FHL17_MOUSE
ID FHL17_MOUSE Reviewed; 176 AA.
AC Q99MX2; L7MU38;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2013, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Ferritin heavy polypeptide-like 17;
GN Name=Fthl17;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=11279525; DOI=10.1038/86927;
RA Wang P.J., McCarrey J.R., Yang F., Page D.C.;
RT "An abundance of X-linked genes expressed in spermatogonia.";
RL Nat. Genet. 27:422-426(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- TISSUE SPECIFICITY: Testis specific.
CC -!- SIMILARITY: Belongs to the ferritin family. {ECO:0000305}.
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DR EMBL; AF285569; AAK31948.1; -; mRNA.
DR EMBL; AL806531; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS30003.1; -.
DR RefSeq; NP_112551.2; NM_031261.2.
DR AlphaFoldDB; Q99MX2; -.
DR SMR; Q99MX2; -.
DR STRING; 10090.ENSMUSP00000094254; -.
DR PaxDb; Q99MX2; -.
DR PRIDE; Q99MX2; -.
DR DNASU; 83457; -.
DR Ensembl; ENSMUST00000096509; ENSMUSP00000094254; ENSMUSG00000071815.
DR GeneID; 83457; -.
DR KEGG; mmu:83457; -.
DR UCSC; uc009spm.1; mouse.
DR CTD; 83457; -.
DR MGI; MGI:1933180; Fthl17.
DR VEuPathDB; HostDB:ENSMUSG00000071815; -.
DR eggNOG; KOG2332; Eukaryota.
DR GeneTree; ENSGT00950000182841; -.
DR HOGENOM; CLU_065681_4_0_1; -.
DR InParanoid; Q99MX2; -.
DR OMA; PTHAMES; -.
DR OrthoDB; 1249457at2759; -.
DR PhylomeDB; Q99MX2; -.
DR BioGRID-ORCS; 83457; 1 hit in 37 CRISPR screens.
DR PRO; PR:Q99MX2; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q99MX2; protein.
DR Bgee; ENSMUSG00000071815; Expressed in morula and 1 other tissue.
DR Genevisible; Q99MX2; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0008199; F:ferric iron binding; IBA:GO_Central.
DR GO; GO:0008198; F:ferrous iron binding; IBA:GO_Central.
DR GO; GO:0006880; P:intracellular sequestering of iron ion; IBA:GO_Central.
DR GO; GO:0006826; P:iron ion transport; IEA:InterPro.
DR Gene3D; 1.20.1260.10; -; 1.
DR InterPro; IPR001519; Ferritin.
DR InterPro; IPR012347; Ferritin-like.
DR InterPro; IPR009040; Ferritin-like_diiron.
DR InterPro; IPR009078; Ferritin-like_SF.
DR InterPro; IPR014034; Ferritin_CS.
DR InterPro; IPR008331; Ferritin_DPS_dom.
DR PANTHER; PTHR11431; PTHR11431; 1.
DR Pfam; PF00210; Ferritin; 1.
DR SUPFAM; SSF47240; SSF47240; 1.
DR PROSITE; PS00204; FERRITIN_2; 1.
DR PROSITE; PS50905; FERRITIN_LIKE; 1.
PE 2: Evidence at transcript level;
KW Iron; Iron storage; Metal-binding; Reference proteome.
FT CHAIN 1..176
FT /note="Ferritin heavy polypeptide-like 17"
FT /id="PRO_0000201069"
FT DOMAIN 10..159
FT /note="Ferritin-like diiron"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00085"
FT BINDING 27
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00085"
FT BINDING 107
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00085"
FT BINDING 141
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00085"
FT CONFLICT 80
FT /note="S -> I (in Ref. 1; AAK31948)"
FT /evidence="ECO:0000305"
FT CONFLICT 84
FT /note="G -> D (in Ref. 1; AAK31948)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 176 AA; 20491 MW; 590A4D44F063324C CRC64;
MAEAPSRMQQ NYDWQCEDAI NTHIQLCLYA SYEYMSMAVY FDRDDVAQEN FKRFFLTKSH
NCQTSAEMFM HLQNKRGGCS SLQGIARPER DSWHGGFQAM ECAFHMEMLI NQSLLNMHEV
AKEKGDPHLC HFLEQNCLDQ QVDILKEMSG YLTNLRQMGA VEHNLAEYLF DKLSLS
