ID   AKD1B_HUMAN             Reviewed;         528 AA.
AC   A6NHY2;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2013, sequence version 3.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Ankyrin repeat and death domain-containing protein 1B;
GN   Name=ANKDD1B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
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DR   EMBL; AC010245; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS64180.1; -.
DR   RefSeq; NP_001263642.1; NM_001276713.1.
DR   AlphaFoldDB; A6NHY2; -.
DR   SMR; A6NHY2; -.
DR   BioGRID; 609197; 1.
DR   STRING; 9606.ENSP00000471417; -.
DR   iPTMnet; A6NHY2; -.
DR   PhosphoSitePlus; A6NHY2; -.
DR   BioMuta; ANKDD1B; -.
DR   PaxDb; A6NHY2; -.
DR   PeptideAtlas; A6NHY2; -.
DR   PRIDE; A6NHY2; -.
DR   ProteomicsDB; 1232; -.
DR   Antibodypedia; 71745; 54 antibodies from 12 providers.
DR   DNASU; 728780; -.
DR   Ensembl; ENST00000601380.4; ENSP00000471417.1; ENSG00000189045.15.
DR   GeneID; 728780; -.
DR   KEGG; hsa:728780; -.
DR   MANE-Select; ENST00000601380.4; ENSP00000471417.1; NM_001276713.2; NP_001263642.1.
DR   UCSC; uc031ski.2; human.
DR   CTD; 728780; -.
DR   DisGeNET; 728780; -.
DR   GeneCards; ANKDD1B; -.
DR   HGNC; HGNC:32525; ANKDD1B.
DR   HPA; ENSG00000189045; Tissue enhanced (fallopian).
DR   neXtProt; NX_A6NHY2; -.
DR   OpenTargets; ENSG00000189045; -.
DR   VEuPathDB; HostDB:ENSG00000189045; -.
DR   eggNOG; KOG4177; Eukaryota.
DR   GeneTree; ENSGT00940000154170; -.
DR   HOGENOM; CLU_000134_51_1_1; -.
DR   InParanoid; A6NHY2; -.
DR   OMA; SYQEHGN; -.
DR   OrthoDB; 1073550at2759; -.
DR   PhylomeDB; A6NHY2; -.
DR   PathwayCommons; A6NHY2; -.
DR   SignaLink; A6NHY2; -.
DR   BioGRID-ORCS; 728780; 10 hits in 1037 CRISPR screens.
DR   ChiTaRS; ANKDD1B; human.
DR   GenomeRNAi; 728780; -.
DR   Pharos; A6NHY2; Tdark.
DR   PRO; PR:A6NHY2; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; A6NHY2; protein.
DR   Bgee; ENSG00000189045; Expressed in right uterine tube and 95 other tissues.
DR   ExpressionAtlas; A6NHY2; baseline and differential.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.533.10; -; 1.
DR   Gene3D; 1.25.40.20; -; 3.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   Pfam; PF12796; Ank_2; 3.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 10.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 6.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
PE   4: Predicted;
KW   ANK repeat; Reference proteome; Repeat.
FT   CHAIN           1..528
FT                   /note="Ankyrin repeat and death domain-containing protein
FT                   1B"
FT                   /id="PRO_0000332160"
FT   REPEAT          67..96
FT                   /note="ANK 1"
FT   REPEAT          100..129
FT                   /note="ANK 2"
FT   REPEAT          133..162
FT                   /note="ANK 3"
FT   REPEAT          166..197
FT                   /note="ANK 4"
FT   REPEAT          201..230
FT                   /note="ANK 5"
FT   REPEAT          234..263
FT                   /note="ANK 6"
FT   REPEAT          267..296
FT                   /note="ANK 7"
FT   REPEAT          300..329
FT                   /note="ANK 8"
FT   REPEAT          333..362
FT                   /note="ANK 9"
FT   REPEAT          366..395
FT                   /note="ANK 10"
FT   DOMAIN          427..515
FT                   /note="Death"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00064"
SQ   SEQUENCE   528 AA;  59088 MW;  5C3FF9A1A2A54859 CRC64;
     MDPAGRARGQ GATAGGLLLR AAAAAKGLRE DLWGAAALPW RSLSRIPKRE GLGEEDTAVA
     GHELLLPNER SFQNAAKSNN LDLMEKLFEK KVNINVVNNM NRTALHFAVG RNHLSAVDFL
     LKHKARVDVA DKHGLTVIHL AAWSGSLEVM LMLVKAGADQ RAKNQDGMSA LHFATQSNHV
     RIVEYLIQDL HLKDLNQPDE KGRKPFLLAA ERGHVEMIEK LTFLNLHTSE KDKGGNTALH
     LAAKHGHSPA VQVLLAQWQD INEMNELNIS SLQIATRNGH ASLVNFLLSE NVDLHQKVEP
     KESPLHLVVI NNHITVVNSL LSAQHDIDIL NQKQQTPLHV AADRGNVELV ETLLKAGCDL
     KAVDKQGKTA LAVASRSNHS LVVGMLIKAE RYYAWREEHH ESIRDPSTGF TLTFKQDHSL
     ETRHIRTLLW DLAYHQLKAN EWQRLARSWN FTDDQIRAIE EQWSGNESFR EHGHRALLIW
     LHGTLMTQGD PAKQLYEELV HAGFPKLAEK TRHFKSKTDS NSKKCVVS