ID   FHL3_BOVIN              Reviewed;         280 AA.
AC   Q3ZBI6;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Four and a half LIM domains protein 3;
DE            Short=FHL-3;
GN   Name=FHL3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Recruited by SOX15 to FOXK1 promoters where it acts as a
CC       transcriptional coactivator of FOXK1. {ECO:0000250|UniProtKB:Q9R059}.
CC   -!- SUBUNIT: Interacts with SOX15; the interaction recruits FHL3 to FOXK1
CC       promoters where it acts as a transcriptional coactivator of FOXK1.
CC       {ECO:0000250|UniProtKB:Q9R059}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9R059}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9R059}.
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DR   EMBL; BC103276; AAI03277.1; -; mRNA.
DR   RefSeq; NP_001029395.1; NM_001034223.2.
DR   RefSeq; XP_015321413.1; XM_015465927.1.
DR   AlphaFoldDB; Q3ZBI6; -.
DR   SMR; Q3ZBI6; -.
DR   STRING; 9913.ENSBTAP00000009604; -.
DR   PaxDb; Q3ZBI6; -.
DR   Ensembl; ENSBTAT00000009604; ENSBTAP00000009604; ENSBTAG00000007300.
DR   GeneID; 504795; -.
DR   KEGG; bta:504795; -.
DR   CTD; 2275; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007300; -.
DR   VGNC; VGNC:29001; FHL3.
DR   eggNOG; KOG1704; Eukaryota.
DR   GeneTree; ENSGT00950000183028; -.
DR   HOGENOM; CLU_001357_2_0_1; -.
DR   InParanoid; Q3ZBI6; -.
DR   OMA; RILCRDC; -.
DR   OrthoDB; 642235at2759; -.
DR   TreeFam; TF314113; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000007300; Expressed in laryngeal cartilage and 104 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001725; C:stress fiber; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR   InterPro; IPR037987; FHL2/3/5.
DR   InterPro; IPR001781; Znf_LIM.
DR   PANTHER; PTHR24205; PTHR24205; 1.
DR   Pfam; PF00412; LIM; 4.
DR   SMART; SM00132; LIM; 4.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 4.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 4.
PE   2: Evidence at transcript level;
KW   Acetylation; Activator; Cytoplasm; LIM domain; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q13643"
FT   CHAIN           2..280
FT                   /note="Four and a half LIM domains protein 3"
FT                   /id="PRO_0000284661"
FT   DOMAIN          40..92
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          101..153
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          162..212
FT                   /note="LIM zinc-binding 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          221..275
FT                   /note="LIM zinc-binding 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   ZN_FING         7..31
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q13643"
FT   MOD_RES         157
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9R059"
FT   MOD_RES         235
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9R059"
SQ   SEQUENCE   280 AA;  31182 MW;  CD125F5352E77B85 CRC64;
     MSEAFDCAKC SESLYGRKYI QTDDGPYCVP CYDNTFANTC AECQQLIGHD SRELFYEDRH
     FHEGCFRCCR CQRSLADEPF TCQDSELLCN DCYCSAFSSQ CSACGETVMP GSRKLEYGGQ
     TWHEHCFLCS GCEQPLGSRS FVPDKGAHYC VPCYENKFAP RCARCSKTLT QGGVTYRDQP
     WHRECLVCTG CQTPLAGQQF TSREDDPYCV TCFGELFAPK CSSCKRPITG LGGGKYVSFE
     DRHWHHSCFS CARCSTSLVG QGFVPDGDQV LCQGCSQAGP