FHI2A_MOUSE
ID FHI2A_MOUSE Reviewed; 764 AA.
AC Q8CDM8; Q3T9P9; Q68FM8; Q6P5D5; Q80TB5; Q8C8M2; Q8R1V3;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=FHF complex subunit HOOK interacting protein 2A;
DE Short=FHIP2A;
GN Name=Fhip2a; Synonyms=Fam160b1, Kiaa1600;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Adrenal gland, Spleen, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 365-764 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 69-764 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be required for proper functioning of the nervous system.
CC {ECO:0000250|UniProtKB:Q5W0V3}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CDM8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CDM8-2; Sequence=VSP_024592;
CC -!- SIMILARITY: Belongs to the FHIP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC32767.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BC079562; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK029835; BAC26638.1; -; mRNA.
DR EMBL; AK046518; BAC32767.1; ALT_FRAME; mRNA.
DR EMBL; AK172373; BAE42971.1; -; mRNA.
DR EMBL; BC023048; AAH23048.1; -; mRNA.
DR EMBL; BC062949; AAH62949.1; -; mRNA.
DR EMBL; BC079562; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK122530; BAC65812.1; -; mRNA.
DR CCDS; CCDS29925.1; -. [Q8CDM8-1]
DR RefSeq; NP_663480.3; NM_145505.4. [Q8CDM8-1]
DR AlphaFoldDB; Q8CDM8; -.
DR BioGRID; 230493; 1.
DR STRING; 10090.ENSMUSP00000048903; -.
DR iPTMnet; Q8CDM8; -.
DR PhosphoSitePlus; Q8CDM8; -.
DR EPD; Q8CDM8; -.
DR MaxQB; Q8CDM8; -.
DR PaxDb; Q8CDM8; -.
DR PeptideAtlas; Q8CDM8; -.
DR PRIDE; Q8CDM8; -.
DR ProteomicsDB; 271529; -. [Q8CDM8-1]
DR ProteomicsDB; 271530; -. [Q8CDM8-2]
DR Antibodypedia; 52360; 120 antibodies from 18 providers.
DR DNASU; 226252; -.
DR Ensembl; ENSMUST00000036407; ENSMUSP00000048903; ENSMUSG00000033478. [Q8CDM8-1]
DR GeneID; 226252; -.
DR KEGG; mmu:226252; -.
DR UCSC; uc008iac.2; mouse. [Q8CDM8-1]
DR CTD; 57700; -.
DR MGI; MGI:2147545; Fam160b1.
DR VEuPathDB; HostDB:ENSMUSG00000033478; -.
DR eggNOG; KOG3695; Eukaryota.
DR GeneTree; ENSGT00950000182936; -.
DR HOGENOM; CLU_023718_0_0_1; -.
DR InParanoid; Q8CDM8; -.
DR OMA; WFASRFP; -.
DR OrthoDB; 266554at2759; -.
DR PhylomeDB; Q8CDM8; -.
DR TreeFam; TF313941; -.
DR BioGRID-ORCS; 226252; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Fam160b1; mouse.
DR PRO; PR:Q8CDM8; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8CDM8; protein.
DR Bgee; ENSMUSG00000033478; Expressed in humerus cartilage element and 239 other tissues.
DR ExpressionAtlas; Q8CDM8; baseline and differential.
DR Genevisible; Q8CDM8; MM.
DR InterPro; IPR019384; FHIP.
DR InterPro; IPR045669; FHIP_C.
DR InterPro; IPR045668; FHIP_KELAA_motif.
DR PANTHER; PTHR21705; PTHR21705; 1.
DR Pfam; PF19314; DUF5917; 1.
DR Pfam; PF19311; KELAA; 1.
DR Pfam; PF10257; RAI16-like; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..764
FT /note="FHF complex subunit HOOK interacting protein 2A"
FT /id="PRO_0000284649"
FT REGION 190..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 524..764
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024592"
FT CONFLICT 95
FT /note="G -> R (in Ref. 1; BAC32767)"
FT /evidence="ECO:0000305"
FT CONFLICT 477
FT /note="H -> Y (in Ref. 1; BAE42971)"
FT /evidence="ECO:0000305"
FT CONFLICT 492
FT /note="L -> S (in Ref. 1; BAC32767)"
FT /evidence="ECO:0000305"
FT CONFLICT 518
FT /note="L -> Q (in Ref. 1; BAC26638)"
FT /evidence="ECO:0000305"
FT CONFLICT 548
FT /note="S -> T (in Ref. 1; BAE42971)"
FT /evidence="ECO:0000305"
FT CONFLICT 578
FT /note="D -> E (in Ref. 1; BAE42971)"
FT /evidence="ECO:0000305"
FT CONFLICT 607
FT /note="I -> V (in Ref. 1; BAE42971)"
FT /evidence="ECO:0000305"
FT CONFLICT 680
FT /note="I -> V (in Ref. 1; BAE42971)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 764 AA; 86017 MW; 90D4F625C02DD286 CRC64;
MFSKLTSILQ HAVEALAPSL PLQEDFVYHW KAITHYYIET SDDKAPVTDT NIPSHLEQML
DILVQEENER ESGETGPCME YLLHHKILET LYTLGKADCP PGMKQQVLVF YTKLLGRIRQ
PLLPHINVHR PVQKLIRLCG EVLATPTENE EIQFLCIVCA KLKQDPYLVN FFLENKSKSL
VSRGALSVIS EDGPKGQDPG SGDVSQCQQP QELSGATGVE PTESEEEPPH QMDDLSASLD
DLNVTSLPEA SAVRPNQDYN LVNSLLNLTR SPDGRIAVKA CEGLMLLVSL PEPAAAKCLA
QSTCLCELLT GRLTSLYKAL PQSVDPLDIE TVEAVNWGLD SYSHKEDASA FPGKRALISF
LSWFDYCDQL IKEAQKTAAV ALAKAIHERF FVGVMEPQLM QTSEMGILTS TALLHRIVRQ
VTSDVLLQEM VVFILGEQRE PETLSEISRH PLRHRLIEHC DHISDEISIM TLRMFEHLLQ
KPNEHILYNL VLRNLEERNY TENKPSCPED KDVVENGLIA GAVDLEEDPL FTDISPDNTL
PNQEWICSPR TSPDHPKNDG KTEVHKVVNS FLCLVPDDAK SSYHVEGTGY DTYLRDAHRQ
FRDYCAICSR WEWPGAPKPL EKCDLEAAFF EGHFLKVLFD RMGRILDQPY DVNLQVTSVL
SRLSLFPHPH THEYLLDPYI NLASGCRSLF SVIVRVVGDL MVRIQRIQDF TPKLLLVRKR
LLGLEPEGPI VDHITLLEGV IVLEEFCKEL AAIAFVKYHA SATP
