FHI1A_MOUSE
ID FHI1A_MOUSE Reviewed; 1081 AA.
AC Q505K2; Q8BZ23;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=FHF complex subunit HOOK interacting protein 1A {ECO:0000305};
DE Short=FHIP1A {ECO:0000305};
GN Name=Fhip1a; Synonyms=Fam160a1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 184-1081.
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 259-1081.
RC STRAIN=C57BL/6J; TISSUE=Vagina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Probable component of the FTS/Hook/FHIP complex (FHF
CC complex). FHF complex promotes the distribution of AP-4 complex to the
CC perinuclear area of the cell. {ECO:0000250|UniProtKB:Q05DH4}.
CC -!- SUBUNIT: May be a component of the FTS/Hook/FHIP complex (FHF complex),
CC composed of AKTIP/FTS, FHIP1B, and one or more members of the Hook
CC family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with
CC AKTIP/FTS. {ECO:0000250|UniProtKB:Q05DH4}.
CC -!- SIMILARITY: Belongs to the FHIP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC29618.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC102338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC094511; AAH94511.1; -; mRNA.
DR EMBL; AK036881; BAC29618.1; ALT_INIT; mRNA.
DR CCDS; CCDS17442.2; -.
DR RefSeq; NP_766270.2; NM_172682.3.
DR RefSeq; XP_006501396.1; XM_006501333.3.
DR RefSeq; XP_011238384.1; XM_011240082.2.
DR AlphaFoldDB; Q505K2; -.
DR STRING; 10090.ENSMUSP00000113235; -.
DR iPTMnet; Q505K2; -.
DR PhosphoSitePlus; Q505K2; -.
DR MaxQB; Q505K2; -.
DR PaxDb; Q505K2; -.
DR PeptideAtlas; Q505K2; -.
DR PRIDE; Q505K2; -.
DR ProteomicsDB; 275973; -.
DR Antibodypedia; 48311; 12 antibodies from 7 providers.
DR DNASU; 229488; -.
DR Ensembl; ENSMUST00000094148; ENSMUSP00000091700; ENSMUSG00000051000.
DR Ensembl; ENSMUST00000118408; ENSMUSP00000113235; ENSMUSG00000051000.
DR GeneID; 229488; -.
DR KEGG; mmu:229488; -.
DR UCSC; uc008pqu.2; mouse.
DR CTD; 729830; -.
DR MGI; MGI:2444746; Fam160a1.
DR VEuPathDB; HostDB:ENSMUSG00000051000; -.
DR eggNOG; KOG3695; Eukaryota.
DR GeneTree; ENSGT00950000182936; -.
DR HOGENOM; CLU_007807_0_0_1; -.
DR InParanoid; Q505K2; -.
DR OMA; RMPSLVQ; -.
DR OrthoDB; 141539at2759; -.
DR PhylomeDB; Q505K2; -.
DR TreeFam; TF313941; -.
DR BioGRID-ORCS; 229488; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Fam160a1; mouse.
DR PRO; PR:Q505K2; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q505K2; protein.
DR Bgee; ENSMUSG00000051000; Expressed in animal zygote and 122 other tissues.
DR ExpressionAtlas; Q505K2; baseline and differential.
DR Genevisible; Q505K2; MM.
DR GO; GO:1905719; P:protein localization to perinuclear region of cytoplasm; ISO:MGI.
DR InterPro; IPR019384; FHIP.
DR InterPro; IPR045669; FHIP_C.
DR InterPro; IPR045668; FHIP_KELAA_motif.
DR PANTHER; PTHR21705; PTHR21705; 1.
DR Pfam; PF19314; DUF5917; 1.
DR Pfam; PF19311; KELAA; 1.
DR Pfam; PF10257; RAI16-like; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..1081
FT /note="FHF complex subunit HOOK interacting protein 1A"
FT /id="PRO_0000319579"
FT REGION 474..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 863..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..705
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 723..765
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1081 AA; 120219 MW; 2D8528C959F7B499 CRC64;
MMSSVSTESK LQQAVSLKGV DPETCMIVFK NHWAQVVKIL EKHDPLKNTQ AKYGSIPPDE
ASAVQNYVEH MLFLLIEEQA KDAAMGPILE FVVCENIMEK LFLWSLRREF TDETKLEQLK
MYEMLVTQSY QPLLHHKPIL KPLMMLLSSC SGTATPAVEG KLVVLLNQLC SILAKDPSIL
ELFFHTSEDQ GAANFLIFSL LIPFIHREGT VGQQARDALL FIMSLSAENS MVANHIVENT
YFCPVLATGL SGLYSSLPTK LEEKGEDWHC ILKDDWLLLP ALVQFMNSLE FCNAVIQVAH
PLIRTQLVSY IYNGFLVPVL APALHKVTVE EVMTTTAYLD LFLRSISEPA LLEIFLRFIL
LHRHENVHIL DTLTSRINTP FRLCVVSLAL FRTLIGLHCE DVMLQLVLRY LVPCNHMMLS
QRWAVKERDC YSVSAAKLLA LTPVCCASGI TLTLGNQERD YILWSKCMHD GSGSEEQLLP
ETPCSPSSPS PPPPPAPAAC IVEYGKALDI SYLQYLWEAH TNILHCMRDC RVWSALYDGD
SPDPETFLQS LSEESRENSG HPEARLPQQS VRTSGQTKDK SQSELEWDDS YDTGISSGAD
VGSPGPDDEV ETPAPPAPID PPKHIQEMKK NAILLFKGSY IEESDFQDDV MVYRLCAEKD
TEDTTEPQKD TSEPQGDTLE PLEDTSEQQE DTSEQLEDTS ELQEDTAEPQ GDTADPTAEA
QPKLQPEAQS LPTSNGPLSS PDPETESQPS RESSDLCQNT FSEAKPENEP GVALALDSEL
IATTFEAEPQ SELAVVSTES EDFIAQYDQI IQELDSGTEG LTEQSIPISE PSLLTQQEER
REECKEEEDD DFDSLMAATP AVEAGSSPFG VGEDTAFSSR HPVRTQSTPF TGPFISVVLS
KLENMLENSL HVNLLLIGII TQLASYPQPL LRSFLLNTNM VFQPSVRSLY QVLASVKNKI
EQFASVERDF PGLLIQAQQY LLFRVDMSDM APAALTKDPI QEISRPESDK TLLDGPPRVL
QPFLGNRAKV TRAPPNLPLP VKNTMLAAAL FPEFLKELAA LAQEHSILCY KILGDFEDSC
C
