FIBER_BPT7
ID FIBER_BPT7 Reviewed; 553 AA.
AC P03748;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Tail fiber protein;
DE AltName: Full=Gene product 17;
DE Short=Gp17;
DE AltName: Full=Tail fiber protein gp17;
GN OrderedLocusNames=17;
OS Escherichia phage T7 (Bacteriophage T7).
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Caudovirales; Autographiviridae; Studiervirinae; Teseptimavirus.
OX NCBI_TaxID=10760;
OH NCBI_TaxID=562; Escherichia coli.
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=6864790; DOI=10.1016/s0022-2836(83)80282-4;
RA Dunn J.J., Studier F.W.;
RT "Complete nucleotide sequence of bacteriophage T7 DNA and the locations of
RT T7 genetic elements.";
RL J. Mol. Biol. 166:477-535(1983).
RN [2]
RP SUBUNIT.
RX PubMed=3259634; DOI=10.1016/0022-2836(88)90246-x;
RA Steven A.C., Trus B.L., Maizel J.V., Unser M., Parry D.A., Wall J.S.,
RA Hainfeld J.F., Studier F.W.;
RT "Molecular substructure of a viral receptor-recognition protein. The gp17
RT tail-fiber of bacteriophage T7.";
RL J. Mol. Biol. 200:351-365(1988).
RN [3]
RP FUNCTION, AND INTERACTION WITH GP11 AND GP12.
RX PubMed=23884409; DOI=10.1074/jbc.m113.491209;
RA Cuervo A., Pulido-Cid M., Chagoyen M., Arranz R., Gonzalez-Garcia V.A.,
RA Garcia-Doval C., Caston J.R., Valpuesta J.M., van Raaij M.J.,
RA Martin-Benito J., Carrascosa J.L.;
RT "Structural characterization of the bacteriophage T7 tail machinery.";
RL J. Biol. Chem. 288:26290-26299(2013).
RN [4]
RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 371-553.
RX PubMed=22645347; DOI=10.1073/pnas.1119719109;
RA Garcia-Doval C., van Raaij M.J.;
RT "Structure of the receptor-binding carboxy-terminal domain of bacteriophage
RT T7 tail fibers.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:9390-9395(2012).
CC -!- FUNCTION: Structural component of the short non-contractile tail. The
CC tail comprises six fibers made of gp17 trimers, 2 nm in diameter and 32
CC nm in length. May attach to host lipopolysaccharides (LPS) to mediate
CC primary attachment to the host cell. {ECO:0000269|PubMed:23884409}.
CC -!- SUBUNIT: Homotrimerizes. Interacts with tail components gp11 and gp12.
CC {ECO:0000269|PubMed:23884409, ECO:0000269|PubMed:3259634}.
CC -!- INTERACTION:
CC P03748; P03748: 17; NbExp=2; IntAct=EBI-8665096, EBI-8665096;
CC -!- SUBCELLULAR LOCATION: Virion.
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DR EMBL; V01146; CAA24435.1; -; Genomic_DNA.
DR PIR; A04373; TLBPF7.
DR RefSeq; NP_042005.1; NC_001604.1.
DR PDB; 4A0T; X-ray; 1.90 A; A/B/C=371-553.
DR PDB; 4A0U; X-ray; 2.00 A; A/B/C=371-553.
DR PDB; 7BOZ; EM; 3.80 A; a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r=1-553.
DR PDB; 7EY7; EM; 4.30 A; a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r=1-553.
DR PDB; 7EY9; EM; 3.40 A; a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r=1-553.
DR PDBsum; 4A0T; -.
DR PDBsum; 4A0U; -.
DR PDBsum; 7BOZ; -.
DR PDBsum; 7EY7; -.
DR PDBsum; 7EY9; -.
DR SMR; P03748; -.
DR DIP; DIP-41671N; -.
DR MINT; P03748; -.
DR GeneID; 1261023; -.
DR KEGG; vg:1261023; -.
DR Proteomes; UP000000840; Genome.
DR GO; GO:0098024; C:virus tail, fiber; IDA:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0098671; P:adhesion receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IDA:UniProtKB.
DR InterPro; IPR022246; Phage_T7_Gp17_C.
DR InterPro; IPR005604; Phage_T7_tail_fibre.
DR Pfam; PF12604; gp37_C; 1.
DR Pfam; PF03906; Phage_T7_tail; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Host-virus interaction; Late protein; Reference proteome;
KW Viral attachment to host adhesion receptor; Viral attachment to host cell;
KW Viral tail fiber protein; Viral tail protein; Virion;
KW Virus entry into host cell.
FT CHAIN 1..553
FT /note="Tail fiber protein"
FT /id="PRO_0000106531"
FT REGION 180..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT STRAND 6..12
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 19..21
FT /evidence="ECO:0007829|PDB:7EY9"
FT HELIX 29..31
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 32..35
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 38..40
FT /evidence="ECO:0007829|PDB:7EY9"
FT TURN 46..49
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 51..54
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 57..59
FT /evidence="ECO:0007829|PDB:7EY9"
FT HELIX 66..68
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 72..77
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 81..83
FT /evidence="ECO:0007829|PDB:7EY9"
FT HELIX 96..119
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 125..127
FT /evidence="ECO:0007829|PDB:7EY9"
FT STRAND 373..379
FT /evidence="ECO:0007829|PDB:4A0T"
FT STRAND 384..390
FT /evidence="ECO:0007829|PDB:4A0T"
FT STRAND 393..400
FT /evidence="ECO:0007829|PDB:4A0T"
FT STRAND 402..404
FT /evidence="ECO:0007829|PDB:4A0T"
FT STRAND 408..412
FT /evidence="ECO:0007829|PDB:4A0T"
FT TURN 413..416
FT /evidence="ECO:0007829|PDB:4A0T"
FT STRAND 417..421
FT /evidence="ECO:0007829|PDB:4A0T"
FT STRAND 423..430
FT /evidence="ECO:0007829|PDB:4A0T"
FT STRAND 432..434
FT /evidence="ECO:0007829|PDB:4A0T"
FT STRAND 437..439
FT /evidence="ECO:0007829|PDB:4A0T"
FT HELIX 448..450
FT /evidence="ECO:0007829|PDB:4A0T"
FT HELIX 455..462
FT /evidence="ECO:0007829|PDB:4A0T"
FT STRAND 470..476
FT /evidence="ECO:0007829|PDB:4A0T"
FT STRAND 483..485
FT /evidence="ECO:0007829|PDB:4A0T"
FT STRAND 494..498
FT /evidence="ECO:0007829|PDB:4A0T"
FT HELIX 500..502
FT /evidence="ECO:0007829|PDB:4A0T"
FT STRAND 504..508
FT /evidence="ECO:0007829|PDB:4A0T"
FT STRAND 511..517
FT /evidence="ECO:0007829|PDB:4A0T"
FT STRAND 522..529
FT /evidence="ECO:0007829|PDB:4A0T"
FT TURN 530..533
FT /evidence="ECO:0007829|PDB:4A0T"
FT STRAND 534..542
FT /evidence="ECO:0007829|PDB:4A0T"
FT STRAND 547..551
FT /evidence="ECO:0007829|PDB:4A0T"
SQ SEQUENCE 553 AA; 61572 MW; 9B8B2DFADBD8EAC1 CRC64;
MANVIKTVLT YQLDGSNRDF NIPFEYLARK FVVVTLIGVD RKVLTINTDY RFATRTTISL
TKAWGPADGY TTIELRRVTS TTDRLVDFTD GSILRAYDLN VAQIQTMHVA EEARDLTTDT
IGVNNDGHLD ARGRRIVNLA NAVDDRDAVP FGQLKTMNQN SWQARNEALQ FRNEAETFRN
QAEGFKNESS TNATNTKQWR DETKGFRDEA KRFKNTAGQY ATSAGNSASA AHQSEVNAEN
SATASANSAH LAEQQADRAE READKLENYN GLAGAIDKVD GTNVYWKGNI HANGRLYMTT
NGFDCGQYQQ FFGGVTNRYS VMEWGDENGW LMYVQRREWT TAIGGNIQLV VNGQIITQGG
AMTGQLKLQN GHVLQLESAS DKAHYILSKD GNRNNWYIGR GSDNNNDCTF HSYVHGTTLT
LKQDYAVVNK HFHVGQAVVA TDGNIQGTKW GGKWLDAYLR DSFVAKSKAW TQVWSGSAGG
GVSVTVSQDL RFRNIWIKCA NNSWNFFRTG PDGIYFIASD GGWLRFQIHS NGLGFKNIAD
SRSVPNAIMV ENE
