ID   FHL5_RAT                Reviewed;         284 AA.
AC   Q6AXT1;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Four and a half LIM domains protein 5;
DE            Short=FHL-5;
GN   Name=Fhl5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in the regulation of spermatogenesis.
CC       Stimulates CREM transcriptional activity in a phosphorylation-
CC       independent manner (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CREM (via the third LIM domain). Interacts (via
CC       second LIM domain) with SPAG8. {ECO:0000250|UniProtKB:Q9WTX7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Nuclei of round and
CC       elongated spermatids. {ECO:0000250}.
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DR   EMBL; BC079327; AAH79327.1; -; mRNA.
DR   RefSeq; NP_001013106.1; NM_001013088.1.
DR   RefSeq; XP_008761817.2; XM_008763595.2.
DR   RefSeq; XP_017448722.1; XM_017593233.1.
DR   AlphaFoldDB; Q6AXT1; -.
DR   SMR; Q6AXT1; -.
DR   STRING; 10116.ENSRNOP00000047630; -.
DR   PaxDb; Q6AXT1; -.
DR   GeneID; 297954; -.
DR   KEGG; rno:297954; -.
DR   UCSC; RGD:1307056; rat.
DR   CTD; 9457; -.
DR   RGD; 1307056; Fhl5.
DR   VEuPathDB; HostDB:ENSRNOG00000007680; -.
DR   eggNOG; KOG1704; Eukaryota.
DR   HOGENOM; CLU_001357_2_0_1; -.
DR   InParanoid; Q6AXT1; -.
DR   OMA; ERCFNCA; -.
DR   OrthoDB; 642235at2759; -.
DR   PhylomeDB; Q6AXT1; -.
DR   TreeFam; TF314113; -.
DR   PRO; PR:Q6AXT1; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000007680; Expressed in testis and 11 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003713; F:transcription coactivator activity; ISO:RGD.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   CDD; cd09428; LIM2_FHL5; 1.
DR   InterPro; IPR037987; FHL2/3/5.
DR   InterPro; IPR042947; FHL5_LIM2.
DR   InterPro; IPR001781; Znf_LIM.
DR   PANTHER; PTHR24205; PTHR24205; 1.
DR   Pfam; PF00412; LIM; 4.
DR   SMART; SM00132; LIM; 4.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 4.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 4.
PE   2: Evidence at transcript level;
KW   LIM domain; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..284
FT                   /note="Four and a half LIM domains protein 5"
FT                   /id="PRO_0000075744"
FT   DOMAIN          39..100
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          101..160
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          161..220
FT                   /note="LIM zinc-binding 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          221..283
FT                   /note="LIM zinc-binding 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   ZN_FING         8..32
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   284 AA;  32970 MW;  6FA46146D7410005 CRC64;
     MTSTQFDCQY CTASLLGKKY VLKDDNLYCI SCYDRIFSNY CEQCKEPIES DSKDLCYKNR
     HWHEGCFRCN KCHHSLVEKP FVAKDERLLC TDCYSNECSS KCFHCKRTIM PGSRKMEFKG
     NYWHETCFVC EHCRQPIGTK PLISKESGNY CVPCFEKEFA HYCNFCKKVI TSGGITFRDQ
     IWHKECFLCS GCRKELYEEA FMSKDDFPFC LDCYNHLYAK KCAACTKPIT GLRGAKFICF
     QDRQWHSECF NCGKCSVSLV GEGFLTQNME ILCRKCGSGA DTDM