FHI1B_BOVIN
ID FHI1B_BOVIN Reviewed; 973 AA.
AC A7YY62;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 52.
DE RecName: Full=FHF complex subunit HOOK interacting protein 1B;
DE Short=FHIP1B;
DE AltName: Full=FTS and Hook-interacting protein;
DE Short=FHIP;
GN Name=FHIP1B; Synonyms=FAM160A2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Ascending colon;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF
CC complex may function to promote vesicle trafficking and/or fusion via
CC the homotypic vesicular protein sorting complex (the HOPS complex). FHF
CC complex promotes the distribution of AP-4 complex to the perinuclear
CC area of the cell. {ECO:0000250|UniProtKB:Q8N612}.
CC -!- SUBUNIT: Component of the FTS/Hook/FHIP complex (FHF complex), composed
CC of AKTIP/FTS, FHIP1B, and one or more members of the Hook family of
CC proteins HOOK1, HOOK2, and HOOK3. The FHF complex associates with the
CC homotypic vesicular sorting complex (the HOPS complex).
CC {ECO:0000250|UniProtKB:Q8N612}.
CC -!- SIMILARITY: Belongs to the FHIP family. {ECO:0000305}.
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DR EMBL; BC151392; AAI51393.1; -; mRNA.
DR RefSeq; NP_001095961.1; NM_001102491.1.
DR AlphaFoldDB; A7YY62; -.
DR SMR; A7YY62; -.
DR STRING; 9913.ENSBTAP00000027334; -.
DR PaxDb; A7YY62; -.
DR PRIDE; A7YY62; -.
DR Ensembl; ENSBTAT00000027334; ENSBTAP00000027334; ENSBTAG00000020515.
DR GeneID; 508334; -.
DR KEGG; bta:508334; -.
DR CTD; 84067; -.
DR VEuPathDB; HostDB:ENSBTAG00000020515; -.
DR VGNC; VGNC:97271; FHIP1B.
DR eggNOG; KOG3695; Eukaryota.
DR GeneTree; ENSGT00950000182936; -.
DR InParanoid; A7YY62; -.
DR OMA; CLDWDSG; -.
DR OrthoDB; 141539at2759; -.
DR Proteomes; UP000009136; Chromosome 15.
DR Bgee; ENSBTAG00000020515; Expressed in neutrophil and 105 other tissues.
DR ExpressionAtlas; A7YY62; baseline.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0070695; C:FHF complex; ISS:UniProtKB.
DR GO; GO:0045022; P:early endosome to late endosome transport; ISS:UniProtKB.
DR GO; GO:0007032; P:endosome organization; ISS:UniProtKB.
DR GO; GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
DR GO; GO:0007040; P:lysosome organization; ISS:UniProtKB.
DR GO; GO:1905719; P:protein localization to perinuclear region of cytoplasm; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR019384; FHIP.
DR InterPro; IPR045669; FHIP_C.
DR InterPro; IPR045668; FHIP_KELAA_motif.
DR PANTHER; PTHR21705; PTHR21705; 1.
DR Pfam; PF19314; DUF5917; 1.
DR Pfam; PF19311; KELAA; 1.
DR Pfam; PF10257; RAI16-like; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Protein transport; Reference proteome; Transport.
FT CHAIN 1..973
FT /note="FHF complex subunit HOOK interacting protein 1B"
FT /id="PRO_0000379000"
FT REGION 466..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..610
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 467
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N612"
FT MOD_RES 510
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3U2I3"
FT MOD_RES 523
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3U2I3"
FT MOD_RES 529
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q66H54"
FT MOD_RES 533
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q66H54"
FT MOD_RES 859
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N612"
FT MOD_RES 898
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N612"
SQ SEQUENCE 973 AA; 105488 MW; CF13B4131D78C8CC CRC64;
MERMNWLSRL ASRGPGHRVP QGASLQTPVM ADPETCLMVF KNHWSQVVRI LERQGPRAAP
GGADDLSAVR NHTYQMLTLL AEDRAVPLVP TAPGPLLEFA LREDLLTRVL TWQLQWDELG
DGVEERRAEQ LKLFEMLVSE ARQPLLRHGP VREALLILLD ACGRPVPSSP ALDEGLVLLL
SQLCVCLARE PSLLEFFLQP PPEPGAAPRL LLFSRLVPFV HREGTLGQQA RDALLLLMAL
SAGSPTVGCY IADHSYFCPV LATGLSALYS SLPRKIEVPG DDWHCLRRED WLGVPALALF
MSSLEFCNAV IQVAHPLVQK QLVDYIHNGF LVPVMGPALH KTSVEEMIAS TAYLELFLRS
ISEPALLRTF LRFLLLHRHD THTILDTLVA RIGSNSRLCM VSLSLFRTLL NLSCEDVLLQ
LVLRYLVPCN HVMLSQKPAV RDVDLYGRAA DKFLSLIPRC CRHHASSPSR PEHASWARGP
GSPSVDSSSV VTVHRPSTPS RLALFLRQQS LGGSESPAPA PRSPGLATSP ASSPGRRPSP
VEEPGELEDN YLEYLREARR GVDRCVQACR TWSAPYDGER PPPEPSPVGS RTKKRSLLPE
EGRDNAGGGE EEELGSGGLA GGARESLGHL PPPQLNGLPG PWPEGAKKVR RVPKEGAGEP
LEDTSEGMAG LEGFGQELRE LEVALSNGGA GSEPPLEPSL PLEEEEAYES FTCSPEPPGP
FLSSPLRTLN QLPSQPFTGP FMAVLFAKLE NMLQNSVYVN FLLTGLVAQL ACHPQPLLRS
FLLNTNMVFQ PSVKSLLQVL GSVKNKIESF AASQEDFPAL LSKAKKYLIA RGKLDWTEGP
AAGPAPRRSD SLVKSRRPSL GELLLRHAHS PTRARQAAQM VLQPGRDGGA GLGLGGGSPG
ASTPVLPARG GAPERQGEAL RVKNAVYCAV IFPEFLKELA AISQAHAVTS PFLLDTSEEG
SGPPVSGFGP LNP
