FHUB_SALTY
ID FHUB_SALTY Reviewed; 685 AA.
AC O87656;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 19-DEC-2001, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Iron(3+)-hydroxamate import system permease protein FhuB {ECO:0000250|UniProtKB:P06972};
DE AltName: Full=Ferric hydroxamate uptake protein B {ECO:0000250|UniProtKB:P06972};
DE AltName: Full=Ferrichrome transport system permease protein FhuB {ECO:0000250|UniProtKB:P06972};
DE AltName: Full=Ferrichrome uptake protein FhuB {ECO:0000250|UniProtKB:P06972};
DE AltName: Full=Iron(III)-hydroxamate import system permease protein FhuB {ECO:0000250|UniProtKB:P06972};
GN Name=fhuB; OrderedLocusNames=STM0194;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 467-685.
RC STRAIN=ATCC 14028s / SGSG 2262;
RA Emmerth M., Goebel W., Miller S.I., Hueck C.J.;
RT "Genomic subtraction identifies Salmonella typhimurium prophages and a
RT novel fimbrial operon, stf, which are absent from S. typhi and E. coli.";
RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP FUNCTION IN DESFERRIOXAMINE TRANSPORT.
RC STRAIN=ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023;
RX PubMed=10103258; DOI=10.1128/aem.65.4.1610-1618.1999;
RA Kingsley R.A., Reissbrodt R., Rabsch W., Ketley J.M., Tsolis R.M.,
RA Everest P., Dougan G., Baeumler A.J., Roberts M., Williams P.H.;
RT "Ferrioxamine-mediated iron(III) utilization by Salmonella enterica.";
RL Appl. Environ. Microbiol. 65:1610-1618(1999).
CC -!- FUNCTION: Part of the ABC transporter complex FhuCDB involved in
CC iron(3+)-hydroxamate import. Responsible for the translocation of the
CC substrate across the membrane (By similarity). Involved in
CC ferrioxamine-mediated iron(III) utilization (PubMed:10103258).
CC {ECO:0000250|UniProtKB:P06972, ECO:0000269|PubMed:10103258}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (FhuC),
CC two transmembrane proteins (FhuB) and a solute-binding protein (FhuD).
CC {ECO:0000250|UniProtKB:P06972}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P06972}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. FecCD subfamily. {ECO:0000305}.
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DR EMBL; AE006468; AAL19158.1; -; Genomic_DNA.
DR EMBL; AF093503; AAC64151.1; -; Genomic_DNA.
DR RefSeq; NP_459199.1; NC_003197.2.
DR RefSeq; WP_000088086.1; NC_003197.2.
DR AlphaFoldDB; O87656; -.
DR SMR; O87656; -.
DR STRING; 99287.STM0194; -.
DR PaxDb; O87656; -.
DR PRIDE; O87656; -.
DR EnsemblBacteria; AAL19158; AAL19158; STM0194.
DR GeneID; 1251712; -.
DR KEGG; stm:STM0194; -.
DR PATRIC; fig|99287.12.peg.204; -.
DR HOGENOM; CLU_013016_7_3_6; -.
DR PhylomeDB; O87656; -.
DR BioCyc; SENT99287:STM0194-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0033214; P:siderophore-dependent iron import into cell; IBA:GO_Central.
DR Gene3D; 1.10.3470.10; -; 2.
DR InterPro; IPR037294; ABC_BtuC-like.
DR InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR PANTHER; PTHR30472; PTHR30472; 1.
DR Pfam; PF01032; FecCD; 2.
DR SUPFAM; SSF81345; SSF81345; 2.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Ion transport; Iron; Iron transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..685
FT /note="Iron(3+)-hydroxamate import system permease protein
FT FhuB"
FT /id="PRO_0000060029"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 328..348
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 479..499
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 504..524
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 553..573
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 592..612
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 632..652
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 660..680
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 470..479
FT /note="NAFGWLLPAG -> KPSGWYCLAE (in Ref. 2; AAC64151)"
FT /evidence="ECO:0000305"
FT CONFLICT 484..487
FT /note="AATL -> RRHW (in Ref. 2; AAC64151)"
FT /evidence="ECO:0000305"
FT CONFLICT 531..532
FT /note="AE -> PK (in Ref. 2; AAC64151)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 685 AA; 73204 MW; 547C0ACC551B353D CRC64;
MSRKREMPDG GAKSVLSDLR FGRFVGRIRR SRHPALLLLA LFVAACWLTW VNFSVALPRS
QWQQAIWSPD IDIIEQMIFH YSQLPRLAIS LLVGAGLGLV GVLFQQVLRN PLAEPTTLGV
ATGAQLGITV TTLWAIPGAL TTQFAALTGA CIVGALVFGV AWGKRLSPVT LILAGLVVSL
YCGAINQLLV IFHHDQLQSM FLWSTGTLTQ TDWSGVQRLW PQLLGGVMLT LLLLRPMTLM
GLDDGVARNL GLALSLARLA ALSLAIVLSA LLVNAVGIIG FIGLFAPLLA KMLGARRLLA
RLMLAPLIGA LILWLSDQII LWLTRVWMEV STGSVTALIG APLLLWLLPR LKSMSAPDMN
ASDRVAAERR HVLAFAVAGG ALLLLATWVA LSFGRDAHGW TWASGTLLEE LMPWRWPRIL
AALMAGVMLA VAGCIIQRLT GNPMASPEVL GISSGAAFGV VLMLFLVPGN AFGWLLPAGS
LGAAATLLII MIAAGRGGFS PQRMLLAGMA LSTAFTMLLM MLQASGDPRM AEVLTWLSGS
TYNATGGQVT RTAIVMVILL AIVPLCRRWL TILPLGGDAA RAVGMALTPS RIALLALAAC
LTATATMTIG PLSFVGLMAP HIARMLGFRR TMPHMVISAL AGGVLLVFAD WCGRMALFPY
QIPAGLLSSF IGAPYFIYLL RKQSR
