FHL3_BOVIN
ID FHL3_BOVIN Reviewed; 280 AA.
AC Q3ZBI6;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Four and a half LIM domains protein 3;
DE Short=FHL-3;
GN Name=FHL3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Heart ventricle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Recruited by SOX15 to FOXK1 promoters where it acts as a
CC transcriptional coactivator of FOXK1. {ECO:0000250|UniProtKB:Q9R059}.
CC -!- SUBUNIT: Interacts with SOX15; the interaction recruits FHL3 to FOXK1
CC promoters where it acts as a transcriptional coactivator of FOXK1.
CC {ECO:0000250|UniProtKB:Q9R059}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9R059}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9R059}.
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DR EMBL; BC103276; AAI03277.1; -; mRNA.
DR RefSeq; NP_001029395.1; NM_001034223.2.
DR RefSeq; XP_015321413.1; XM_015465927.1.
DR AlphaFoldDB; Q3ZBI6; -.
DR SMR; Q3ZBI6; -.
DR STRING; 9913.ENSBTAP00000009604; -.
DR PaxDb; Q3ZBI6; -.
DR Ensembl; ENSBTAT00000009604; ENSBTAP00000009604; ENSBTAG00000007300.
DR GeneID; 504795; -.
DR KEGG; bta:504795; -.
DR CTD; 2275; -.
DR VEuPathDB; HostDB:ENSBTAG00000007300; -.
DR VGNC; VGNC:29001; FHL3.
DR eggNOG; KOG1704; Eukaryota.
DR GeneTree; ENSGT00950000183028; -.
DR HOGENOM; CLU_001357_2_0_1; -.
DR InParanoid; Q3ZBI6; -.
DR OMA; RILCRDC; -.
DR OrthoDB; 642235at2759; -.
DR TreeFam; TF314113; -.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000007300; Expressed in laryngeal cartilage and 104 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001725; C:stress fiber; IBA:GO_Central.
DR GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR InterPro; IPR037987; FHL2/3/5.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24205; PTHR24205; 1.
DR Pfam; PF00412; LIM; 4.
DR SMART; SM00132; LIM; 4.
DR PROSITE; PS00478; LIM_DOMAIN_1; 4.
DR PROSITE; PS50023; LIM_DOMAIN_2; 4.
PE 2: Evidence at transcript level;
KW Acetylation; Activator; Cytoplasm; LIM domain; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q13643"
FT CHAIN 2..280
FT /note="Four and a half LIM domains protein 3"
FT /id="PRO_0000284661"
FT DOMAIN 40..92
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 101..153
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 162..212
FT /note="LIM zinc-binding 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 221..275
FT /note="LIM zinc-binding 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT ZN_FING 7..31
FT /note="C4-type"
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:Q13643"
FT MOD_RES 157
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9R059"
FT MOD_RES 235
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9R059"
SQ SEQUENCE 280 AA; 31182 MW; CD125F5352E77B85 CRC64;
MSEAFDCAKC SESLYGRKYI QTDDGPYCVP CYDNTFANTC AECQQLIGHD SRELFYEDRH
FHEGCFRCCR CQRSLADEPF TCQDSELLCN DCYCSAFSSQ CSACGETVMP GSRKLEYGGQ
TWHEHCFLCS GCEQPLGSRS FVPDKGAHYC VPCYENKFAP RCARCSKTLT QGGVTYRDQP
WHRECLVCTG CQTPLAGQQF TSREDDPYCV TCFGELFAPK CSSCKRPITG LGGGKYVSFE
DRHWHHSCFS CARCSTSLVG QGFVPDGDQV LCQGCSQAGP