AKH1A_AGRIP
ID AKH1A_AGRIP Reviewed; 68 AA.
AC C0HL91; C0HKR0;
DT 23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT 23-MAY-2018, sequence version 1.
DT 25-MAY-2022, entry version 6.
DE RecName: Full=Adipokinetic prohormone type 1 {ECO:0000250|UniProtKB:P55319};
DE Contains:
DE RecName: Full=Adipokinetic hormone 1 {ECO:0000303|PubMed:29466015};
DE Short=AKH-1 {ECO:0000303|PubMed:29466015};
DE Flags: Precursor;
OS Agrotis ipsilon (Black cutworm moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Noctuinae; Noctuini; Agrotis.
OX NCBI_TaxID=56364 {ECO:0000303|PubMed:29466015};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 21-30, TISSUE SPECIFICITY,
RP MASS SPECTROMETRY, IDENTIFICATION BY MASS SPECTROMETRY, AMIDATION AT
RP GLY-30, AND PYROGLUTAMATE FORMATION AT GLN-21.
RX PubMed=29466015; DOI=10.1021/acs.jproteome.7b00779;
RA Diesner M., Gallot A., Binz H., Gaertner C., Vitecek S., Kahnt J.,
RA Schachtner J., Jacquin-Joly E., Gadenne C.;
RT "Mating-induced differential peptidomics of neuropeptides and protein
RT hormones in Agrotis ipsilon moths.";
RL J. Proteome Res. 17:1397-1414(2018).
CC -!- FUNCTION: This hormone, released from cells in the corpora cardiaca,
CC causes release of diglycerides from the fat body and stimulation of
CC muscles to use these diglycerides as an energy source during energy-
CC demanding processes. {ECO:0000250|UniProtKB:P55319}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in antennal lobe (AL), corpora cardiaca
CC (CC), corpora allata (CA) and gnathal ganglion (GNG) (at protein
CC level). Expression in CC and CA detected in all animals, expression in
CC GNG in some animals and in AL in few animals (at protein level).
CC {ECO:0000269|PubMed:29466015}.
CC -!- MASS SPECTROMETRY: Mass=1087.49; Mass_error=0.01; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:29466015};
CC -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
CC -!- CAUTION: The mature peptide AKH-1 is also encoded by another precursor
CC (AC C0HL92). {ECO:0000305}.
CC -!- CAUTION: Further mature peptides might exist. {ECO:0000305}.
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DR AlphaFoldDB; C0HL91; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR002047; Adipokinetic_hormone_CS.
DR InterPro; IPR010475; AKH/RPCH_hormone.
DR Pfam; PF06377; Adipokin_hormo; 1.
DR PROSITE; PS00256; AKH; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Hormone; Neuropeptide; Pyrrolidone carboxylic acid; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PEPTIDE 21..30
FT /note="Adipokinetic hormone 1"
FT /evidence="ECO:0000269|PubMed:29466015"
FT /id="PRO_0000444169"
FT PROPEP 34..68
FT /evidence="ECO:0000305"
FT /id="PRO_0000444170"
FT MOD_RES 21
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:29466015"
FT MOD_RES 30
FT /note="Glycine amide"
FT /evidence="ECO:0000269|PubMed:29466015"
SQ SEQUENCE 68 AA; 7369 MW; 9265E7EF536FD135 CRC64;
MNYVSIFVLI VACLCVLADA QLTFTSSWGG GKRGAVAATM SCRSEETIAA IYKLIQNEAE
RLLLCQKP
