ID   FHI2B_DANRE             Reviewed;         735 AA.
AC   A0JPF5; B0UX70;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=FHF complex subunit HOOK interacting protein 2B;
DE            Short=FHIP2B;
DE   AltName: Full=RAI16-like protein;
DE   AltName: Full=Retinoic acid-induced protein 16;
GN   Name=fhip2b; Synonyms=fam160b2, rai16, rai16l;
GN   ORFNames=si:ch211-119d14.1, zgc:153945;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the FHIP family. {ECO:0000305}.
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DR   EMBL; CR354402; CAQ15446.1; -; Genomic_DNA.
DR   EMBL; BC127400; AAI27401.1; -; mRNA.
DR   RefSeq; NP_001071234.1; NM_001077766.1.
DR   AlphaFoldDB; A0JPF5; -.
DR   SMR; A0JPF5; -.
DR   STRING; 7955.ENSDARP00000078566; -.
DR   PaxDb; A0JPF5; -.
DR   Ensembl; ENSDART00000084131; ENSDARP00000078566; ENSDARG00000060029.
DR   GeneID; 777718; -.
DR   KEGG; dre:777718; -.
DR   CTD; 64760; -.
DR   ZFIN; ZDB-GENE-061110-76; fhip2b.
DR   eggNOG; KOG3695; Eukaryota.
DR   GeneTree; ENSGT00950000182936; -.
DR   InParanoid; A0JPF5; -.
DR   OMA; CDHLIME; -.
DR   OrthoDB; 266554at2759; -.
DR   PhylomeDB; A0JPF5; -.
DR   TreeFam; TF313941; -.
DR   PRO; PR:A0JPF5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 8.
DR   Bgee; ENSDARG00000060029; Expressed in muscle tissue and 20 other tissues.
DR   InterPro; IPR019384; FHIP.
DR   InterPro; IPR045669; FHIP_C.
DR   InterPro; IPR045668; FHIP_KELAA_motif.
DR   PANTHER; PTHR21705; PTHR21705; 1.
DR   Pfam; PF19314; DUF5917; 1.
DR   Pfam; PF19311; KELAA; 1.
DR   Pfam; PF10257; RAI16-like; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..735
FT                   /note="FHF complex subunit HOOK interacting protein 2B"
FT                   /id="PRO_0000284650"
FT   REGION          183..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        190..227
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   735 AA;  83627 MW;  CB84715A36346FC5 CRC64;
     MDMFNKVTAF LQQALETREP SINLLESFVD HWKAITNYYI ETTDESRAVK NTDIPWRLRQ
     MLDILVYEEK QQGEEAGPCM EYLLQHKILE TLCTLGKAQY PPGMSQQVMV FFSKVLSHIQ
     KPVLHLINVY RPVQKLINLC GLPHSQTEKE ESQFLFAVCT QVNKDPYVLN YILEIKNDSL
     KRSSSTSDEA AEKDCSGSSS PERASSPSSS SSACSLLSRS GAHPVSSPQE ATGMIPVLLH
     LEKSEKRRVA HRSLESLLLL VSSTQEDTGH LLAERTPLCD LLAQRLTELY LLIPSTIDPA
     DIHSFSVVQW RTRFTQDSTA ESQSFPGSEN VYRFFCFLDL CNELIKQAPK VLGVKMARAL
     HSQWLKGVIQ PHLLQMSEVG ILVHTTLLSC SVRHIHSPAL LEELVQFMLG SDTDSETRQH
     LHTHLLRYRL IEHCNHISDE ISITTLRLFE ELLQKPNRRI LSNLVLRNLE NRSYKLPGTG
     ASDERLRVES DLLDESEELE EDPFFPDMYD DSGDSNHEPL LSLPNVRERL NPNLHTQVVD
     TVNSFLCLVP QEAKTSHLVQ GAGYDTYVHD AHKVFKECTA LVRDWKWPDS AKATVNNPST
     DFYEGHFLHI LFDRIARILE QPYELNLQVT SVLSRLAVFP HPNLHEYLLD PYISLSPGAR
     SLFSTLVRVI GDLMQRIQNI TNVTDRLVVI RRQLMGLDEE SMVDHMTLLK GVIVLEEFCK
     ELAAVAFVKL PTEEQ