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FHL5_HUMAN
ID   FHL5_HUMAN              Reviewed;         284 AA.
AC   Q5TD97; B2RBD1; E1P526; Q5TD98; Q8WW21; Q9NQU2;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 158.
DE   RecName: Full=Four and a half LIM domains protein 5;
DE            Short=FHL-5;
DE   AltName: Full=Activator of cAMP-responsive element modulator in testis;
DE            Short=Activator of CREM in testis;
GN   Name=FHL5; Synonyms=ACT;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-211, FUNCTION, SUBCELLULAR
RP   LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Testis;
RX   PubMed=11327716; DOI=10.1006/bbrc.2001.4805;
RA   Palermo I., Litrico L., Emmanuele G., Giuffrida V., Sassone-Corsi P.,
RA   De Cesare D., Maria Fimia G., D'Agata R., Calogero A.E., Travali S.;
RT   "Cloning and expression of activator of CREM in testis in human testicular
RT   tissue.";
RL   Biochem. Biophys. Res. Commun. 283:406-411(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-211.
RC   TISSUE=Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-211.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   STRUCTURE BY NMR OF 222-284 IN COMPLEX WITH ZINC IONS.
RG   RIKEN structural genomics initiative (RSGI);
RT   "Solution structures of the C-terminal LIM domain of human FHL5 protein.";
RL   Submitted (NOV-2005) to the PDB data bank.
CC   -!- FUNCTION: May be involved in the regulation of spermatogenesis.
CC       Stimulates CREM transcriptional activity in a phosphorylation-
CC       independent manner. {ECO:0000269|PubMed:11327716}.
CC   -!- SUBUNIT: Interacts with CREM (via the third LIM domain). Interacts (via
CC       second LIM domain) with SPAG8. {ECO:0000250|UniProtKB:Q9WTX7}.
CC   -!- INTERACTION:
CC       Q5TD97; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-750641, EBI-11096309;
CC       Q5TD97; O43184-4: ADAM12; NbExp=3; IntAct=EBI-750641, EBI-12006944;
CC       Q5TD97; Q6ZMM2: ADAMTSL5; NbExp=3; IntAct=EBI-750641, EBI-9075891;
CC       Q5TD97; P21549: AGXT; NbExp=3; IntAct=EBI-750641, EBI-727098;
CC       Q5TD97; Q3KP44: ANKRD55; NbExp=3; IntAct=EBI-750641, EBI-14493093;
CC       Q5TD97; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-750641, EBI-11954519;
CC       Q5TD97; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-750641, EBI-11524452;
CC       Q5TD97; Q8N9N5-7: BANP; NbExp=3; IntAct=EBI-750641, EBI-16429296;
CC       Q5TD97; Q96PG8: BBC3; NbExp=3; IntAct=EBI-750641, EBI-17289784;
CC       Q5TD97; A8KA13: BCL6B; NbExp=3; IntAct=EBI-750641, EBI-10174813;
CC       Q5TD97; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-750641, EBI-744545;
CC       Q5TD97; Q86Y33-5: CDC20B; NbExp=3; IntAct=EBI-750641, EBI-11983537;
CC       Q5TD97; P27918: CFP; NbExp=3; IntAct=EBI-750641, EBI-9038570;
CC       Q5TD97; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-750641, EBI-741032;
CC       Q5TD97; Q96A83-2: COL26A1; NbExp=3; IntAct=EBI-750641, EBI-21553822;
CC       Q5TD97; P53672: CRYBA2; NbExp=3; IntAct=EBI-750641, EBI-750444;
CC       Q5TD97; P53673: CRYBA4; NbExp=3; IntAct=EBI-750641, EBI-7519711;
CC       Q5TD97; Q9UBR2: CTSZ; NbExp=3; IntAct=EBI-750641, EBI-8636823;
CC       Q5TD97; A2VCK2: DCDC2B; NbExp=3; IntAct=EBI-750641, EBI-10173222;
CC       Q5TD97; Q9Y2H0-1: DLGAP4; NbExp=3; IntAct=EBI-750641, EBI-12000556;
CC       Q5TD97; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-750641, EBI-9679045;
CC       Q5TD97; G5E9A7: DMWD; NbExp=3; IntAct=EBI-750641, EBI-10976677;
CC       Q5TD97; O96015: DNAL4; NbExp=10; IntAct=EBI-750641, EBI-742362;
CC       Q5TD97; Q86UW9: DTX2; NbExp=3; IntAct=EBI-750641, EBI-740376;
CC       Q5TD97; Q7L5A3: FAM214B; NbExp=5; IntAct=EBI-750641, EBI-745689;
CC       Q5TD97; Q8NEG0: FAM71C; NbExp=5; IntAct=EBI-750641, EBI-752049;
CC       Q5TD97; O95363: FARS2; NbExp=3; IntAct=EBI-750641, EBI-2513774;
CC       Q5TD97; A0PJY2: FEZF1; NbExp=3; IntAct=EBI-750641, EBI-11988727;
CC       Q5TD97; Q13227: GPS2; NbExp=3; IntAct=EBI-750641, EBI-713355;
CC       Q5TD97; P09211: GSTP1; NbExp=3; IntAct=EBI-750641, EBI-353467;
CC       Q5TD97; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-750641, EBI-11956675;
CC       Q5TD97; P08631-2: HCK; NbExp=3; IntAct=EBI-750641, EBI-9834454;
CC       Q5TD97; Q7Z353: HDX; NbExp=3; IntAct=EBI-750641, EBI-1052734;
CC       Q5TD97; Q9UBP5: HEY2; NbExp=3; IntAct=EBI-750641, EBI-750630;
CC       Q5TD97; P49639: HOXA1; NbExp=3; IntAct=EBI-750641, EBI-740785;
CC       Q5TD97; P17482: HOXB9; NbExp=3; IntAct=EBI-750641, EBI-745290;
CC       Q5TD97; Q14005-2: IL16; NbExp=5; IntAct=EBI-750641, EBI-17178971;
CC       Q5TD97; Q96PC2: IP6K3; NbExp=3; IntAct=EBI-750641, EBI-10990676;
CC       Q5TD97; Q99706: KIR2DL4; NbExp=3; IntAct=EBI-750641, EBI-10294579;
CC       Q5TD97; O14901: KLF11; NbExp=3; IntAct=EBI-750641, EBI-948266;
CC       Q5TD97; P25791-3: LMO2; NbExp=3; IntAct=EBI-750641, EBI-11959475;
CC       Q5TD97; Q15345: LRRC41; NbExp=3; IntAct=EBI-750641, EBI-721408;
CC       Q5TD97; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-750641, EBI-746778;
CC       Q5TD97; Q8IVT2: MISP; NbExp=3; IntAct=EBI-750641, EBI-2555085;
CC       Q5TD97; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-750641, EBI-5662487;
CC       Q5TD97; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-750641, EBI-11750983;
CC       Q5TD97; Q9NQX5: NPDC1; NbExp=5; IntAct=EBI-750641, EBI-748927;
CC       Q5TD97; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-750641, EBI-1210753;
CC       Q5TD97; P32242: OTX1; NbExp=3; IntAct=EBI-750641, EBI-740446;
CC       Q5TD97; Q13526: PIN1; NbExp=3; IntAct=EBI-750641, EBI-714158;
CC       Q5TD97; Q9HB19: PLEKHA2; NbExp=3; IntAct=EBI-750641, EBI-4401947;
CC       Q5TD97; Q494U1-3: PLEKHN1; NbExp=3; IntAct=EBI-750641, EBI-12014286;
CC       Q5TD97; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-750641, EBI-2557469;
CC       Q5TD97; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-750641, EBI-12000762;
CC       Q5TD97; Q2TAL8: QRICH1; NbExp=3; IntAct=EBI-750641, EBI-2798044;
CC       Q5TD97; Q9ULW5: RAB26; NbExp=3; IntAct=EBI-750641, EBI-958239;
CC       Q5TD97; Q8TBN0: RAB3IL1; NbExp=3; IntAct=EBI-750641, EBI-743796;
CC       Q5TD97; P63220: RPS21; NbExp=3; IntAct=EBI-750641, EBI-714051;
CC       Q5TD97; Q8IYX7: SAXO1; NbExp=3; IntAct=EBI-750641, EBI-3957636;
CC       Q5TD97; Q9BWG6: SCNM1; NbExp=6; IntAct=EBI-750641, EBI-748391;
CC       Q5TD97; O00560: SDCBP; NbExp=3; IntAct=EBI-750641, EBI-727004;
CC       Q5TD97; O94979-2: SEC31A; NbExp=3; IntAct=EBI-750641, EBI-17482477;
CC       Q5TD97; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-750641, EBI-11955083;
CC       Q5TD97; O75093: SLIT1; NbExp=3; IntAct=EBI-750641, EBI-947791;
CC       Q5TD97; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-750641, EBI-5235340;
CC       Q5TD97; O43609: SPRY1; NbExp=5; IntAct=EBI-750641, EBI-3866665;
CC       Q5TD97; O75896: TUSC2; NbExp=3; IntAct=EBI-750641, EBI-1052725;
CC       Q5TD97; Q99757: TXN2; NbExp=3; IntAct=EBI-750641, EBI-2932492;
CC       Q5TD97; Q05516: ZBTB16; NbExp=3; IntAct=EBI-750641, EBI-711925;
CC       Q5TD97; Q15973: ZNF124; NbExp=3; IntAct=EBI-750641, EBI-2555767;
CC       Q5TD97; P52739-2: ZNF131; NbExp=4; IntAct=EBI-750641, EBI-10213055;
CC       Q5TD97; P17027: ZNF23; NbExp=3; IntAct=EBI-750641, EBI-5657766;
CC       Q5TD97; P15622-3: ZNF250; NbExp=5; IntAct=EBI-750641, EBI-10177272;
CC       Q5TD97; Q9BRH9: ZNF251; NbExp=3; IntAct=EBI-750641, EBI-7254491;
CC       Q5TD97; Q9H9D4: ZNF408; NbExp=3; IntAct=EBI-750641, EBI-347633;
CC       Q5TD97; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-750641, EBI-740727;
CC       Q5TD97; Q8IYI8: ZNF440; NbExp=3; IntAct=EBI-750641, EBI-726439;
CC       Q5TD97; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-750641, EBI-10273713;
CC       Q5TD97; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-750641, EBI-745520;
CC       Q5TD97; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-750641, EBI-6427977;
CC       Q5TD97; Q6PF04: ZNF613; NbExp=3; IntAct=EBI-750641, EBI-12062855;
CC       Q5TD97; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-750641, EBI-16429014;
CC       Q5TD97; A0A0S2Z6P0: ZNF688; NbExp=3; IntAct=EBI-750641, EBI-16429989;
CC       Q5TD97; Q96H86: ZNF764; NbExp=3; IntAct=EBI-750641, EBI-745775;
CC       Q5TD97; Q5HY98: ZNF766; NbExp=3; IntAct=EBI-750641, EBI-2686489;
CC       Q5TD97; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-750641, EBI-10240849;
CC       Q5TD97; O43257: ZNHIT1; NbExp=3; IntAct=EBI-750641, EBI-347522;
CC       Q5TD97; P09022: Hoxa1; Xeno; NbExp=3; IntAct=EBI-750641, EBI-3957603;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11327716}.
CC       Note=Nuclei of round and elongated spermatids.
CC   -!- TISSUE SPECIFICITY: Testis-specific (at protein level).
CC       {ECO:0000269|PubMed:11327716}.
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DR   EMBL; AF278541; AAF85978.1; -; mRNA.
DR   EMBL; AK057611; BAG51940.1; -; mRNA.
DR   EMBL; AK223539; BAD97259.1; -; mRNA.
DR   EMBL; AK314608; BAG37178.1; -; mRNA.
DR   EMBL; AL132776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471051; EAW48503.1; -; Genomic_DNA.
DR   EMBL; CH471051; EAW48504.1; -; Genomic_DNA.
DR   EMBL; CH471051; EAW48505.1; -; Genomic_DNA.
DR   EMBL; BC021723; AAH21723.1; -; mRNA.
DR   EMBL; BC029490; AAH29490.1; -; mRNA.
DR   CCDS; CCDS5035.1; -.
DR   PIR; JC7686; JC7686.
DR   RefSeq; NP_001164278.1; NM_001170807.2.
DR   RefSeq; NP_001309395.1; NM_001322466.1.
DR   RefSeq; NP_001309396.1; NM_001322467.1.
DR   RefSeq; NP_065228.4; NM_020482.5.
DR   PDB; 1X68; NMR; -; A=222-284.
DR   PDBsum; 1X68; -.
DR   AlphaFoldDB; Q5TD97; -.
DR   SMR; Q5TD97; -.
DR   BioGRID; 114846; 101.
DR   CORUM; Q5TD97; -.
DR   IntAct; Q5TD97; 97.
DR   MINT; Q5TD97; -.
DR   STRING; 9606.ENSP00000326022; -.
DR   iPTMnet; Q5TD97; -.
DR   PhosphoSitePlus; Q5TD97; -.
DR   BioMuta; FHL5; -.
DR   DMDM; 68565455; -.
DR   MassIVE; Q5TD97; -.
DR   PaxDb; Q5TD97; -.
DR   PeptideAtlas; Q5TD97; -.
DR   PRIDE; Q5TD97; -.
DR   ProteomicsDB; 65008; -.
DR   Antibodypedia; 31954; 165 antibodies from 23 providers.
DR   DNASU; 9457; -.
DR   Ensembl; ENST00000326771.2; ENSP00000326022.2; ENSG00000112214.11.
DR   Ensembl; ENST00000450218.6; ENSP00000396390.2; ENSG00000112214.11.
DR   Ensembl; ENST00000541107.5; ENSP00000442357.1; ENSG00000112214.11.
DR   GeneID; 9457; -.
DR   KEGG; hsa:9457; -.
DR   MANE-Select; ENST00000450218.6; ENSP00000396390.2; NM_001322466.2; NP_001309395.1.
DR   UCSC; uc003pos.3; human.
DR   CTD; 9457; -.
DR   DisGeNET; 9457; -.
DR   GeneCards; FHL5; -.
DR   HGNC; HGNC:17371; FHL5.
DR   HPA; ENSG00000112214; Tissue enhanced (testis).
DR   MIM; 605126; gene.
DR   neXtProt; NX_Q5TD97; -.
DR   OpenTargets; ENSG00000112214; -.
DR   PharmGKB; PA134971720; -.
DR   VEuPathDB; HostDB:ENSG00000112214; -.
DR   eggNOG; KOG1704; Eukaryota.
DR   GeneTree; ENSGT00950000183028; -.
DR   HOGENOM; CLU_001357_2_0_1; -.
DR   InParanoid; Q5TD97; -.
DR   OMA; ERCFNCA; -.
DR   OrthoDB; 642235at2759; -.
DR   PhylomeDB; Q5TD97; -.
DR   TreeFam; TF314113; -.
DR   PathwayCommons; Q5TD97; -.
DR   SignaLink; Q5TD97; -.
DR   SIGNOR; Q5TD97; -.
DR   BioGRID-ORCS; 9457; 15 hits in 1067 CRISPR screens.
DR   EvolutionaryTrace; Q5TD97; -.
DR   GeneWiki; FHL5; -.
DR   GenomeRNAi; 9457; -.
DR   Pharos; Q5TD97; Tbio.
DR   PRO; PR:Q5TD97; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q5TD97; protein.
DR   Bgee; ENSG00000112214; Expressed in popliteal artery and 141 other tissues.
DR   ExpressionAtlas; Q5TD97; baseline and differential.
DR   Genevisible; Q5TD97; HS.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd09428; LIM2_FHL5; 1.
DR   InterPro; IPR037987; FHL2/3/5.
DR   InterPro; IPR042947; FHL5_LIM2.
DR   InterPro; IPR001781; Znf_LIM.
DR   PANTHER; PTHR24205; PTHR24205; 1.
DR   Pfam; PF00412; LIM; 4.
DR   SMART; SM00132; LIM; 4.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 4.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 4.
PE   1: Evidence at protein level;
KW   3D-structure; LIM domain; Metal-binding; Nucleus; Reference proteome;
KW   Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..284
FT                   /note="Four and a half LIM domains protein 5"
FT                   /id="PRO_0000075742"
FT   DOMAIN          39..100
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          101..160
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          161..220
FT                   /note="LIM zinc-binding 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          223..283
FT                   /note="LIM zinc-binding 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   ZN_FING         8..32
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255"
FT   VARIANT         35
FT                   /note="R -> H (in dbSNP:rs35157931)"
FT                   /id="VAR_056160"
FT   VARIANT         204
FT                   /note="R -> G (in dbSNP:rs2273621)"
FT                   /id="VAR_056161"
FT   VARIANT         211
FT                   /note="V -> M (in dbSNP:rs2252816)"
FT                   /evidence="ECO:0000269|PubMed:11327716,
FT                   ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334"
FT                   /id="VAR_022824"
FT   VARIANT         243
FT                   /note="S -> R (in dbSNP:rs9373985)"
FT                   /id="VAR_056162"
FT   CONFLICT        55
FT                   /note="L -> F (in Ref. 1; AAF85978)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        191
FT                   /note="G -> D (in Ref. 6; AAH21723/AAH29490)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        254
FT                   /note="K -> R (in Ref. 1; AAF85978)"
FT                   /evidence="ECO:0000305"
FT   TURN            223..225
FT                   /evidence="ECO:0007829|PDB:1X68"
FT   TURN            231..234
FT                   /evidence="ECO:0007829|PDB:1X68"
FT   STRAND          237..240
FT                   /evidence="ECO:0007829|PDB:1X68"
FT   STRAND          243..246
FT                   /evidence="ECO:0007829|PDB:1X68"
FT   HELIX           247..249
FT                   /evidence="ECO:0007829|PDB:1X68"
FT   TURN            253..255
FT                   /evidence="ECO:0007829|PDB:1X68"
FT   STRAND          260..262
FT                   /evidence="ECO:0007829|PDB:1X68"
FT   STRAND          264..267
FT                   /evidence="ECO:0007829|PDB:1X68"
FT   STRAND          270..273
FT                   /evidence="ECO:0007829|PDB:1X68"
FT   TURN            274..277
FT                   /evidence="ECO:0007829|PDB:1X68"
SQ   SEQUENCE   284 AA;  32720 MW;  82C03B1EAA147C11 CRC64;
     MTTAHFYCQY CTASLLGKKY VLKDDSPYCV TCYDRVFSNY CEECKKPIES DSKDLCYKDR
     HWHEGCFKCT KCNHSLVEKP FAAKDERLLC TECYSNECSS KCFHCKRTIM PGSRKMEFKG
     NYWHETCFVC ENCRQPIGTK PLISKESGNY CVPCFEKEFA HYCNFCKKVI TSGGITFCDQ
     LWHKECFLCS GCRKDLCEEQ FMSRDDYPFC VDCYNHLYAN KCVACSKPIS GLTGAKFICF
     QDSQWHSECF NCGKCSVSLV GKGFLTQNKE IFCQKCGSGM DTDI
 
 
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