FHI2B_HUMAN
ID FHI2B_HUMAN Reviewed; 743 AA.
AC Q86V87; B2RDQ5; B3KNX1; Q2M211; Q71JB5; Q7L3J6; Q969T0; Q9H6W4;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=FHF complex subunit HOOK interacting protein 2B {ECO:0000305};
DE Short=FHIP2B;
DE AltName: Full=Retinoic acid-induced protein 16 {ECO:0000303|PubMed:22971576};
GN Name=FHIP2B {ECO:0000312|HGNC:HGNC:16492};
GN Synonyms=FAM160B2, RAI16 {ECO:0000303|PubMed:22971576}; ORFNames=FP13191;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-315.
RC TISSUE=Brain, Lung, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 182-743, AND VARIANT ALA-315.
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 298-743.
RC TISSUE=Hepatoma, Synovium, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=22971576; DOI=10.1093/carcin/bgs289;
RA Wang W., Zhao L.J., Yang Y., Wang R.Y., Ren H., Zhao P., Zhou W.P.,
RA Qi Z.T.;
RT "Retinoic acid induced 16 enhances tumorigenesis and serves as a novel
RT tumor marker for hepatocellular carcinoma.";
RL Carcinogenesis 33:2578-2585(2012).
CC -!- FUNCTION: Able to activate MAPK/ERK and TGFB signaling pathways
CC (PubMed:22971576). May regulate the activity of genes involved in
CC intestinal barrier function and immunoprotective inflammation (By
CC similarity). May play a role in cell proliferation (PubMed:22971576).
CC {ECO:0000250|UniProtKB:Q80YR2, ECO:0000269|PubMed:22971576}.
CC -!- TISSUE SPECIFICITY: Expressed in liver. {ECO:0000269|PubMed:22971576}.
CC -!- SIMILARITY: Belongs to the FHIP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH52237.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI12148.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI12148.2; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAQ06676.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAB15137.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAG38002.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAG51483.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC091171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC012865; AAH12865.3; -; mRNA.
DR EMBL; BC013350; AAH13350.2; -; mRNA.
DR EMBL; BC052237; AAH52237.1; ALT_INIT; mRNA.
DR EMBL; BC112147; AAI12148.2; ALT_SEQ; mRNA.
DR EMBL; AF495722; AAQ06676.1; ALT_FRAME; mRNA.
DR EMBL; AK025454; BAB15137.1; ALT_INIT; mRNA.
DR EMBL; AK315634; BAG38002.1; ALT_INIT; mRNA.
DR EMBL; AK055191; BAG51483.1; ALT_INIT; mRNA.
DR CCDS; CCDS6021.2; -.
DR RefSeq; NP_073586.5; NM_022749.5.
DR AlphaFoldDB; Q86V87; -.
DR BioGRID; 122273; 16.
DR IntAct; Q86V87; 3.
DR STRING; 9606.ENSP00000289921; -.
DR iPTMnet; Q86V87; -.
DR PhosphoSitePlus; Q86V87; -.
DR BioMuta; FAM160B2; -.
DR DMDM; 145566932; -.
DR EPD; Q86V87; -.
DR jPOST; Q86V87; -.
DR MassIVE; Q86V87; -.
DR MaxQB; Q86V87; -.
DR PaxDb; Q86V87; -.
DR PeptideAtlas; Q86V87; -.
DR PRIDE; Q86V87; -.
DR ProteomicsDB; 69977; -.
DR Antibodypedia; 9275; 103 antibodies from 23 providers.
DR DNASU; 64760; -.
DR Ensembl; ENST00000289921.8; ENSP00000289921.6; ENSG00000158863.22.
DR Ensembl; ENST00000450006.7; ENSP00000403288.3; ENSG00000158863.22.
DR GeneID; 64760; -.
DR KEGG; hsa:64760; -.
DR MANE-Select; ENST00000289921.8; ENSP00000289921.6; NM_022749.7; NP_073586.5.
DR UCSC; uc011kyx.3; human.
DR CTD; 64760; -.
DR GeneCards; FHIP2B; -.
DR HGNC; HGNC:16492; FHIP2B.
DR HPA; ENSG00000158863; Low tissue specificity.
DR neXtProt; NX_Q86V87; -.
DR OpenTargets; ENSG00000158863; -.
DR VEuPathDB; HostDB:ENSG00000158863; -.
DR eggNOG; KOG3695; Eukaryota.
DR GeneTree; ENSGT00950000182936; -.
DR HOGENOM; CLU_023718_0_0_1; -.
DR InParanoid; Q86V87; -.
DR OMA; CDHLIME; -.
DR OrthoDB; 266554at2759; -.
DR PhylomeDB; Q86V87; -.
DR TreeFam; TF313941; -.
DR PathwayCommons; Q86V87; -.
DR SignaLink; Q86V87; -.
DR BioGRID-ORCS; 64760; 16 hits in 1082 CRISPR screens.
DR GenomeRNAi; 64760; -.
DR Pharos; Q86V87; Tbio.
DR PRO; PR:Q86V87; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q86V87; protein.
DR Bgee; ENSG00000158863; Expressed in right lobe of thyroid gland and 147 other tissues.
DR ExpressionAtlas; Q86V87; baseline and differential.
DR Genevisible; Q86V87; HS.
DR InterPro; IPR019384; FHIP.
DR InterPro; IPR045669; FHIP_C.
DR InterPro; IPR045668; FHIP_KELAA_motif.
DR PANTHER; PTHR21705; PTHR21705; 1.
DR Pfam; PF19314; DUF5917; 1.
DR Pfam; PF19311; KELAA; 1.
DR Pfam; PF10257; RAI16-like; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..743
FT /note="FHF complex subunit HOOK interacting protein 2B"
FT /id="PRO_0000284645"
FT REGION 186..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 315
FT /note="T -> A (in dbSNP:rs35497596)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:15498874"
FT /id="VAR_054008"
FT VARIANT 667
FT /note="G -> R (in dbSNP:rs7822461)"
FT /id="VAR_054009"
FT CONFLICT 182
FT /note="R -> G (in Ref. 3; AAQ06676)"
FT /evidence="ECO:0000305"
FT CONFLICT 684
FT /note="L -> F (in Ref. 2; AAH12865/AAH13350)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 743 AA; 82340 MW; 3AD149894AB08CF5 CRC64;
MLSRLGALLQ EAVGAREPSI DLLQAFVEHW KGITHYYIES TDESTPAKKT DIPWRLKQML
DILVYEEQQQ AAAGEAGPCL EYLLQHKILE TLCTLGKAEY PPGMRQQVFQ FFSKVLAQVQ
HPLLHYLSVH RPVQKLLRLG GTASGSVTEK EEVQFTTVLC SKIQQDPELL AYILEGKKIV
GRKKACGEPT ALPKDTTSHG DKDCSHDGAP ARPQLDGESC GAQALNSHMP AETEELDGGT
TESNLITSLL GLCQSKKSRV ALKAQENLLL LVSMASPAAA TYLVQSSACC PAIVRHLCQL
YRSMPVFLDP ADIATLEGIS WRLPSAPSDE ASFPGKEALA AFLGWFDYCD HLITEAHTVV
ADALAKAVAE NFFVETLQPQ LLHVSEQSIL TSTALLTAML RQLRSPALLR EAVAFLLGTD
RQPEAPGDNP HTLYAHLIGH CDHLSDEISI TTLRLFEELL QKPHEGIIHS LVLRNLEGRP
YVAWGSPEPE SYEDTLDLEE DPYFTDSFLD SGFQTPAKPR LAPATSYDGK TAVTEIVNSF
LCLVPEEAKT SAFLEETGYD TYVHDAYGLF QECSSRVASW GWPLTPTPLD PHEPERPFFE
GHFLRVLFDR MSRILDQPYS LNLQVTSVLS RLALFPHPHI HEYLLDPYIS LAPGCRSLFS
VLVRVIGDLM QRIQRVPQFP GKLLLVRKQL TGQAPGEQLD HQTLLQGVVV LEEFCKELAA
IAFVKFPPHD PRQNVSPAPE GQV
