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FHUB_BACSU
ID   FHUB_BACSU              Reviewed;         384 AA.
AC   P49936;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Iron(3+)-hydroxamate import system permease protein FhuB;
DE   AltName: Full=Ferric hydroxamate uptake protein B;
DE   AltName: Full=Ferrichrome transport system permease protein FhuB;
DE   AltName: Full=Iron(III)-hydroxamate import system permease protein FhuB;
GN   Name=fhuB; OrderedLocusNames=BSU33310;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RA   Schneider R., Hantke K.;
RL   Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9639930; DOI=10.1099/00221287-144-6-1593;
RA   Wipat A., Brignell C.S., Guy J.B., Rose M., Emmerson P.T., Harwood C.R.;
RT   "The yvsA-yvqA (293 degrees - 289 degrees) region of the Bacillus subtilis
RT   chromosome containing genes involved in metal ion uptake and a putative
RT   sigma factor.";
RL   Microbiology 144:1593-1600(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-38.
RC   STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC   3610 / NRRL NRS-744 / VKM B-501;
RX   PubMed=8388528; DOI=10.1111/j.1365-2958.1993.tb01208.x;
RA   Schneider R., Hantke K.;
RT   "Iron-hydroxamate uptake systems in Bacillus subtilis: identification of a
RT   lipoprotein as part of a binding protein-dependent transport system.";
RL   Mol. Microbiol. 8:111-121(1993).
RN   [5]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC   3610 / NRRL NRS-744 / VKM B-501;
RX   PubMed=20713508; DOI=10.1101/gad.1945010;
RA   Lopez D., Kolter R.;
RT   "Functional microdomains in bacterial membranes.";
RL   Genes Dev. 24:1893-1902(2010).
CC   -!- FUNCTION: Part of the ABC transporter complex FhuBGCD involved in
CC       iron(3+)-hydroxamate import. Responsible for the translocation of the
CC       substrate across the membrane (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The complex is composed of an ATP-binding protein (FhuC), two
CC       transmembrane proteins (FhuB and FhuG) and a solute-binding protein
CC       (FhuD or YxeB). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20713508};
CC       Multi-pass membrane protein {ECO:0000305}. Membrane raft
CC       {ECO:0000269|PubMed:20713508}; Multi-pass membrane protein
CC       {ECO:0000255}. Note=Present in detergent-resistant membrane (DRM)
CC       fractions that may be equivalent to eukaryotic membrane rafts; these
CC       rafts include proteins involved in signaling, molecule trafficking and
CC       protein secretion. {ECO:0000269|PubMed:20713508}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. FecCD subfamily. {ECO:0000305}.
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DR   EMBL; X93092; CAA63643.1; -; Genomic_DNA.
DR   EMBL; AJ223978; CAA11720.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15337.1; -; Genomic_DNA.
DR   EMBL; M87283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; A69622; A69622.
DR   RefSeq; NP_391212.1; NC_000964.3.
DR   RefSeq; WP_010886613.1; NC_000964.3.
DR   AlphaFoldDB; P49936; -.
DR   SMR; P49936; -.
DR   STRING; 224308.BSU33310; -.
DR   PaxDb; P49936; -.
DR   PRIDE; P49936; -.
DR   EnsemblBacteria; CAB15337; CAB15337; BSU_33310.
DR   GeneID; 937085; -.
DR   KEGG; bsu:BSU33310; -.
DR   PATRIC; fig|224308.43.peg.3493; -.
DR   eggNOG; COG0609; Bacteria.
DR   InParanoid; P49936; -.
DR   OMA; HIVWLIR; -.
DR   PhylomeDB; P49936; -.
DR   BioCyc; BSUB:BSU33310-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0033214; P:siderophore-dependent iron import into cell; IBA:GO_Central.
DR   Gene3D; 1.10.3470.10; -; 1.
DR   InterPro; IPR037294; ABC_BtuC-like.
DR   InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR   PANTHER; PTHR30472; PTHR30472; 1.
DR   Pfam; PF01032; FecCD; 1.
DR   SUPFAM; SSF81345; SSF81345; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Iron; Iron transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..384
FT                   /note="Iron(3+)-hydroxamate import system permease protein
FT                   FhuB"
FT                   /id="PRO_0000060026"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   384 AA;  40720 MW;  7E4D75CAB36AB8FB CRC64;
     MHFHFCSKHS IKSAEKSDIL KQQLIIIISN RKEVRQLSQH KNIRTASEEI QWTSRTYGAV
     IVLIAGLCLL CLGAFLSISL GAADIHLRTV WEAIFHYQPT KTSHQIIHDL RLPRTAAAAL
     VGALLAVSGA IMQGMTRNPL AEPSIMGVTS GSAFAVSIAF AFFPGLSAMG LVLWSFAGAG
     LGASTVMGIG MFSRGGLTPV KLALAGTAVT YFFTGISTAI AIRFDVAQDI SFWYAGGVAG
     VKWSGVQLLL IAGAVGLTLA FFIARSVTVL SLGDDLAKGL GQYTSAVKLV GMLIVVILTG
     AAVSIAGTIA FIGLIIPHIT RFLVGVDYRW IIPCSAVLGA VLLVFADIAA RLVNAPFETP
     VGALTSLIGV PFFFYLARRE RRGL
 
 
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