ID   FHUC_BACSU              Reviewed;         269 AA.
AC   P49938;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=Iron(3+)-hydroxamate import ATP-binding protein FhuC;
DE            EC=7.2.2.16;
DE   AltName: Full=Ferric hydroxamate uptake protein C;
DE   AltName: Full=Ferrichrome transport ATP-binding protein FhuC;
DE   AltName: Full=Iron(III)-hydroxamate import ATP-binding protein FhuC;
GN   Name=fhuC; OrderedLocusNames=BSU33290;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RA   Schneider R., Hantke K.;
RL   Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9639930; DOI=10.1099/00221287-144-6-1593;
RA   Wipat A., Brignell C.S., Guy J.B., Rose M., Emmerson P.T., Harwood C.R.;
RT   "The yvsA-yvqA (293 degrees - 289 degrees) region of the Bacillus subtilis
RT   chromosome containing genes involved in metal ion uptake and a putative
RT   sigma factor.";
RL   Microbiology 144:1593-1600(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- FUNCTION: Part of the ABC transporter complex FhuBGCD involved in
CC       iron(3+)-hydroxamate import. Responsible for energy coupling to the
CC       transport system (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + Fe(3+)-hydroxamate complex-[hydroxamate-binding
CC         protein]Side 1 = ADP + phosphate + Fe(3+)-hydroxamate complexSide 2 +
CC         [hydroxamate-binding protein]Side 1.; EC=7.2.2.16;
CC   -!- SUBUNIT: The complex is composed of an ATP-binding protein (FhuC), two
CC       transmembrane proteins (FhuB and FhuG) and a solute-binding protein
CC       (FhuD or YxeB). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Iron (Fe3+)-
CC       hydroxamate importer (TC 3.A.1.14.7) family. {ECO:0000305}.
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DR   EMBL; X93092; CAA63645.1; -; Genomic_DNA.
DR   EMBL; AJ223978; CAA11722.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15335.1; -; Genomic_DNA.
DR   PIR; B69622; B69622.
DR   RefSeq; NP_391210.1; NC_000964.3.
DR   RefSeq; WP_003243882.1; NZ_JNCM01000033.1.
DR   AlphaFoldDB; P49938; -.
DR   SMR; P49938; -.
DR   STRING; 224308.BSU33290; -.
DR   PaxDb; P49938; -.
DR   DNASU; 935994; -.
DR   EnsemblBacteria; CAB15335; CAB15335; BSU_33290.
DR   GeneID; 935994; -.
DR   KEGG; bsu:BSU33290; -.
DR   PATRIC; fig|224308.179.peg.3613; -.
DR   eggNOG; COG1120; Bacteria.
DR   InParanoid; P49938; -.
DR   OMA; FHIDAEI; -.
DR   PhylomeDB; P49938; -.
DR   BioCyc; BSUB:BSU33290-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015625; F:ABC-type ferric hydroxamate transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Ion transport; Iron; Iron transport; Membrane;
KW   Nucleotide-binding; Reference proteome; Translocase; Transport.
FT   CHAIN           1..269
FT                   /note="Iron(3+)-hydroxamate import ATP-binding protein
FT                   FhuC"
FT                   /id="PRO_0000092326"
FT   DOMAIN          4..240
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         36..43
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         160..171
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   269 AA;  29955 MW;  656460D1BC130B87 CRC64;
     MNSLSTEQLG IGYGDRVIVE DLNISIPKGK ITTLIGPNGC GKSTILKTMS RIMRSHAGAV
     YLNGKAIHKM STKDIAKDMA ILPQTPEAPS GLTVHELVSY GRFPHQSGFG RLNDEDRRII
     KWALEETGMA EYAERPIEAL SGGQRQRVWI AMALAQGTEL LLLDEPTTYL DLAHQLEILQ
     LLDRLNKEQG RTILMVIHDL NHAARFSHYM IALKKGTVIK EGTALEVMTP DILKQVFQID
     AEIVTDPRTN KPVCLTYDLI KNEKELVTV