ID   FHL5_MACFA              Reviewed;         284 AA.
AC   Q4R7A4; Q4R315;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Four and a half LIM domains protein 5;
DE            Short=FHL-5;
GN   Name=FHL5; ORFNames=QtsA-15776, QtsA-20333;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in the regulation of spermatogenesis.
CC       Stimulates CREM transcriptional activity in a phosphorylation-
CC       independent manner (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CREM (via the third LIM domain). Interacts (via
CC       second LIM domain) with SPAG8. {ECO:0000250|UniProtKB:Q9WTX7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Note=Nuclei of round and elongated
CC       spermatids. {ECO:0000250}.
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DR   EMBL; AB168917; BAE01018.1; -; mRNA.
DR   EMBL; AB179453; BAE02504.1; -; mRNA.
DR   RefSeq; NP_001270282.1; NM_001283353.1.
DR   RefSeq; XP_005552380.1; XM_005552323.2.
DR   AlphaFoldDB; Q4R7A4; -.
DR   SMR; Q4R7A4; -.
DR   STRING; 9541.XP_005552378.1; -.
DR   GeneID; 101926184; -.
DR   KEGG; mcf:101926184; -.
DR   CTD; 9457; -.
DR   eggNOG; KOG1704; Eukaryota.
DR   OrthoDB; 642235at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd09428; LIM2_FHL5; 1.
DR   InterPro; IPR037987; FHL2/3/5.
DR   InterPro; IPR042947; FHL5_LIM2.
DR   InterPro; IPR001781; Znf_LIM.
DR   PANTHER; PTHR24205; PTHR24205; 1.
DR   Pfam; PF00412; LIM; 4.
DR   SMART; SM00132; LIM; 4.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 4.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 4.
PE   2: Evidence at transcript level;
KW   LIM domain; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..284
FT                   /note="Four and a half LIM domains protein 5"
FT                   /id="PRO_0000265106"
FT   DOMAIN          39..100
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          101..160
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          161..220
FT                   /note="LIM zinc-binding 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          223..283
FT                   /note="LIM zinc-binding 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   ZN_FING         8..32
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        64
FT                   /note="G -> E (in Ref. 1; BAE02504)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   284 AA;  32609 MW;  6C19803C5C233C11 CRC64;
     MTTAQFYCQY CTASLLGKKY VLKDDSLFCV TCYDRVFSNY CEECKKPIES DSKDLCYKDR
     HWHGGCFKCT KCNHSLVEKP FAAKDERLLC TECYSNECSS KCFHCKRTIM PGSRKMEFKG
     NYWHETCFVC ENCRQPIGTK PLISKESGNF CVPCFEKEFA HYCNFCKKVI TSGGITFCDQ
     LWHKECFLCS GCRKDLCEEQ FMSRDDYPFC VDCYNHLYAN KCVACSKPIS GLTGAKFICF
     QDSQWHSECF NCGKCSVSLV GKGFLTQNKE IFCQKCGSGM DSDI