ID   FHCC_METEA              Reviewed;         265 AA.
AC   C5B135;
DT   06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Formyltransferase/hydrolase complex Fhc subunit C;
GN   Name=fhcC; OrderedLocusNames=MexAM1_META1p1755;
OS   Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB
OS   9133 / AM1) (Methylobacterium extorquens).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylorubrum.
OX   NCBI_TaxID=272630;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1;
RX   PubMed=19440302; DOI=10.1371/journal.pone.0005584;
RA   Vuilleumier S., Chistoserdova L., Lee M.-C., Bringel F., Lajus A., Zhou Y.,
RA   Gourion B., Barbe V., Chang J., Cruveiller S., Dossat C., Gillett W.,
RA   Gruffaz C., Haugen E., Hourcade E., Levy R., Mangenot S., Muller E.,
RA   Nadalig T., Pagni M., Penny C., Peyraud R., Robinson D.G., Roche D.,
RA   Rouy Z., Saenampechek C., Salvignol G., Vallenet D., Wu Z., Marx C.J.,
RA   Vorholt J.A., Olson M.V., Kaul R., Weissenbach J., Medigue C.,
RA   Lidstrom M.E.;
RT   "Methylobacterium genome sequences: a reference blueprint to investigate
RT   microbial metabolism of C1 compounds from natural and industrial sources.";
RL   PLoS ONE 4:E5584-E5584(2009).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-16, FUNCTION IN FORMALDEHYDE DEGRADATION, AND
RP   SUBUNIT.
RX   PubMed=11532013; DOI=10.1046/j.1432-1327.2001.02401.x;
RA   Pomper B.K., Vorholt J.A.;
RT   "Characterization of the formyltransferase from Methylobacterium extorquens
RT   AM1.";
RL   Eur. J. Biochem. 268:4769-4775(2001).
RN   [3]
RP   FUNCTION.
RX   PubMed=12123819; DOI=10.1016/s0014-5793(02)02962-9;
RA   Pomper B.K., Saurel O., Milon A., Vorholt J.A.;
RT   "Generation of formate by the formyltransferase/hydrolase complex (Fhc)
RT   from Methylobacterium extorquens AM1.";
RL   FEBS Lett. 523:133-137(2002).
CC   -!- FUNCTION: Involved in the transformation of 5-formyl
CC       tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and
CC       formate via the formylmethanofuran (formyl-MFR).
CC       {ECO:0000269|PubMed:11532013, ECO:0000269|PubMed:12123819}.
CC   -!- PATHWAY: One-carbon metabolism; formaldehyde degradation; formate from
CC       formaldehyde (H(4)MPT route): step 4/5.
CC   -!- SUBUNIT: Octaheteromer. Part of the formyltransferase/hydrolase complex
CC       fhc; composed of FhcA, FhcB, FhcC and FhcD.
CC       {ECO:0000269|PubMed:11532013}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- MISCELLANEOUS: Although FhcB and FhcC do not possess a formylMFR
CC       dehydrogenase (Fmd) activity and have an unknown function, they are
CC       required for the stability of the complex.
CC       {ECO:0000305|PubMed:11532013}.
CC   -!- SIMILARITY: Belongs to the FwdC/FmdC family. {ECO:0000305}.
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DR   EMBL; CP001510; ACS39599.1; -; Genomic_DNA.
DR   RefSeq; WP_003597591.1; NC_012808.1.
DR   AlphaFoldDB; C5B135; -.
DR   SMR; C5B135; -.
DR   STRING; 272630.MexAM1_META1p1755; -.
DR   EnsemblBacteria; ACS39599; ACS39599; MexAM1_META1p1755.
DR   KEGG; mea:Mex_1p1755; -.
DR   eggNOG; COG2218; Bacteria.
DR   HOGENOM; CLU_072248_1_0_5; -.
DR   OMA; VNGDAGM; -.
DR   OrthoDB; 1706418at2; -.
DR   UniPathway; UPA00562; UER00704.
DR   Proteomes; UP000009081; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0018493; F:formylmethanofuran dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   GO; GO:0046294; P:formaldehyde catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0015948; P:methanogenesis; IEA:InterPro.
DR   GO; GO:0006730; P:one-carbon metabolic process; IDA:UniProtKB.
DR   Gene3D; 2.160.20.60; -; 1.
DR   InterPro; IPR017550; Formylmethanofuran_DH_suC.
DR   InterPro; IPR002489; Glu_synth_asu_C.
DR   InterPro; IPR036485; Glu_synth_asu_C_sf.
DR   Pfam; PF01493; GXGXG; 1.
DR   SUPFAM; SSF69336; SSF69336; 1.
DR   TIGRFAMs; TIGR03122; one_C_dehyd_C; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; One-carbon metabolism.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:11532013"
FT   CHAIN           2..265
FT                   /note="Formyltransferase/hydrolase complex Fhc subunit C"
FT                   /id="PRO_0000421573"
SQ   SEQUENCE   265 AA;  26463 MW;  8B6385E0C1969FDB CRC64;
     MSTLRLRGDL PERVDLLNIT PLALSGLSEA EAGKLAIGTS RRGLTLGDVF EISLDGSDSL
     VIEGGSARLD RVGAALSQGS IRVEGDVGQR LGEGMAAGSL TVTGSAGPYA GTGATGGTIT
     IEGDAGDHAG GAVYAAKAGL DGATLVIKGA AGDHLGDRMR RGMILAGSAG AFAASRMIAG
     TIVVSGALGD HPGYGMRRGT LIAGSHGTLL PTFVETGTPD LVFVRLLAQS LKHLGAAQAS
     LLSGTLRRYS GDLATLGKGE LFVPA