FHL1_SCHPO
ID FHL1_SCHPO Reviewed; 743 AA.
AC O14270; Q9P7F6;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2002, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Fork head transcription factor 1;
GN Name=fhl1; ORFNames=SPAC1142.08, SPAC8C9.01;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION.
RX PubMed=15777722; DOI=10.1016/j.gene.2004.12.043;
RA Szilagyi Z., Batta G., Enczi K., Sipiczki M.;
RT "Characterisation of two novel fork-head gene homologues of
RT Schizosaccharomyces pombe: their involvement in cell cycle and sexual
RT differentiation.";
RL Gene 348:101-109(2005).
CC -!- FUNCTION: Acts as a transcriptional activator with a role in the
CC regulation of mitosis. Required for the correct timing, positioning and
CC contraction of the division septum. {ECO:0000269|PubMed:15777722}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329670; CAB77015.1; -; Genomic_DNA.
DR PIR; T39138; T39138.
DR RefSeq; NP_594272.1; NM_001019695.2.
DR AlphaFoldDB; O14270; -.
DR BioGRID; 278051; 85.
DR STRING; 4896.SPAC1142.08.1; -.
DR iPTMnet; O14270; -.
DR MaxQB; O14270; -.
DR PaxDb; O14270; -.
DR PRIDE; O14270; -.
DR EnsemblFungi; SPAC1142.08.1; SPAC1142.08.1:pep; SPAC1142.08.
DR GeneID; 2541552; -.
DR KEGG; spo:SPAC1142.08; -.
DR PomBase; SPAC1142.08; fhl1.
DR VEuPathDB; FungiDB:SPAC1142.08; -.
DR eggNOG; KOG2294; Eukaryota.
DR HOGENOM; CLU_373910_0_0_1; -.
DR InParanoid; O14270; -.
DR OMA; DICEWIS; -.
DR PhylomeDB; O14270; -.
DR PRO; PR:O14270; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; NAS:PomBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISM:PomBase.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProt.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProt.
DR GO; GO:0060962; P:regulation of ribosomal protein gene transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR CDD; cd00060; FHA; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR045178; Fhl1/FHA1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR21712; PTHR21712; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF49879; SSF49879; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 3: Inferred from homology;
KW Activator; Cell cycle; Cell division; DNA-binding; Mitosis; Nucleus;
KW Reference proteome; Septation; Transcription; Transcription regulation.
FT CHAIN 1..743
FT /note="Fork head transcription factor 1"
FT /id="PRO_0000091900"
FT DOMAIN 39..94
FT /note="FHA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT DNA_BIND 291..385
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 214..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 743 AA; 81128 MW; 2FD0FEAFDCFFA0DB CRC64;
MPVAEIKNAT QQPSSTNRVQ AYAKLEFEKF SFFVQTLQVT MGRKASNSSD CDVHLGDTKA
ISRQHAKIFY SFPNQRFEIS VMGKNGAFVD GEFVERGKSV PLRSGTRVQI GQISFSFLLP
EGSEEDGHLK ETGITPLSLQ QGKIAYSDEF GGKPTGSFHT VTSNQEKDLL FSHIKHESDL
PLGLSPADTN ISNATSIIEH PDAANAHTLA SLNQPPKHLT VSPSSIQRLS PQPYVRPTSD
ERPIETDSSV SAPKVANHDE ELKQGKSTSP SDTVLHPDLN GSPDTGDATQ KPNLSYANLI
ARTLIANPNK KMTLGDICEW IANNWSYYRH QPPAWHNSIR HNLSLNKAFI RIPRRQNEPG
KGSFWMLDPS YIDQFEGNFF RRTKKPTPSA TPAAHPDTAR ENELAAIQTK GISAGKTEQL
NPQKETSRSK THTSRGENVE DRPQSLLQNG IQPIIMRDGK LALNPEFFKN ANGEQQAPNE
QAVQAISLLQ QHINKQLGPA AANNPEQATA IANALAVALA QKLQKQQTQM QGPQQVQQQA
KRRKAYTSQQ LNPAPTAMPH PNITSPSPSI SVTQRPAVNV GPPPYVRPSA PSKLPDTRQS
IGDPLPPGAM ANVSAGPSSV RSSSYNSTAS ESKSEITSHQ NLHTIPINKP FTSDRPLYSS
PNDTLERVET GNQGQRMNSI GNASSFSKRD IMENENGSFD TNAKNGNNVD DSSSVRGMNL
PSNSSDALRG VKRPLDETSS SYT
