768 (ISOFORM 1), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 730-1412 (ISOFORM 4), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 985-1412 (ISOFORM 3).
RC TISSUE=Small intestine, Testis, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=B1AJZ9-1; Sequence=Displayed;
CC Name=3;
CC IsoId=B1AJZ9-3; Sequence=VSP_035369;
CC Name=4;
CC IsoId=B1AJZ9-4; Sequence=VSP_035366;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04126.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC04242.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC04913.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL031283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL158174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL391094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK093300; BAC04126.1; ALT_INIT; mRNA.
DR EMBL; AK093883; BAC04242.1; ALT_INIT; mRNA.
DR EMBL; AK096961; BAC04913.1; ALT_INIT; mRNA.
DR RefSeq; NP_443161.1; NM_052929.1. [B1AJZ9-1]
DR AlphaFoldDB; B1AJZ9; -.
DR SMR; B1AJZ9; -.
DR BioGRID; 125377; 6.
DR IntAct; B1AJZ9; 3.
DR STRING; 9606.ENSP00000351770; -.
DR iPTMnet; B1AJZ9; -.
DR PhosphoSitePlus; B1AJZ9; -.
DR BioMuta; FHAD1; -.
DR EPD; B1AJZ9; -.
DR jPOST; B1AJZ9; -.
DR MassIVE; B1AJZ9; -.
DR PaxDb; B1AJZ9; -.
DR PeptideAtlas; B1AJZ9; -.
DR PRIDE; B1AJZ9; -.
DR ProteomicsDB; 3005; -. [B1AJZ9-1]
DR ProteomicsDB; 3006; -. [B1AJZ9-3]
DR ProteomicsDB; 3007; -. [B1AJZ9-4]
DR Antibodypedia; 63146; 93 antibodies from 13 providers.
DR DNASU; 114827; -.
DR Ensembl; ENST00000358897.8; ENSP00000351770.4; ENSG00000142621.21. [B1AJZ9-1]
DR Ensembl; ENST00000375998.8; ENSP00000365166.4; ENSG00000142621.21. [B1AJZ9-1]
DR GeneID; 114827; -.
DR KEGG; hsa:114827; -.
DR UCSC; uc001awb.2; human. [B1AJZ9-1]
DR CTD; 114827; -.
DR DisGeNET; 114827; -.
DR GeneCards; FHAD1; -.
DR HGNC; HGNC:29408; FHAD1.
DR HPA; ENSG00000142621; Tissue enhanced (choroid plexus, fallopian tube, testis).
DR neXtProt; NX_B1AJZ9; -.
DR OpenTargets; ENSG00000142621; -.
DR PharmGKB; PA142671762; -.
DR VEuPathDB; HostDB:ENSG00000142621; -.
DR eggNOG; ENOG502QR8Q; Eukaryota.
DR GeneTree; ENSGT00940000154171; -.
DR HOGENOM; CLU_005776_0_0_1; -.
DR InParanoid; B1AJZ9; -.
DR OMA; AQMCDIS; -.
DR OrthoDB; 1273737at2759; -.
DR PhylomeDB; B1AJZ9; -.
DR PathwayCommons; B1AJZ9; -.
DR SignaLink; B1AJZ9; -.
DR BioGRID-ORCS; 114827; 2 hits in 252 CRISPR screens.
DR ChiTaRS; FHAD1; human.
DR GenomeRNAi; 114827; -.
DR Pharos; B1AJZ9; Tdark.
DR PRO; PR:B1AJZ9; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; B1AJZ9; protein.
DR Bgee; ENSG00000142621; Expressed in right uterine tube and 123 other tissues.
DR ExpressionAtlas; B1AJZ9; baseline and differential.
DR Genevisible; B1AJZ9; HS.
DR CDD; cd00060; FHA; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR Pfam; PF00498; FHA; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF49879; SSF49879; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..1412
FT /note="Forkhead-associated domain-containing protein 1"
FT /id="PRO_0000349365"
FT DOMAIN 18..69
FT /note="FHA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT REGION 106..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1086..1110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1372..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 250..466
FT /evidence="ECO:0000255"
FT COILED 692..963
FT /evidence="ECO:0000255"
FT COILED 999..1099
FT /evidence="ECO:0000255"
FT COILED 1141..1169
FT /evidence="ECO:0000255"
FT COILED 1292..1360
FT /evidence="ECO:0000255"
FT COMPBIAS 955..971
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1378..1395
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1396..1412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 758..793
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_035366"
FT VAR_SEQ 1375..1412
FT /note="VGTRKASLKMDQEREMLRKETSSKSSQSLLHSKPSGKY -> MRKLRLRELR
FT GAQVHTAAGKDSWDLTPDPSDPGSPAVCRVGRKCRGARTEKRKRIDTLQLCLQRERQAG
FT PAPPACSLNG (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_035369"
FT VARIANT 763
FT /note="E -> K (in dbSNP:rs12126178)"
FT /id="VAR_046372"
FT CONFLICT 1004
FT /note="I -> L (in Ref. 2; BAC04913)"
FT /evidence="ECO:0000305"
FT CONFLICT 1366
FT /note="I -> V (in Ref. 2; BAC04913)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1412 AA; 161904 MW; 03BE058D84CF65AA CRC64;
MKAYLKSAEG FFVLNKSTTI GRHENSDLVL QSPDIDNHHA LIEYNEAECS FVLQDFNSRN
GTFVNECHIQ NVAVKLIPGD ILRFGSAGLT YELVIENPPP VSFPWMRGPA PWPGPQPPRA
TQQPNQAPPP SHIPFHQGVQ PAPMQRSWSQ AFPRPTVVLP ASHRRPVSAN KEMFSFVVDD
ARKPPVIKQV WTNAMKLSEK SVAEGIPGAV PPAEIYVEED LAQQDKDEII LLLGKEVSRL
SDYEIESKYK DVIIANLQNE VAELSQKVSE TTTSRQNEKE ISQKCQVLDE DIDAKQKEIQ
SLKSQISALQ KGYSKVLCQT LSERNSEITS LKNEGENLKR DNAITSGMVS SLQKDILAKD
EQVQQLKEEV SHLKSQNKDK DHQLEALGSR CSVLKEELKQ EDAHRELREA QEKELKLCKT
QIQDMEKEMK KLRAELRKSC TEQSVISRTL REKSKVEEKL QEDSRRKLLQ LQEMGNRESV
IKINLERAVG QLEHFRSQVI KATYGRAKPF RDKPVTDQQL IEKITQVTED NINFQQKKWT
LQKETQLSNS KQEETTENIE KLRTSLDSCQ ACMKISCCSH DLKKEVDLLQ HLQVSPPVSG
LQKVVLDVLR HALSWLEEVE QLLRDLGILP SSPNKDQVQQ FSGNSAVFTA GKAAGASGRE
GEAERGEARA RGEAQSQNQA TDGREGGKAL EEYITQERNR AKETLEEERK RMQELESLLA
QQKKALAKSI TQEKNRVKEA LEEEQTRVQE LEERLARQKE VLESSIAHEK RKAKEALESE
KRKVQDLENH LTQQKEISES NIAYEKRKAK EAMEKEKKKV QDLENRLTKQ KEELELKEQK
EDVLNNKLSD ALAMVEETQK TKATESLKAE SLALKLNETL AELETTKTKM IMVEERLILQ
QKMVKALQDE QESQRHGFEE EIMEYKEQIK QHAQTIVSLE EKLQKVTQHH KKIEGEIATL
KDNDPAPKEE RPQDPLVAPM TESSAKDMAY EHLIDDLLAA QKEILSQQEV IMKLRKDLTE
AHSRMSDLRG ELNEKQKMEL EQNVVLVQQQ SKELSVLKEK MAQMSSLVEK KDRELKALEE
ALRASQEKHR LQLNTEKEQK PRKKTQTCDT SVQIEPVHTE AFSSSQEQQS FSDLGVRCKG
SRHEEVIQRQ KKALSELRAR IKELEKARSP DHKDHQNESF LDLKNLRMEN NVQKILLDAK
PDLPTLSRIE ILAPQNGLCN ARFGSAMEKS GKMDVAEALE LSEKLYLDMS KTLGSLMNIK
NMSGHVSMKY LSRQEREKVN QLRQRDLDLV FDKITQLKNQ LGRKEELLRG YEKDVEQLRR
SKVSIEMYQS QVAKLEDDIY KEAEEKALLK EALERMEHQL CQEKRINRAI RQQKVGTRKA
SLKMDQEREM LRKETSSKSS QSLLHSKPSG KY
