FHL5_HUMAN
ID FHL5_HUMAN Reviewed; 284 AA.
AC Q5TD97; B2RBD1; E1P526; Q5TD98; Q8WW21; Q9NQU2;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Four and a half LIM domains protein 5;
DE Short=FHL-5;
DE AltName: Full=Activator of cAMP-responsive element modulator in testis;
DE Short=Activator of CREM in testis;
GN Name=FHL5; Synonyms=ACT;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-211, FUNCTION, SUBCELLULAR
RP LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=11327716; DOI=10.1006/bbrc.2001.4805;
RA Palermo I., Litrico L., Emmanuele G., Giuffrida V., Sassone-Corsi P.,
RA De Cesare D., Maria Fimia G., D'Agata R., Calogero A.E., Travali S.;
RT "Cloning and expression of activator of CREM in testis in human testicular
RT tissue.";
RL Biochem. Biophys. Res. Commun. 283:406-411(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-211.
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-211.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP STRUCTURE BY NMR OF 222-284 IN COMPLEX WITH ZINC IONS.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structures of the C-terminal LIM domain of human FHL5 protein.";
RL Submitted (NOV-2005) to the PDB data bank.
CC -!- FUNCTION: May be involved in the regulation of spermatogenesis.
CC Stimulates CREM transcriptional activity in a phosphorylation-
CC independent manner. {ECO:0000269|PubMed:11327716}.
CC -!- SUBUNIT: Interacts with CREM (via the third LIM domain). Interacts (via
CC second LIM domain) with SPAG8. {ECO:0000250|UniProtKB:Q9WTX7}.
CC -!- INTERACTION:
CC Q5TD97; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-750641, EBI-11096309;
CC Q5TD97; O43184-4: ADAM12; NbExp=3; IntAct=EBI-750641, EBI-12006944;
CC Q5TD97; Q6ZMM2: ADAMTSL5; NbExp=3; IntAct=EBI-750641, EBI-9075891;
CC Q5TD97; P21549: AGXT; NbExp=3; IntAct=EBI-750641, EBI-727098;
CC Q5TD97; Q3KP44: ANKRD55; NbExp=3; IntAct=EBI-750641, EBI-14493093;
CC Q5TD97; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-750641, EBI-11954519;
CC Q5TD97; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-750641, EBI-11524452;
CC Q5TD97; Q8N9N5-7: BANP; NbExp=3; IntAct=EBI-750641, EBI-16429296;
CC Q5TD97; Q96PG8: BBC3; NbExp=3; IntAct=EBI-750641, EBI-17289784;
CC Q5TD97; A8KA13: BCL6B; NbExp=3; IntAct=EBI-750641, EBI-10174813;
CC Q5TD97; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-750641, EBI-744545;
CC Q5TD97; Q86Y33-5: CDC20B; NbExp=3; IntAct=EBI-750641, EBI-11983537;
CC Q5TD97; P27918: CFP; NbExp=3; IntAct=EBI-750641, EBI-9038570;
CC Q5TD97; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-750641, EBI-741032;
CC Q5TD97; Q96A83-2: COL26A1; NbExp=3; IntAct=EBI-750641, EBI-21553822;
CC Q5TD97; P53672: CRYBA2; NbExp=3; IntAct=EBI-750641, EBI-750444;
CC Q5TD97; P53673: CRYBA4; NbExp=3; IntAct=EBI-750641, EBI-7519711;
CC Q5TD97; Q9UBR2: CTSZ; NbExp=3; IntAct=EBI-750641, EBI-8636823;
CC Q5TD97; A2VCK2: DCDC2B; NbExp=3; IntAct=EBI-750641, EBI-10173222;
CC Q5TD97; Q9Y2H0-1: DLGAP4; NbExp=3; IntAct=EBI-750641, EBI-12000556;
CC Q5TD97; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-750641, EBI-9679045;
CC Q5TD97; G5E9A7: DMWD; NbExp=3; IntAct=EBI-750641, EBI-10976677;
CC Q5TD97; O96015: DNAL4; NbExp=10; IntAct=EBI-750641, EBI-742362;
CC Q5TD97; Q86UW9: DTX2; NbExp=3; IntAct=EBI-750641, EBI-740376;
CC Q5TD97; Q7L5A3: FAM214B; NbExp=5; IntAct=EBI-750641, EBI-745689;
CC Q5TD97; Q8NEG0: FAM71C; NbExp=5; IntAct=EBI-750641, EBI-752049;
CC Q5TD97; O95363: FARS2; NbExp=3; IntAct=EBI-750641, EBI-2513774;
CC Q5TD97; A0PJY2: FEZF1; NbExp=3; IntAct=EBI-750641, EBI-11988727;
CC Q5TD97; Q13227: GPS2; NbExp=3; IntAct=EBI-750641, EBI-713355;
CC Q5TD97; P09211: GSTP1; NbExp=3; IntAct=EBI-750641, EBI-353467;
CC Q5TD97; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-750641, EBI-11956675;
CC Q5TD97; P08631-2: HCK; NbExp=3; IntAct=EBI-750641, EBI-9834454;
CC Q5TD97; Q7Z353: HDX; NbExp=3; IntAct=EBI-750641, EBI-1052734;
CC Q5TD97; Q9UBP5: HEY2; NbExp=3; IntAct=EBI-750641, EBI-750630;
CC Q5TD97; P49639: HOXA1; NbExp=3; IntAct=EBI-750641, EBI-740785;
CC Q5TD97; P17482: HOXB9; NbExp=3; IntAct=EBI-750641, EBI-745290;
CC Q5TD97; Q14005-2: IL16; NbExp=5; IntAct=EBI-750641, EBI-17178971;
CC Q5TD97; Q96PC2: IP6K3; NbExp=3; IntAct=EBI-750641, EBI-10990676;
CC Q5TD97; Q99706: KIR2DL4; NbExp=3; IntAct=EBI-750641, EBI-10294579;
CC Q5TD97; O14901: KLF11; NbExp=3; IntAct=EBI-750641, EBI-948266;
CC Q5TD97; P25791-3: LMO2; NbExp=3; IntAct=EBI-750641, EBI-11959475;
CC Q5TD97; Q15345: LRRC41; NbExp=3; IntAct=EBI-750641, EBI-721408;
CC Q5TD97; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-750641, EBI-746778;
CC Q5TD97; Q8IVT2: MISP; NbExp=3; IntAct=EBI-750641, EBI-2555085;
CC Q5TD97; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-750641, EBI-5662487;
CC Q5TD97; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-750641, EBI-11750983;
CC Q5TD97; Q9NQX5: NPDC1; NbExp=5; IntAct=EBI-750641, EBI-748927;
CC Q5TD97; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-750641, EBI-1210753;
CC Q5TD97; P32242: OTX1; NbExp=3; IntAct=EBI-750641, EBI-740446;
CC Q5TD97; Q13526: PIN1; NbExp=3; IntAct=EBI-750641, EBI-714158;
CC Q5TD97; Q9HB19: PLEKHA2; NbExp=3; IntAct=EBI-750641, EBI-4401947;
CC Q5TD97; Q494U1-3: PLEKHN1; NbExp=3; IntAct=EBI-750641, EBI-12014286;
CC Q5TD97; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-750641, EBI-2557469;
CC Q5TD97; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-750641, EBI-12000762;
CC Q5TD97; Q2TAL8: QRICH1; NbExp=3; IntAct=EBI-750641, EBI-2798044;
CC Q5TD97; Q9ULW5: RAB26; NbExp=3; IntAct=EBI-750641, EBI-958239;
CC Q5TD97; Q8TBN0: RAB3IL1; NbExp=3; IntAct=EBI-750641, EBI-743796;
CC Q5TD97; P63220: RPS21; NbExp=3; IntAct=EBI-750641, EBI-714051;
CC Q5TD97; Q8IYX7: SAXO1; NbExp=3; IntAct=EBI-750641, EBI-3957636;
CC Q5TD97; Q9BWG6: SCNM1; NbExp=6; IntAct=EBI-750641, EBI-748391;
CC Q5TD97; O00560: SDCBP; NbExp=3; IntAct=EBI-750641, EBI-727004;
CC Q5TD97; O94979-2: SEC31A; NbExp=3; IntAct=EBI-750641, EBI-17482477;
CC Q5TD97; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-750641, EBI-11955083;
CC Q5TD97; O75093: SLIT1; NbExp=3; IntAct=EBI-750641, EBI-947791;
CC Q5TD97; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-750641, EBI-5235340;
CC Q5TD97; O43609: SPRY1; NbExp=5; IntAct=EBI-750641, EBI-3866665;
CC Q5TD97; O75896: TUSC2; NbExp=3; IntAct=EBI-750641, EBI-1052725;
CC Q5TD97; Q99757: TXN2; NbExp=3; IntAct=EBI-750641, EBI-2932492;
CC Q5TD97; Q05516: ZBTB16; NbExp=3; IntAct=EBI-750641, EBI-711925;
CC Q5TD97; Q15973: ZNF124; NbExp=3; IntAct=EBI-750641, EBI-2555767;
CC Q5TD97; P52739-2: ZNF131; NbExp=4; IntAct=EBI-750641, EBI-10213055;
CC Q5TD97; P17027: ZNF23; NbExp=3; IntAct=EBI-750641, EBI-5657766;
CC Q5TD97; P15622-3: ZNF250; NbExp=5; IntAct=EBI-750641, EBI-10177272;
CC Q5TD97; Q9BRH9: ZNF251; NbExp=3; IntAct=EBI-750641, EBI-7254491;
CC Q5TD97; Q9H9D4: ZNF408; NbExp=3; IntAct=EBI-750641, EBI-347633;
CC Q5TD97; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-750641, EBI-740727;
CC Q5TD97; Q8IYI8: ZNF440; NbExp=3; IntAct=EBI-750641, EBI-726439;
CC Q5TD97; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-750641, EBI-10273713;
CC Q5TD97; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-750641, EBI-745520;
CC Q5TD97; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-750641, EBI-6427977;
CC Q5TD97; Q6PF04: ZNF613; NbExp=3; IntAct=EBI-750641, EBI-12062855;
CC Q5TD97; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-750641, EBI-16429014;
CC Q5TD97; A0A0S2Z6P0: ZNF688; NbExp=3; IntAct=EBI-750641, EBI-16429989;
CC Q5TD97; Q96H86: ZNF764; NbExp=3; IntAct=EBI-750641, EBI-745775;
CC Q5TD97; Q5HY98: ZNF766; NbExp=3; IntAct=EBI-750641, EBI-2686489;
CC Q5TD97; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-750641, EBI-10240849;
CC Q5TD97; O43257: ZNHIT1; NbExp=3; IntAct=EBI-750641, EBI-347522;
CC Q5TD97; P09022: Hoxa1; Xeno; NbExp=3; IntAct=EBI-750641, EBI-3957603;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11327716}.
CC Note=Nuclei of round and elongated spermatids.
CC -!- TISSUE SPECIFICITY: Testis-specific (at protein level).
CC {ECO:0000269|PubMed:11327716}.
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DR EMBL; AF278541; AAF85978.1; -; mRNA.
DR EMBL; AK057611; BAG51940.1; -; mRNA.
DR EMBL; AK223539; BAD97259.1; -; mRNA.
DR EMBL; AK314608; BAG37178.1; -; mRNA.
DR EMBL; AL132776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471051; EAW48503.1; -; Genomic_DNA.
DR EMBL; CH471051; EAW48504.1; -; Genomic_DNA.
DR EMBL; CH471051; EAW48505.1; -; Genomic_DNA.
DR EMBL; BC021723; AAH21723.1; -; mRNA.
DR EMBL; BC029490; AAH29490.1; -; mRNA.
DR CCDS; CCDS5035.1; -.
DR PIR; JC7686; JC7686.
DR RefSeq; NP_001164278.1; NM_001170807.2.
DR RefSeq; NP_001309395.1; NM_001322466.1.
DR RefSeq; NP_001309396.1; NM_001322467.1.
DR RefSeq; NP_065228.4; NM_020482.5.
DR PDB; 1X68; NMR; -; A=222-284.
DR PDBsum; 1X68; -.
DR AlphaFoldDB; Q5TD97; -.
DR SMR; Q5TD97; -.
DR BioGRID; 114846; 101.
DR CORUM; Q5TD97; -.
DR IntAct; Q5TD97; 97.
DR MINT; Q5TD97; -.
DR STRING; 9606.ENSP00000326022; -.
DR iPTMnet; Q5TD97; -.
DR PhosphoSitePlus; Q5TD97; -.
DR BioMuta; FHL5; -.
DR DMDM; 68565455; -.
DR MassIVE; Q5TD97; -.
DR PaxDb; Q5TD97; -.
DR PeptideAtlas; Q5TD97; -.
DR PRIDE; Q5TD97; -.
DR ProteomicsDB; 65008; -.
DR Antibodypedia; 31954; 165 antibodies from 23 providers.
DR DNASU; 9457; -.
DR Ensembl; ENST00000326771.2; ENSP00000326022.2; ENSG00000112214.11.
DR Ensembl; ENST00000450218.6; ENSP00000396390.2; ENSG00000112214.11.
DR Ensembl; ENST00000541107.5; ENSP00000442357.1; ENSG00000112214.11.
DR GeneID; 9457; -.
DR KEGG; hsa:9457; -.
DR MANE-Select; ENST00000450218.6; ENSP00000396390.2; NM_001322466.2; NP_001309395.1.
DR UCSC; uc003pos.3; human.
DR CTD; 9457; -.
DR DisGeNET; 9457; -.
DR GeneCards; FHL5; -.
DR HGNC; HGNC:17371; FHL5.
DR HPA; ENSG00000112214; Tissue enhanced (testis).
DR MIM; 605126; gene.
DR neXtProt; NX_Q5TD97; -.
DR OpenTargets; ENSG00000112214; -.
DR PharmGKB; PA134971720; -.
DR VEuPathDB; HostDB:ENSG00000112214; -.
DR eggNOG; KOG1704; Eukaryota.
DR GeneTree; ENSGT00950000183028; -.
DR HOGENOM; CLU_001357_2_0_1; -.
DR InParanoid; Q5TD97; -.
DR OMA; ERCFNCA; -.
DR OrthoDB; 642235at2759; -.
DR PhylomeDB; Q5TD97; -.
DR TreeFam; TF314113; -.
DR PathwayCommons; Q5TD97; -.
DR SignaLink; Q5TD97; -.
DR SIGNOR; Q5TD97; -.
DR BioGRID-ORCS; 9457; 15 hits in 1067 CRISPR screens.
DR EvolutionaryTrace; Q5TD97; -.
DR GeneWiki; FHL5; -.
DR GenomeRNAi; 9457; -.
DR Pharos; Q5TD97; Tbio.
DR PRO; PR:Q5TD97; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5TD97; protein.
DR Bgee; ENSG00000112214; Expressed in popliteal artery and 141 other tissues.
DR ExpressionAtlas; Q5TD97; baseline and differential.
DR Genevisible; Q5TD97; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd09428; LIM2_FHL5; 1.
DR InterPro; IPR037987; FHL2/3/5.
DR InterPro; IPR042947; FHL5_LIM2.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24205; PTHR24205; 1.
DR Pfam; PF00412; LIM; 4.
DR SMART; SM00132; LIM; 4.
DR PROSITE; PS00478; LIM_DOMAIN_1; 4.
DR PROSITE; PS50023; LIM_DOMAIN_2; 4.
PE 1: Evidence at protein level;
KW 3D-structure; LIM domain; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Zinc; Zinc-finger.
FT CHAIN 1..284
FT /note="Four and a half LIM domains protein 5"
FT /id="PRO_0000075742"
FT DOMAIN 39..100
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 101..160
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 161..220
FT /note="LIM zinc-binding 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 223..283
FT /note="LIM zinc-binding 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT ZN_FING 8..32
FT /note="C4-type"
FT /evidence="ECO:0000255"
FT VARIANT 35
FT /note="R -> H (in dbSNP:rs35157931)"
FT /id="VAR_056160"
FT VARIANT 204
FT /note="R -> G (in dbSNP:rs2273621)"
FT /id="VAR_056161"
FT VARIANT 211
FT /note="V -> M (in dbSNP:rs2252816)"
FT /evidence="ECO:0000269|PubMed:11327716,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334"
FT /id="VAR_022824"
FT VARIANT 243
FT /note="S -> R (in dbSNP:rs9373985)"
FT /id="VAR_056162"
FT CONFLICT 55
FT /note="L -> F (in Ref. 1; AAF85978)"
FT /evidence="ECO:0000305"
FT CONFLICT 191
FT /note="G -> D (in Ref. 6; AAH21723/AAH29490)"
FT /evidence="ECO:0000305"
FT CONFLICT 254
FT /note="K -> R (in Ref. 1; AAF85978)"
FT /evidence="ECO:0000305"
FT TURN 223..225
FT /evidence="ECO:0007829|PDB:1X68"
FT TURN 231..234
FT /evidence="ECO:0007829|PDB:1X68"
FT STRAND 237..240
FT /evidence="ECO:0007829|PDB:1X68"
FT STRAND 243..246
FT /evidence="ECO:0007829|PDB:1X68"
FT HELIX 247..249
FT /evidence="ECO:0007829|PDB:1X68"
FT TURN 253..255
FT /evidence="ECO:0007829|PDB:1X68"
FT STRAND 260..262
FT /evidence="ECO:0007829|PDB:1X68"
FT STRAND 264..267
FT /evidence="ECO:0007829|PDB:1X68"
FT STRAND 270..273
FT /evidence="ECO:0007829|PDB:1X68"
FT TURN 274..277
FT /evidence="ECO:0007829|PDB:1X68"
SQ SEQUENCE 284 AA; 32720 MW; 82C03B1EAA147C11 CRC64;
MTTAHFYCQY CTASLLGKKY VLKDDSPYCV TCYDRVFSNY CEECKKPIES DSKDLCYKDR
HWHEGCFKCT KCNHSLVEKP FAAKDERLLC TECYSNECSS KCFHCKRTIM PGSRKMEFKG
NYWHETCFVC ENCRQPIGTK PLISKESGNY CVPCFEKEFA HYCNFCKKVI TSGGITFCDQ
LWHKECFLCS GCRKDLCEEQ FMSRDDYPFC VDCYNHLYAN KCVACSKPIS GLTGAKFICF
QDSQWHSECF NCGKCSVSLV GKGFLTQNKE IFCQKCGSGM DTDI
