ID   FHL5_BOVIN              Reviewed;         284 AA.
AC   Q2YDK0;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Four and a half LIM domains protein 5;
DE            Short=FHL-5;
GN   Name=FHL5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in the regulation of spermatogenesis.
CC       Stimulates CREM transcriptional activity in a phosphorylation-
CC       independent manner (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CREM (via the third LIM domain). Interacts (via
CC       second LIM domain) with SPAG8. {ECO:0000250|UniProtKB:Q9WTX7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Nuclei of round and
CC       elongated spermatids. {ECO:0000250}.
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DR   EMBL; BC110187; AAI10188.1; -; mRNA.
DR   RefSeq; NP_001069847.1; NM_001076379.2.
DR   RefSeq; XP_010806794.1; XM_010808492.2.
DR   AlphaFoldDB; Q2YDK0; -.
DR   SMR; Q2YDK0; -.
DR   STRING; 9913.ENSBTAP00000002359; -.
DR   PaxDb; Q2YDK0; -.
DR   PRIDE; Q2YDK0; -.
DR   Ensembl; ENSBTAT00000002359; ENSBTAP00000002359; ENSBTAG00000001803.
DR   Ensembl; ENSBTAT00000077613; ENSBTAP00000063278; ENSBTAG00000001803.
DR   Ensembl; ENSBTAT00000079068; ENSBTAP00000071380; ENSBTAG00000001803.
DR   GeneID; 615499; -.
DR   KEGG; bta:615499; -.
DR   CTD; 9457; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001803; -.
DR   VGNC; VGNC:29002; FHL5.
DR   eggNOG; KOG1704; Eukaryota.
DR   GeneTree; ENSGT00950000183028; -.
DR   HOGENOM; CLU_001357_2_0_1; -.
DR   InParanoid; Q2YDK0; -.
DR   OMA; ERCFNCA; -.
DR   OrthoDB; 642235at2759; -.
DR   TreeFam; TF314113; -.
DR   Proteomes; UP000009136; Chromosome 9.
DR   Bgee; ENSBTAG00000001803; Expressed in semen and 75 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd09428; LIM2_FHL5; 1.
DR   InterPro; IPR037987; FHL2/3/5.
DR   InterPro; IPR042947; FHL5_LIM2.
DR   InterPro; IPR001781; Znf_LIM.
DR   PANTHER; PTHR24205; PTHR24205; 1.
DR   Pfam; PF00412; LIM; 4.
DR   SMART; SM00132; LIM; 4.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 4.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 4.
PE   2: Evidence at transcript level;
KW   LIM domain; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..284
FT                   /note="Four and a half LIM domains protein 5"
FT                   /id="PRO_0000284660"
FT   DOMAIN          39..100
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          101..160
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          161..220
FT                   /note="LIM zinc-binding 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          223..283
FT                   /note="LIM zinc-binding 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   ZN_FING         8..32
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   284 AA;  32810 MW;  75B989C55D12CC6E CRC64;
     MTTPQFYCQY CMASLLGKKY VLKDDNPYCV SCYDRIFSNY CEECKEPIES GSKDLCYKGH
     HWHEGCFNCT KCNHSLVEKP FAAKDERLLC SECYSNECSS KCFHCKKTIM PGSRKMEFKG
     NYWHETCFVC EHCRQPIGTK PLISKESGNY CVPCFEKEFA HYCSFCKKVI TSGGITFRDQ
     PWHKECFLCS GCRKELCEEE FMSRDDYPFC LDCYNHLYAK KCAACTKPIT GLRGAKFICF
     QDRQWHSECF NCGKCSVSLV GEGFLTHNKE IFCRKCGSGV DTDI