FHL3_HUMAN
ID FHL3_HUMAN Reviewed; 280 AA.
AC Q13643; D3DPT6; Q6I9T0; Q9BVA2;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 4.
DT 03-AUG-2022, entry version 188.
DE RecName: Full=Four and a half LIM domains protein 3;
DE Short=FHL-3;
DE AltName: Full=Skeletal muscle LIM-protein 2;
DE Short=SLIM-2;
GN Name=FHL3; Synonyms=SLIM2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Skeletal muscle;
RX PubMed=10049693; DOI=10.1006/bbrc.1999.0179;
RA Morgan M.J., Madgwick A.J.A.;
RT "The LIM proteins FHL1 and FHL3 are expressed differently in skeletal
RT muscle.";
RL Biochem. Biophys. Res. Commun. 255:245-250(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA] OF 16-280.
RC TISSUE=Skeletal muscle;
RX PubMed=8753811; DOI=10.1006/bbrc.1996.1222;
RA Morgan M.J., Madgwick A.J.A.;
RT "Slim defines a novel family of LIM-proteins expressed in skeletal
RT muscle.";
RL Biochem. Biophys. Res. Commun. 225:632-638(1996).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [12]
RP STRUCTURE BY NMR OF 98-218 IN COMPLEX WITH ZINC IONS.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of LIM domains from human skeletal muscle LIM-protein
RT 2.";
RL Submitted (AUG-2005) to the PDB data bank.
CC -!- FUNCTION: Recruited by SOX15 to FOXK1 promoters where it acts as a
CC transcriptional coactivator of FOXK1. {ECO:0000250|UniProtKB:Q9R059}.
CC -!- SUBUNIT: Interacts with SOX15; the interaction recruits FHL3 to FOXK1
CC promoters where it acts as a transcriptional coactivator of FOXK1.
CC {ECO:0000250|UniProtKB:Q9R059}.
CC -!- INTERACTION:
CC Q13643; Q9NQ94: A1CF; NbExp=3; IntAct=EBI-741101, EBI-2809489;
CC Q13643; Q13444: ADAM15; NbExp=3; IntAct=EBI-741101, EBI-77818;
CC Q13643; Q13155: AIMP2; NbExp=13; IntAct=EBI-741101, EBI-745226;
CC Q13643; P02760: AMBP; NbExp=3; IntAct=EBI-741101, EBI-2115136;
CC Q13643; A0A0A0MQZ8: ANKHD1; NbExp=4; IntAct=EBI-741101, EBI-11531560;
CC Q13643; Q03989: ARID5A; NbExp=3; IntAct=EBI-741101, EBI-948603;
CC Q13643; Q6XD76: ASCL4; NbExp=3; IntAct=EBI-741101, EBI-10254793;
CC Q13643; Q9UMQ3: BARX2; NbExp=3; IntAct=EBI-741101, EBI-12053927;
CC Q13643; Q9BTE2: C16orf35; NbExp=3; IntAct=EBI-741101, EBI-10298364;
CC Q13643; Q6P1W5: C1orf94; NbExp=5; IntAct=EBI-741101, EBI-946029;
CC Q13643; Q5BN46: C9orf116; NbExp=3; IntAct=EBI-741101, EBI-10243636;
CC Q13643; Q5BN46-2: C9orf116; NbExp=3; IntAct=EBI-741101, EBI-12305735;
CC Q13643; Q9NQ75-2: CASS4; NbExp=5; IntAct=EBI-741101, EBI-12270182;
CC Q13643; Q9HC52: CBX8; NbExp=5; IntAct=EBI-741101, EBI-712912;
CC Q13643; E9PSE9: CCDC198; NbExp=3; IntAct=EBI-741101, EBI-11748295;
CC Q13643; Q9NVL8: CCDC198; NbExp=3; IntAct=EBI-741101, EBI-10238351;
CC Q13643; A0A0S2Z364: CLCN2; NbExp=3; IntAct=EBI-741101, EBI-16435545;
CC Q13643; Q8NE01: CNNM3; NbExp=9; IntAct=EBI-741101, EBI-741032;
CC Q13643; Q8NE01-3: CNNM3; NbExp=3; IntAct=EBI-741101, EBI-10269984;
CC Q13643; Q02930-3: CREB5; NbExp=3; IntAct=EBI-741101, EBI-10192698;
CC Q13643; Q6Q6R5-3: CRIP3; NbExp=3; IntAct=EBI-741101, EBI-12925520;
CC Q13643; P53672: CRYBA2; NbExp=3; IntAct=EBI-741101, EBI-750444;
CC Q13643; P09603: CSF1; NbExp=3; IntAct=EBI-741101, EBI-2872294;
CC Q13643; P56545: CTBP2; NbExp=4; IntAct=EBI-741101, EBI-741533;
CC Q13643; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-741101, EBI-3867333;
CC Q13643; A2VCK2: DCDC2B; NbExp=6; IntAct=EBI-741101, EBI-10173222;
CC Q13643; Q9Y2H0-1: DLGAP4; NbExp=3; IntAct=EBI-741101, EBI-12000556;
CC Q13643; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-741101, EBI-9679045;
CC Q13643; A0AVK6: E2F8; NbExp=3; IntAct=EBI-741101, EBI-7779316;
CC Q13643; Q6NXP0: EFCAB12; NbExp=3; IntAct=EBI-741101, EBI-10251535;
CC Q13643; Q5JZY3-3: EPHA10; NbExp=3; IntAct=EBI-741101, EBI-10244652;
CC Q13643; Q7L775: EPM2AIP1; NbExp=3; IntAct=EBI-741101, EBI-6255981;
CC Q13643; Q8N9I5: FADS6; NbExp=3; IntAct=EBI-741101, EBI-3943864;
CC Q13643; Q9BQ89: FAM110A; NbExp=3; IntAct=EBI-741101, EBI-1752811;
CC Q13643; Q9BYI3: FAM126A; NbExp=3; IntAct=EBI-741101, EBI-11065686;
CC Q13643; Q8WU58: FAM222B; NbExp=3; IntAct=EBI-741101, EBI-2807642;
CC Q13643; Q8NEG0: FAM71C; NbExp=3; IntAct=EBI-741101, EBI-752049;
CC Q13643; Q86YD7: FAM90A1; NbExp=7; IntAct=EBI-741101, EBI-6658203;
CC Q13643; Q96D16: FBXL18; NbExp=3; IntAct=EBI-741101, EBI-744419;
CC Q13643; P15408: FOSL2; NbExp=4; IntAct=EBI-741101, EBI-3893419;
CC Q13643; Q96NZ1: FOXN4; NbExp=4; IntAct=EBI-741101, EBI-11749712;
CC Q13643; P15976-2: GATA1; NbExp=4; IntAct=EBI-741101, EBI-9090198;
CC Q13643; P23769: GATA2; NbExp=5; IntAct=EBI-741101, EBI-2806671;
CC Q13643; O75603: GCM2; NbExp=11; IntAct=EBI-741101, EBI-10188645;
CC Q13643; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-741101, EBI-11978177;
CC Q13643; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-741101, EBI-11956675;
CC Q13643; Q86Z02: HIPK1; NbExp=4; IntAct=EBI-741101, EBI-692891;
CC Q13643; Q86Z02-4: HIPK1; NbExp=3; IntAct=EBI-741101, EBI-12025238;
CC Q13643; P49639: HOXA1; NbExp=3; IntAct=EBI-741101, EBI-740785;
CC Q13643; O75031: HSF2BP; NbExp=3; IntAct=EBI-741101, EBI-7116203;
CC Q13643; P42858: HTT; NbExp=9; IntAct=EBI-741101, EBI-466029;
CC Q13643; Q12891: HYAL2; NbExp=3; IntAct=EBI-741101, EBI-2806068;
CC Q13643; Q8IYA8: IHO1; NbExp=4; IntAct=EBI-741101, EBI-8638439;
CC Q13643; Q9UKT9: IKZF3; NbExp=4; IntAct=EBI-741101, EBI-747204;
CC Q13643; P18084: ITGB5; NbExp=5; IntAct=EBI-741101, EBI-1223434;
CC Q13643; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-741101, EBI-2556193;
CC Q13643; Q9ULH0-2: KIDINS220; NbExp=3; IntAct=EBI-741101, EBI-11046235;
CC Q13643; Q6UWL6: KIRREL2; NbExp=3; IntAct=EBI-741101, EBI-10254473;
CC Q13643; Q6UWL6-5: KIRREL2; NbExp=3; IntAct=EBI-741101, EBI-12794590;
CC Q13643; Q9Y4X4: KLF12; NbExp=3; IntAct=EBI-741101, EBI-750750;
CC Q13643; P57682: KLF3; NbExp=11; IntAct=EBI-741101, EBI-8472267;
CC Q13643; Q5T749: KPRP; NbExp=4; IntAct=EBI-741101, EBI-10981970;
CC Q13643; P59990: KRTAP12-1; NbExp=6; IntAct=EBI-741101, EBI-10210845;
CC Q13643; P59991: KRTAP12-2; NbExp=6; IntAct=EBI-741101, EBI-10176379;
CC Q13643; Q96EK9: KTI12; NbExp=3; IntAct=EBI-741101, EBI-7951092;
CC Q13643; Q9NRM7: LATS2; NbExp=4; IntAct=EBI-741101, EBI-3506895;
CC Q13643; P01229: LHB; NbExp=3; IntAct=EBI-741101, EBI-11659791;
CC Q13643; P25791: LMO2; NbExp=3; IntAct=EBI-741101, EBI-739696;
CC Q13643; P61968: LMO4; NbExp=3; IntAct=EBI-741101, EBI-2798728;
CC Q13643; Q8N448: LNX2; NbExp=4; IntAct=EBI-741101, EBI-2340947;
CC Q13643; P50281: MMP14; NbExp=3; IntAct=EBI-741101, EBI-992788;
CC Q13643; Q9HC36: MRM3; NbExp=8; IntAct=EBI-741101, EBI-1045440;
CC Q13643; Q9P0M9: MRPL27; NbExp=6; IntAct=EBI-741101, EBI-5325236;
CC Q13643; Q96E11: MRRF; NbExp=3; IntAct=EBI-741101, EBI-2855755;
CC Q13643; Q8IXL7-2: MSRB3; NbExp=3; IntAct=EBI-741101, EBI-10699187;
CC Q13643; A2RUH7: MYBPHL; NbExp=3; IntAct=EBI-741101, EBI-9088235;
CC Q13643; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-741101, EBI-5662487;
CC Q13643; Q86VE0: MYPOP; NbExp=3; IntAct=EBI-741101, EBI-2858213;
CC Q13643; O14561: NDUFAB1; NbExp=5; IntAct=EBI-741101, EBI-1246261;
CC Q13643; A8MYP8: ODF3B; NbExp=3; IntAct=EBI-741101, EBI-12010090;
CC Q13643; O15460-2: P4HA2; NbExp=3; IntAct=EBI-741101, EBI-10182841;
CC Q13643; Q86TB9: PATL1; NbExp=8; IntAct=EBI-741101, EBI-2562092;
CC Q13643; Q96BD5: PHF21A; NbExp=7; IntAct=EBI-741101, EBI-745085;
CC Q13643; Q99959-2: PKP2; NbExp=3; IntAct=EBI-741101, EBI-10987518;
CC Q13643; Q96PX9: PLEKHG4B; NbExp=4; IntAct=EBI-741101, EBI-11741362;
CC Q13643; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-741101, EBI-12000762;
CC Q13643; P0CG20: PRR35; NbExp=3; IntAct=EBI-741101, EBI-11986293;
CC Q13643; Q6MZQ0: PRR5L; NbExp=3; IntAct=EBI-741101, EBI-1567866;
CC Q13643; P29350: PTPN6; NbExp=3; IntAct=EBI-741101, EBI-78260;
CC Q13643; Q2TAL8: QRICH1; NbExp=6; IntAct=EBI-741101, EBI-2798044;
CC Q13643; O60216: RAD21; NbExp=4; IntAct=EBI-741101, EBI-80739;
CC Q13643; Q9NYN1: RASL12; NbExp=3; IntAct=EBI-741101, EBI-12917066;
CC Q13643; P48380: RFX3; NbExp=4; IntAct=EBI-741101, EBI-742557;
CC Q13643; Q8TAI7: RHEBL1; NbExp=3; IntAct=EBI-741101, EBI-746555;
CC Q13643; Q9UHP6: RSPH14; NbExp=3; IntAct=EBI-741101, EBI-748350;
CC Q13643; Q9UHR5: SAP30BP; NbExp=6; IntAct=EBI-741101, EBI-751683;
CC Q13643; Q8IYX7: SAXO1; NbExp=9; IntAct=EBI-741101, EBI-3957636;
CC Q13643; Q86WG5: SBF2; NbExp=3; IntAct=EBI-741101, EBI-2683289;
CC Q13643; O00560: SDCBP; NbExp=3; IntAct=EBI-741101, EBI-727004;
CC Q13643; Q5VZ18: SHE; NbExp=3; IntAct=EBI-741101, EBI-3956977;
CC Q13643; Q8ND83: SLAIN1; NbExp=6; IntAct=EBI-741101, EBI-10269374;
CC Q13643; Q96AG3: SLC25A46; NbExp=6; IntAct=EBI-741101, EBI-10281975;
CC Q13643; Q8N4M1: SLC44A3; NbExp=3; IntAct=EBI-741101, EBI-10265585;
CC Q13643; O95391: SLU7; NbExp=3; IntAct=EBI-741101, EBI-750559;
CC Q13643; P14678-2: SNRPB; NbExp=3; IntAct=EBI-741101, EBI-372475;
CC Q13643; P09234: SNRPC; NbExp=3; IntAct=EBI-741101, EBI-766589;
CC Q13643; P62308: SNRPG; NbExp=6; IntAct=EBI-741101, EBI-624585;
CC Q13643; Q9NU19: TBC1D22B; NbExp=3; IntAct=EBI-741101, EBI-8787464;
CC Q13643; Q9BT49: THAP7; NbExp=3; IntAct=EBI-741101, EBI-741350;
CC Q13643; Q9P2T0: THEG; NbExp=4; IntAct=EBI-741101, EBI-751020;
CC Q13643; Q08117-2: TLE5; NbExp=4; IntAct=EBI-741101, EBI-11741437;
CC Q13643; Q6UXF1: TMEM108; NbExp=3; IntAct=EBI-741101, EBI-7100456;
CC Q13643; P62328: TMSB4X; NbExp=3; IntAct=EBI-741101, EBI-712598;
CC Q13643; Q96JJ7: TMX3; NbExp=3; IntAct=EBI-741101, EBI-2514069;
CC Q13643; G5E9N2: TRO; NbExp=3; IntAct=EBI-741101, EBI-10178070;
CC Q13643; Q3SY00: TSGA10IP; NbExp=5; IntAct=EBI-741101, EBI-10241197;
CC Q13643; Q6ZVT0: TTLL10; NbExp=3; IntAct=EBI-741101, EBI-7844656;
CC Q13643; Q6ZVT0-3: TTLL10; NbExp=3; IntAct=EBI-741101, EBI-11979997;
CC Q13643; Q6PEY2: TUBA3E; NbExp=3; IntAct=EBI-741101, EBI-2551023;
CC Q13643; P29597: TYK2; NbExp=6; IntAct=EBI-741101, EBI-1383454;
CC Q13643; Q8TAI1: TYMSOS; NbExp=3; IntAct=EBI-741101, EBI-742060;
CC Q13643; Q7Z7E8-2: UBE2Q1; NbExp=3; IntAct=EBI-741101, EBI-10258181;
CC Q13643; B2RUY7: VWC2L; NbExp=4; IntAct=EBI-741101, EBI-11747707;
CC Q13643; Q64LD2-2: WDR25; NbExp=3; IntAct=EBI-741101, EBI-12032042;
CC Q13643; Q8WYQ9: ZCCHC14; NbExp=3; IntAct=EBI-741101, EBI-3937908;
CC Q13643; P26651: ZFP36; NbExp=4; IntAct=EBI-741101, EBI-374248;
CC Q13643; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-741101, EBI-740727;
CC Q13643; Q96KM6: ZNF512B; NbExp=8; IntAct=EBI-741101, EBI-1049952;
CC Q13643; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-741101, EBI-6427977;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9R059}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9R059}.
CC -!- TISSUE SPECIFICITY: Expressed only in skeletal muscle.
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DR EMBL; U60116; AAC04466.2; -; mRNA.
DR EMBL; AK290641; BAF83330.1; -; mRNA.
DR EMBL; BT007052; AAP35701.1; -; mRNA.
DR EMBL; CR457425; CAG33706.1; -; mRNA.
DR EMBL; AL603790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471059; EAX07301.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX07302.1; -; Genomic_DNA.
DR EMBL; BC001351; AAH01351.1; -; mRNA.
DR EMBL; BC011697; AAH11697.1; -; mRNA.
DR CCDS; CCDS30678.1; -.
DR PIR; T09504; T09504.
DR RefSeq; NP_001230807.1; NM_001243878.1.
DR RefSeq; NP_004459.2; NM_004468.4.
DR PDB; 1WYH; NMR; -; A=101-159.
DR PDB; 2CUQ; NMR; -; A=152-218.
DR PDB; 2EHE; NMR; -; A=30-99.
DR PDBsum; 1WYH; -.
DR PDBsum; 2CUQ; -.
DR PDBsum; 2EHE; -.
DR AlphaFoldDB; Q13643; -.
DR SMR; Q13643; -.
DR BioGRID; 108566; 267.
DR CORUM; Q13643; -.
DR DIP; DIP-42030N; -.
DR IntAct; Q13643; 173.
DR MINT; Q13643; -.
DR STRING; 9606.ENSP00000362107; -.
DR GlyGen; Q13643; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q13643; -.
DR PhosphoSitePlus; Q13643; -.
DR BioMuta; FHL3; -.
DR DMDM; 209572768; -.
DR EPD; Q13643; -.
DR jPOST; Q13643; -.
DR MassIVE; Q13643; -.
DR MaxQB; Q13643; -.
DR PaxDb; Q13643; -.
DR PeptideAtlas; Q13643; -.
DR PRIDE; Q13643; -.
DR ProteomicsDB; 59647; -.
DR Antibodypedia; 31823; 178 antibodies from 32 providers.
DR DNASU; 2275; -.
DR Ensembl; ENST00000373016.4; ENSP00000362107.3; ENSG00000183386.10.
DR GeneID; 2275; -.
DR KEGG; hsa:2275; -.
DR MANE-Select; ENST00000373016.4; ENSP00000362107.3; NM_004468.5; NP_004459.2.
DR UCSC; uc001cck.4; human.
DR CTD; 2275; -.
DR DisGeNET; 2275; -.
DR GeneCards; FHL3; -.
DR HGNC; HGNC:3704; FHL3.
DR HPA; ENSG00000183386; Group enriched (skeletal muscle, tongue).
DR MIM; 602790; gene.
DR neXtProt; NX_Q13643; -.
DR OpenTargets; ENSG00000183386; -.
DR PharmGKB; PA28142; -.
DR VEuPathDB; HostDB:ENSG00000183386; -.
DR eggNOG; KOG1704; Eukaryota.
DR GeneTree; ENSGT00950000183028; -.
DR HOGENOM; CLU_001357_2_0_1; -.
DR InParanoid; Q13643; -.
DR OMA; RILCRDC; -.
DR OrthoDB; 642235at2759; -.
DR PhylomeDB; Q13643; -.
DR TreeFam; TF314113; -.
DR PathwayCommons; Q13643; -.
DR SignaLink; Q13643; -.
DR BioGRID-ORCS; 2275; 16 hits in 1093 CRISPR screens.
DR ChiTaRS; FHL3; human.
DR EvolutionaryTrace; Q13643; -.
DR GeneWiki; FHL3; -.
DR GenomeRNAi; 2275; -.
DR Pharos; Q13643; Tbio.
DR PRO; PR:Q13643; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q13643; protein.
DR Bgee; ENSG00000183386; Expressed in hindlimb stylopod muscle and 118 other tissues.
DR Genevisible; Q13643; HS.
DR GO; GO:0005925; C:focal adhesion; HDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001725; C:stress fiber; IBA:GO_Central.
DR GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0007517; P:muscle organ development; TAS:ProtInc.
DR InterPro; IPR037987; FHL2/3/5.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24205; PTHR24205; 1.
DR Pfam; PF00412; LIM; 4.
DR SMART; SM00132; LIM; 4.
DR PROSITE; PS00478; LIM_DOMAIN_1; 4.
DR PROSITE; PS50023; LIM_DOMAIN_2; 4.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Activator; Cytoplasm; LIM domain; Metal-binding;
KW Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22814378"
FT CHAIN 2..280
FT /note="Four and a half LIM domains protein 3"
FT /id="PRO_0000075740"
FT DOMAIN 40..92
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 101..153
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 162..212
FT /note="LIM zinc-binding 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 221..275
FT /note="LIM zinc-binding 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT ZN_FING 7..31
FT /note="C4-type"
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 157
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9R059"
FT MOD_RES 235
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9R059"
FT CONFLICT 82
FT /note="C -> R (in Ref. 1; AAC04466)"
FT /evidence="ECO:0000305"
FT CONFLICT 130
FT /note="S -> I (in Ref. 1; AAC04466)"
FT /evidence="ECO:0000305"
FT CONFLICT 140
FT /note="S -> P (in Ref. 1; AAC04466)"
FT /evidence="ECO:0000305"
FT CONFLICT 157
FT /note="K -> N (in Ref. 1; AAC04466)"
FT /evidence="ECO:0000305"
FT CONFLICT 166
FT /note="S -> T (in Ref. 1; AAC04466)"
FT /evidence="ECO:0000305"
FT CONFLICT 174
FT /note="V -> L (in Ref. 1; AAC04466)"
FT /evidence="ECO:0000305"
FT CONFLICT 179
FT /note="Q -> L (in Ref. 1; AAC04466)"
FT /evidence="ECO:0000305"
FT CONFLICT 183..184
FT /note="RE -> PK (in Ref. 1; AAC04466)"
FT /evidence="ECO:0000305"
FT CONFLICT 250..252
FT /note="SCA -> TCD (in Ref. 1; AAC04466)"
FT /evidence="ECO:0000305"
FT CONFLICT 252
FT /note="A -> D (in Ref. 4; CAG33706)"
FT /evidence="ECO:0000305"
FT CONFLICT 256
FT /note="T -> N (in Ref. 1; AAC04466)"
FT /evidence="ECO:0000305"
FT TURN 41..43
FT /evidence="ECO:0007829|PDB:2EHE"
FT TURN 63..65
FT /evidence="ECO:0007829|PDB:2EHE"
FT TURN 69..71
FT /evidence="ECO:0007829|PDB:2EHE"
FT STRAND 80..83
FT /evidence="ECO:0007829|PDB:2EHE"
FT STRAND 86..89
FT /evidence="ECO:0007829|PDB:2EHE"
FT TURN 90..92
FT /evidence="ECO:0007829|PDB:2EHE"
FT STRAND 102..104
FT /evidence="ECO:0007829|PDB:1WYH"
FT STRAND 110..112
FT /evidence="ECO:0007829|PDB:1WYH"
FT TURN 124..126
FT /evidence="ECO:0007829|PDB:1WYH"
FT TURN 130..132
FT /evidence="ECO:0007829|PDB:1WYH"
FT TURN 136..138
FT /evidence="ECO:0007829|PDB:1WYH"
FT STRAND 141..144
FT /evidence="ECO:0007829|PDB:1WYH"
FT STRAND 147..150
FT /evidence="ECO:0007829|PDB:1WYH"
FT HELIX 151..157
FT /evidence="ECO:0007829|PDB:1WYH"
FT TURN 163..165
FT /evidence="ECO:0007829|PDB:2CUQ"
FT STRAND 174..181
FT /evidence="ECO:0007829|PDB:2CUQ"
FT TURN 183..185
FT /evidence="ECO:0007829|PDB:2CUQ"
FT STRAND 189..191
FT /evidence="ECO:0007829|PDB:2CUQ"
FT STRAND 200..202
FT /evidence="ECO:0007829|PDB:2CUQ"
FT STRAND 204..209
FT /evidence="ECO:0007829|PDB:2CUQ"
FT HELIX 210..216
FT /evidence="ECO:0007829|PDB:2CUQ"
SQ SEQUENCE 280 AA; 31192 MW; D1A037C260370DFD CRC64;
MSESFDCAKC NESLYGRKYI QTDSGPYCVP CYDNTFANTC AECQQLIGHD SRELFYEDRH
FHEGCFRCCR CQRSLADEPF TCQDSELLCN DCYCSAFSSQ CSACGETVMP GSRKLEYGGQ
TWHEHCFLCS GCEQPLGSRS FVPDKGAHYC VPCYENKFAP RCARCSKTLT QGGVTYRDQP
WHRECLVCTG CQTPLAGQQF TSRDEDPYCV ACFGELFAPK CSSCKRPIVG LGGGKYVSFE
DRHWHHNCFS CARCSTSLVG QGFVPDGDQV LCQGCSQAGP
