FHL5_RAT
ID FHL5_RAT Reviewed; 284 AA.
AC Q6AXT1;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Four and a half LIM domains protein 5;
DE Short=FHL-5;
GN Name=Fhl5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in the regulation of spermatogenesis.
CC Stimulates CREM transcriptional activity in a phosphorylation-
CC independent manner (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CREM (via the third LIM domain). Interacts (via
CC second LIM domain) with SPAG8. {ECO:0000250|UniProtKB:Q9WTX7}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Nuclei of round and
CC elongated spermatids. {ECO:0000250}.
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DR EMBL; BC079327; AAH79327.1; -; mRNA.
DR RefSeq; NP_001013106.1; NM_001013088.1.
DR RefSeq; XP_008761817.2; XM_008763595.2.
DR RefSeq; XP_017448722.1; XM_017593233.1.
DR AlphaFoldDB; Q6AXT1; -.
DR SMR; Q6AXT1; -.
DR STRING; 10116.ENSRNOP00000047630; -.
DR PaxDb; Q6AXT1; -.
DR GeneID; 297954; -.
DR KEGG; rno:297954; -.
DR UCSC; RGD:1307056; rat.
DR CTD; 9457; -.
DR RGD; 1307056; Fhl5.
DR VEuPathDB; HostDB:ENSRNOG00000007680; -.
DR eggNOG; KOG1704; Eukaryota.
DR HOGENOM; CLU_001357_2_0_1; -.
DR InParanoid; Q6AXT1; -.
DR OMA; ERCFNCA; -.
DR OrthoDB; 642235at2759; -.
DR PhylomeDB; Q6AXT1; -.
DR TreeFam; TF314113; -.
DR PRO; PR:Q6AXT1; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000007680; Expressed in testis and 11 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003713; F:transcription coactivator activity; ISO:RGD.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR CDD; cd09428; LIM2_FHL5; 1.
DR InterPro; IPR037987; FHL2/3/5.
DR InterPro; IPR042947; FHL5_LIM2.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24205; PTHR24205; 1.
DR Pfam; PF00412; LIM; 4.
DR SMART; SM00132; LIM; 4.
DR PROSITE; PS00478; LIM_DOMAIN_1; 4.
DR PROSITE; PS50023; LIM_DOMAIN_2; 4.
PE 2: Evidence at transcript level;
KW LIM domain; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..284
FT /note="Four and a half LIM domains protein 5"
FT /id="PRO_0000075744"
FT DOMAIN 39..100
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 101..160
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 161..220
FT /note="LIM zinc-binding 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 221..283
FT /note="LIM zinc-binding 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT ZN_FING 8..32
FT /note="C4-type"
FT /evidence="ECO:0000255"
SQ SEQUENCE 284 AA; 32970 MW; 6FA46146D7410005 CRC64;
MTSTQFDCQY CTASLLGKKY VLKDDNLYCI SCYDRIFSNY CEQCKEPIES DSKDLCYKNR
HWHEGCFRCN KCHHSLVEKP FVAKDERLLC TDCYSNECSS KCFHCKRTIM PGSRKMEFKG
NYWHETCFVC EHCRQPIGTK PLISKESGNY CVPCFEKEFA HYCNFCKKVI TSGGITFRDQ
IWHKECFLCS GCRKELYEEA FMSKDDFPFC LDCYNHLYAK KCAACTKPIT GLRGAKFICF
QDRQWHSECF NCGKCSVSLV GEGFLTQNME ILCRKCGSGA DTDM