位置:首页 > 蛋白库 > FIBER_BPSPP
FIBER_BPSPP
ID   FIBER_BPSPP             Reviewed;        1111 AA.
AC   Q0PDK6;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   29-SEP-2021, entry version 47.
DE   RecName: Full=Tail spike protein {ECO:0000305};
DE            Short=TSP;
DE   AltName: Full=Gene product 21;
DE            Short=Gp21;
GN   Name=21;
OS   Bacillus phage SPP1 (Bacteriophage SPP1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae.
OX   NCBI_TaxID=10724;
OH   NCBI_TaxID=1423; Bacillus subtilis.
RN   [1] {ECO:0000312|Proteomes:UP000002559}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9434185; DOI=10.1016/s0378-1119(97)00547-7;
RA   Alonso J.C., Luder G., Stiege A.C., Chai S., Weise F., Trautner T.A.;
RT   "The complete nucleotide sequence and functional organization of Bacillus
RT   subtilis bacteriophage SPP1.";
RL   Gene 204:201-212(1997).
RN   [2]
RP   FUNCTION, DOMAIN, INTERACTION WITH HOST YUEB, AND SUBCELLULAR LOCATION.
RX   PubMed=22171743; DOI=10.1111/j.1365-2958.2011.07931.x;
RA   Vinga I., Baptista C., Auzat I., Petipas I., Lurz R., Tavares P.,
RA   Santos M.A., Sao-Jose C.;
RT   "Role of bacteriophage SPP1 tail spike protein gp21 on host cell receptor
RT   binding and trigger of phage DNA ejection.";
RL   Mol. Microbiol. 83:289-303(2012).
CC   -!- FUNCTION: Binds to the host entry receptor YueB and triggers viral DNA
CC       ejection. Binding to Yueb. This interaction initiates a cascade of
CC       conformational changes at the gp21 C-terminus causing disassembly of
CC       the tail spike organization and opening of the cap region formed by the
CC       N-terminus of gp21. {ECO:0000269|PubMed:22171743}.
CC   -!- SUBUNIT: Interacts with host Yueb receptor; this interaction triggers
CC       viral DNA ejection. {ECO:0000269|PubMed:22171743}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305|PubMed:22171743}.
CC   -!- DOMAIN: The N-terminus is part of the distal tail cap. The C-terminus
CC       is part of the spike structure and is probably involved in host
CC       receptor binding. {ECO:0000269|PubMed:22171743}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X97918; CAL18688.1; -; Genomic_DNA.
DR   RefSeq; YP_009268706.1; NC_004166.2.
DR   SMR; Q0PDK6; -.
DR   GeneID; 955339; -.
DR   KEGG; vg:955339; -.
DR   Proteomes; UP000002559; Genome.
DR   GO; GO:0098024; C:virus tail, fiber; IDA:UniProtKB.
DR   GO; GO:0098670; P:entry receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR   GO; GO:0099001; P:viral genome ejection through host cell envelope, long flexible tail mechanism; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IDA:UniProtKB.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR007119; Phage_minor_struct_N.
DR   TIGRFAMs; TIGR01665; put_anti_recept; 1.
PE   1: Evidence at protein level;
KW   Host-virus interaction; Reference proteome; Viral attachment to host cell;
KW   Viral attachment to host entry receptor;
KW   Viral genome ejection through host cell envelope;
KW   Viral long flexible tail ejection system;
KW   Viral penetration into host cytoplasm; Virion; Virus entry into host cell.
FT   CHAIN           1..1111
FT                   /note="Tail spike protein"
FT                   /id="PRO_0000438142"
SQ   SEQUENCE   1111 AA;  123953 MW;  6743A97C141BE172 CRC64;
     MRSLSKNIWI MSNFEVLLTT LTGDRDAGGC RYWNGSFEEP LSPGETATYQ FYADASHPNS
     KYVINDNKVI FKEPEQFGGD YRMFTIIDTE LGRSEQDGRY IIATCEPAWY ELDDDFIENK
     RPTDKTPQEA LDLLLEGTRY EGEVDPDLQM RASDSFYQVS VKEAVIQFFQ TWGGYFKDTI
     EFDGNEITRR VIKSLKRRGA ANGVRFEHDK DITSIRRNIT GYPKTALYPY GASLEMTDED
     GNATGGYTRY IDIKDVVWSK AAGDPVDKPA GQAWIGDPDL LKVFGRPMPD GSLRHRWTRW
     QNEDITTPEE LIEAAYYDLI NNVSKAIVNY NVEVAPKNVK LGDTCIILDR EFATPIELEA
     DVIKMTYFTD RPEEGATIEL GEYLNLDDIE RQIGAINDRF KKNEGKWNTG GGITEVTDGA
     FPDKKPPKPS NITVKSMFQS IFLSWNYDPS SYIAGYRVYA SKTPGFTPTD NDIIFEGKMS
     GYEHKVGNNE TWYYRLSTVN YHKTESDMSD QYSAQSERIM NDDILFGAIT ADKLANLAVT
     ADKISRSFDE GNIFPGSLLK PSQFYDYPNT KHSVTDKTFN ELTITQVIDD STRLRFGISG
     QNKAPNNIQR MPLEQGQIYT LSFEVKRNNT TDLSYIHLKK PDNTFMLLSS SLKDISAYPS
     DEFVRVDLQF TAPETSSKFT LGFGGYNRNG NVTPCSFVIR KVQVRKGTEI KDYGYSPYDI
     MLVDGAIYSD YIQSAAINSA HIADAAIGSA AIQNAAIKNA HLGTAIVDTA NIKDAAITSA
     KIKELSADLI TSGTINAINI TGSLIRGGRF EPLNESSAYT SYIEGDKIYQ RVNTINYGGT
     PKKTYNDLTI TSGGVTMVYG GRDTGTDEPL REMTLRDGSL YMSGNKNDTG YSEIQMYCND
     DDVVNAPKSI FRQKLGGVNR MSLHSYYNSV PGSYNVQMDT RNTSIYSHFA NGWQLTADGK
     IMIMSKNGQG IYLDPSNDNV AGQVTMHVGN AGQAGGLIQP VIAGAPHYSI TDIHGALQTN
     MSVMLYQYNF VMPSKGDAYA SKYNDIPPPF ECENIFMVVP TVFGGYSDHV HATITSQSSS
     GFRCYVRGTG SSTGILGRTF QVRFLIFYEV N
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024