FHAD1_MOUSE
ID FHAD1_MOUSE Reviewed; 1420 AA.
AC A6PWD2; A2AAC3; Q3UFH8; Q8BLA4; Q8CHV8; Q9CUV2;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Forkhead-associated domain-containing protein 1;
DE Short=FHA domain-containing protein 1;
GN Name=Fhad1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1-801 (ISOFORM 4).
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, Hippocampus, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=A6PWD2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6PWD2-2; Sequence=VSP_035371, VSP_035375, VSP_035376,
CC VSP_035377;
CC Name=3;
CC IsoId=A6PWD2-3; Sequence=VSP_035373, VSP_035374;
CC Name=4;
CC IsoId=A6PWD2-4; Sequence=VSP_035372;
CC Name=5;
CC IsoId=A6PWD2-5; Sequence=VSP_035370, VSP_035376, VSP_035377;
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DR EMBL; AK013832; BAB29008.1; -; mRNA.
DR EMBL; AK045799; BAC32497.1; -; mRNA.
DR EMBL; AK148490; BAE28583.1; -; mRNA.
DR EMBL; AL645731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL663037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC038692; AAH38692.1; -; mRNA.
DR CCDS; CCDS51349.1; -. [A6PWD2-1]
DR RefSeq; NP_808536.2; NM_177868.4. [A6PWD2-1]
DR RefSeq; XP_006539019.1; XM_006538956.3. [A6PWD2-1]
DR AlphaFoldDB; A6PWD2; -.
DR SMR; A6PWD2; -.
DR BioGRID; 236875; 1.
DR IntAct; A6PWD2; 1.
DR STRING; 10090.ENSMUSP00000101406; -.
DR iPTMnet; A6PWD2; -.
DR PhosphoSitePlus; A6PWD2; -.
DR EPD; A6PWD2; -.
DR MaxQB; A6PWD2; -.
DR PaxDb; A6PWD2; -.
DR PRIDE; A6PWD2; -.
DR ProteomicsDB; 271759; -. [A6PWD2-1]
DR ProteomicsDB; 271760; -. [A6PWD2-2]
DR ProteomicsDB; 271761; -. [A6PWD2-3]
DR ProteomicsDB; 271762; -. [A6PWD2-4]
DR ProteomicsDB; 271763; -. [A6PWD2-5]
DR Antibodypedia; 63146; 93 antibodies from 13 providers.
DR Ensembl; ENSMUST00000036701; ENSMUSP00000036224; ENSMUSG00000051435. [A6PWD2-2]
DR Ensembl; ENSMUST00000105779; ENSMUSP00000101405; ENSMUSG00000051435. [A6PWD2-1]
DR Ensembl; ENSMUST00000105780; ENSMUSP00000101406; ENSMUSG00000051435. [A6PWD2-1]
DR GeneID; 329977; -.
DR KEGG; mmu:329977; -.
DR UCSC; uc008vpm.1; mouse. [A6PWD2-5]
DR UCSC; uc008vpn.1; mouse. [A6PWD2-2]
DR UCSC; uc008vpp.1; mouse. [A6PWD2-3]
DR UCSC; uc012dog.2; mouse. [A6PWD2-1]
DR CTD; 114827; -.
DR MGI; MGI:1920323; Fhad1.
DR VEuPathDB; HostDB:ENSMUSG00000051435; -.
DR eggNOG; ENOG502QR8Q; Eukaryota.
DR GeneTree; ENSGT00940000154171; -.
DR HOGENOM; CLU_005776_0_0_1; -.
DR InParanoid; A6PWD2; -.
DR OMA; AQMCDIS; -.
DR OrthoDB; 1273737at2759; -.
DR PhylomeDB; A6PWD2; -.
DR TreeFam; TF328548; -.
DR BioGRID-ORCS; 329977; 0 hits in 73 CRISPR screens.
DR PRO; PR:A6PWD2; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; A6PWD2; protein.
DR Bgee; ENSMUSG00000051435; Expressed in testis and 64 other tissues.
DR Genevisible; A6PWD2; MM.
DR CDD; cd00060; FHA; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR Pfam; PF00498; FHA; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF49879; SSF49879; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..1420
FT /note="Forkhead-associated domain-containing protein 1"
FT /id="PRO_0000349366"
FT DOMAIN 18..69
FT /note="FHA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT REGION 932..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1053..1074
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1340..1363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1376..1420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 241..495
FT /evidence="ECO:0000255"
FT COILED 646..915
FT /evidence="ECO:0000255"
FT COILED 1003..1060
FT /evidence="ECO:0000255"
FT COILED 1111..1140
FT /evidence="ECO:0000255"
FT COILED 1256..1335
FT /evidence="ECO:0000255"
FT COMPBIAS 1053..1067
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1406..1420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..825
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_035370"
FT VAR_SEQ 1..696
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_035371"
FT VAR_SEQ 1..564
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_035372"
FT VAR_SEQ 450..463
FT /note="EEKLQEDSRRKLLQ -> RASRKLDCVHDNGR (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_035373"
FT VAR_SEQ 464..1420
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_035374"
FT VAR_SEQ 697
FT /note="A -> MLEVEKQTTQGPGRVHSLPWQQADSTAAVGLQ (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_035375"
FT VAR_SEQ 1056..1061
FT /note="ASQEKP -> CGKGSV (in isoform 2 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_035376"
FT VAR_SEQ 1062..1420
FT /note="Missing (in isoform 2 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_035377"
FT CONFLICT 755
FT /note="R -> G (in Ref. 1; BAE28583)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1420 AA; 163728 MW; 6F0595B646BDA4D0 CRC64;
MKAYLKSADG FFVLNKSTTI GKHADSDLVL QSADIDNHHA LIEFNEAEGT FVLQDFNSRN
GTFVNECHIQ NVAVKLIPGD ILRFGSAGMT YELVIENPSP VSCPWVRGPA PWPSPQPHLS
SSPPDMPFHH GIQPATVQRS WSQGCPRPTM VPPAPHQRPM SASGKMFSFV MDPKSPVINQ
VWANAMDMSE QCMMDGLSGT IPPTEIFMDH DLSQQDKDEI ILLLGREVNR LSDFEMESKY
KDALIMNLQA EVADLSQRLS ETAAVAAARQ SNRCDPKLQG VDEGDDLRQK EIESMKSQIN
ALQKGYSQVL SQTLAERNTE IESLKNEGEN LKRDHAITSG MVTSLQKDMS ARNEQVQQLQ
EEVNRLRIEN REKEYQLEAL SSRCSVMKEE LRKEEAQKDR REAQEKELKL CRSQMQDMEK
EVRKLREELK KNYMGQNIIS KTLREKNKVE EKLQEDSRRK LLQLQEMGNR ENLIKINLER
AVGQLENFRN QVIKATFGKT KPFRDKPITD QQLIEKIIQV TEDNLSFQQR KWTLQRETHL
HPKQEETMHS VEKLRVLLDK CQACMRDSCS SIDLKKEVEL LQHLPLSPLV SGLQKTVVNI
LRVSLSWLEE TEQLLGDLDI ELSDSDKGFS LCLIYLLEHY KKIMSQSQDL QAQMNASRET
QKSLRQEHLA EKEKLAEKLE QEEKLKAKIQ QLTEEKAALE ESIGQEKSRS EEALEKAQAR
VRELENHLAS QKEALENSVA QEKRKMREML EAERRKAQDL ENQLTQQKEI SENNTYEKLK
MRDTLEKEKR KIQDLENRLT KQKEEIELKE QKENVLNNKL KDALVMVEDA QQMKTTESQR
AETLALKLKE TLAELETTKT KMILTDDRLK LQQQSMKALQ DERESQKHGF EEEISEYKEQ
IKQHSQTIVS LEERLCQVTQ YYQKIEGEIT TLKNNDTGPK EEASQDLTAG PPLDSGDKEI
ACDHLIDDLL MAQKEILSQQ EIIMKLRTDL GEAHSRMSDL RGELSEKQKM ELERQVALVR
QQSGELSMLK AKVAQTTGLM EKKDRELKVL REALRASQEK PRPHLSTEQK PRTLSQKCDI
SLQIEPAHPD SFSSFQEEQS FSDLGVKCKG SRHEETIQRQ RKALSELRTR VRELEKANSC
NHKDHVNESF LELRTLRMEK NVQKILLDAK PDLTTLARVE IRPPQNSPFN SGSTLVMEKS
VKTDAGEALE LSEKLYTDMI KTLGSLMNIK DMSSHTSLKH LSPKEREKVN HLRQKDLDLV
FDKITQLKTR LQRKEELLKG YEQELEQLRH SKVSVQMYQT QVAKLEDDVH KEAEEKALLK
EALERTEQQL SQERRFNRVF KQQKDRGEDP EQRNMSYSPF KDNEKQRRLF VEMVKSKMQN
SSVQAGAKKA TLKTGQERET KKEAYKSTQS LSFVKPGGKN
