FHL17_HUMAN
ID FHL17_HUMAN Reviewed; 183 AA.
AC Q9BXU8; Q6NT24; Q6NTE2;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Ferritin heavy polypeptide-like 17;
DE AltName: Full=Cancer/testis antigen 38;
DE Short=CT38;
GN Name=FTHL17;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=11279525; DOI=10.1038/86927;
RA Wang P.J., McCarrey J.R., Yang F., Page D.C.;
RT "An abundance of X-linked genes expressed in spermatogonia.";
RL Nat. Genet. 27:422-426(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY, AND IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.
RX PubMed=12704671; DOI=10.1002/ijc.11104;
RA Loriot A., Boon T., De Smet C.;
RT "Five new human cancer-germline genes identified among 12 genes expressed
RT in spermatogonia.";
RL Int. J. Cancer 105:371-376(2003).
CC -!- INTERACTION:
CC Q9BXU8; Q2KHT4-3: GSG1; NbExp=3; IntAct=EBI-12156897, EBI-12951679;
CC Q9BXU8; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-12156897, EBI-10171774;
CC Q9BXU8; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-12156897, EBI-22310682;
CC Q9BXU8; Q9UHX1-2: PUF60; NbExp=3; IntAct=EBI-12156897, EBI-11529177;
CC Q9BXU8; Q96K37: SLC35E1; NbExp=3; IntAct=EBI-12156897, EBI-720094;
CC Q9BXU8; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-12156897, EBI-11528917;
CC -!- TISSUE SPECIFICITY: Testis specific. Also expressed in several cancers.
CC {ECO:0000269|PubMed:12704671}.
CC -!- SIMILARITY: Belongs to the ferritin family. {ECO:0000305}.
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DR EMBL; AF285592; AAK31971.1; -; mRNA.
DR EMBL; BC069069; AAH69069.2; -; mRNA.
DR EMBL; BC069538; AAH69538.2; -; mRNA.
DR EMBL; BC100768; AAI00769.1; -; mRNA.
DR EMBL; BC100769; AAI00770.1; -; mRNA.
DR EMBL; BC100770; AAI00771.1; -; mRNA.
DR CCDS; CCDS14227.1; -.
DR RefSeq; NP_114100.1; NM_031894.2.
DR AlphaFoldDB; Q9BXU8; -.
DR SMR; Q9BXU8; -.
DR BioGRID; 119822; 8.
DR IntAct; Q9BXU8; 6.
DR STRING; 9606.ENSP00000368207; -.
DR BioMuta; FTHL17; -.
DR DMDM; 18202740; -.
DR MassIVE; Q9BXU8; -.
DR MaxQB; Q9BXU8; -.
DR PaxDb; Q9BXU8; -.
DR PeptideAtlas; Q9BXU8; -.
DR PRIDE; Q9BXU8; -.
DR ProteomicsDB; 79522; -.
DR Antibodypedia; 24719; 43 antibodies from 12 providers.
DR DNASU; 53940; -.
DR Ensembl; ENST00000359202.5; ENSP00000368207.2; ENSG00000132446.7.
DR GeneID; 53940; -.
DR KEGG; hsa:53940; -.
DR MANE-Select; ENST00000359202.5; ENSP00000368207.2; NM_031894.3; NP_114100.1.
DR UCSC; uc004dcl.1; human.
DR CTD; 53940; -.
DR DisGeNET; 53940; -.
DR GeneCards; FTHL17; -.
DR HGNC; HGNC:3987; FTHL17.
DR HPA; ENSG00000132446; Tissue enriched (testis).
DR MIM; 300308; gene.
DR neXtProt; NX_Q9BXU8; -.
DR OpenTargets; ENSG00000132446; -.
DR PharmGKB; PA28402; -.
DR VEuPathDB; HostDB:ENSG00000132446; -.
DR eggNOG; KOG2332; Eukaryota.
DR GeneTree; ENSGT00940000165498; -.
DR HOGENOM; CLU_065681_4_0_1; -.
DR InParanoid; Q9BXU8; -.
DR OMA; ECQGWES; -.
DR OrthoDB; 1249457at2759; -.
DR PhylomeDB; Q9BXU8; -.
DR TreeFam; TF313885; -.
DR PathwayCommons; Q9BXU8; -.
DR SignaLink; Q9BXU8; -.
DR BioGRID-ORCS; 53940; 9 hits in 686 CRISPR screens.
DR ChiTaRS; FTHL17; human.
DR GenomeRNAi; 53940; -.
DR Pharos; Q9BXU8; Tdark.
DR PRO; PR:Q9BXU8; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9BXU8; protein.
DR Bgee; ENSG00000132446; Expressed in right testis and 3 other tissues.
DR ExpressionAtlas; Q9BXU8; baseline and differential.
DR Genevisible; Q9BXU8; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0008199; F:ferric iron binding; IBA:GO_Central.
DR GO; GO:0008198; F:ferrous iron binding; IBA:GO_Central.
DR GO; GO:0006880; P:intracellular sequestering of iron ion; IBA:GO_Central.
DR GO; GO:0006826; P:iron ion transport; IEA:InterPro.
DR Gene3D; 1.20.1260.10; -; 1.
DR InterPro; IPR001519; Ferritin.
DR InterPro; IPR012347; Ferritin-like.
DR InterPro; IPR009040; Ferritin-like_diiron.
DR InterPro; IPR009078; Ferritin-like_SF.
DR InterPro; IPR014034; Ferritin_CS.
DR InterPro; IPR008331; Ferritin_DPS_dom.
DR PANTHER; PTHR11431; PTHR11431; 1.
DR Pfam; PF00210; Ferritin; 1.
DR SUPFAM; SSF47240; SSF47240; 1.
DR PROSITE; PS00204; FERRITIN_2; 1.
DR PROSITE; PS50905; FERRITIN_LIKE; 1.
PE 1: Evidence at protein level;
KW Iron; Iron storage; Metal-binding; Reference proteome.
FT CHAIN 1..183
FT /note="Ferritin heavy polypeptide-like 17"
FT /id="PRO_0000201068"
FT DOMAIN 11..160
FT /note="Ferritin-like diiron"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00085"
FT BINDING 28
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00085"
FT BINDING 66
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00085"
FT BINDING 108
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00085"
FT BINDING 142
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00085"
FT VARIANT 120
FT /note="Q -> H (in dbSNP:rs16989319)"
FT /id="VAR_033929"
FT VARIANT 138
FT /note="Y -> H (in dbSNP:rs17340519)"
FT /id="VAR_049060"
SQ SEQUENCE 183 AA; 21142 MW; 7DA7DCEDDBE82583 CRC64;
MATAQPSQVR QKYDTNCDAA INSHITLELY TSYLYLSMAF YFNRDDVALE NFFRYFLRLS
DDKMEHAQKL MRLQNLRGGH ICLHDIRKPE CQGWESGLVA MESAFHLEKN VNQSLLDLYQ
LAVEKGDPQL CHFLESHYLH EQVKTIKELG GYVSNLRKIC SPEAGLAEYL FDKLTLGGRV
KET
