ID   FIBER_LAMBD             Reviewed;         774 AA.
AC   P03764; P03745;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   02-JUN-2021, entry version 109.
DE   RecName: Full=Tail fiber protein {ECO:0000305};
DE            Short=stf;
DE   AltName: Full=Gene product 27 {ECO:0000305};
DE            Short=gp27;
GN   Name=stf; OrderedLocusNames=lambdap27;
OS   Escherichia phage lambda (Bacteriophage lambda).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae; Lambdavirus.
OX   NCBI_TaxID=10710;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=6221115; DOI=10.1016/0022-2836(82)90546-0;
RA   Sanger F., Coulson A.R., Hong G.F., Hill D.F., Petersen G.B.;
RT   "Nucleotide sequence of bacteriophage lambda DNA.";
RL   J. Mol. Biol. 162:729-773(1982).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=1531648; DOI=10.1128/jb.174.5.1462-1477.1992;
RA   Haggaard-Ljungquist E., Halling C., Calendar R.;
RT   "DNA sequences of the tail fiber genes of bacteriophage P2: evidence for
RT   horizontal transfer of tail fiber genes among unrelated bacteriophages.";
RL   J. Bacteriol. 174:1462-1477(1992).
RN   [3]
RP   CONCEPTUAL TRANSLATION.
RX   PubMed=1439823; DOI=10.1126/science.1439823;
RA   Hendrix R.W., Duda R.L.;
RT   "Bacteriophage lambda PaPa: not the mother of all lambda phages.";
RL   Science 258:1145-1148(1992).
CC   -!- FUNCTION: Forms tail fibers that play a role in primary attachment of
CC       virion to host receptors. Assembles with Tail fiber assembly protein to
CC       form fibers attached to virion tail tip. Fibers are about 35nm long and
CC       have a thin, uniform diameter. There are presumaby six fibers per
CC       virion. They bind in a reversible manner to host molecules, attaching
CC       transiently the virion to the host until tail tip interacts with LamB
CC       and injects viral DNA into the cell.
CC   -!- SUBUNIT: Interacts with Tail fiber assembly protein. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the tail fiber family. {ECO:0000305}.
CC   -!- CAUTION: The current laboratory strain of bacteriophage lambda are
CC       descendants of a recombinant, lambdaPaPa derived from cross between
CC       strains lambda Pasadena (Caltech) and Paris (Institut Pasteur). These
CC       stains carry a frameshift mutation relative to lambda originally
CC       derived from the original K12 E-Coli strain, called Ur-lambda. The Ur-
CC       lambda virions have thin, jointed tail fibers (side tail fibers) that
CC       are absent from lambda wild-type. Relative to lambda PaPa, Ur-lambda
CC       has expanded receptor specificity and adsorbs to E.coli cells more
CC       rapidly. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA96555.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AAA96557.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; J02459; AAA96555.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; J02459; AAA96557.1; ALT_FRAME; Genomic_DNA.
DR   PIR; C43009; QXBP2L.
DR   PIR; G43010; QXBP1L.
DR   RefSeq; NP_040602.1; NC_001416.1.
DR   RefSeq; NP_040604.1; NC_001416.1.
DR   SMR; P03764; -.
DR   IntAct; P03764; 1.
DR   GeneID; 2703518; -.
DR   GeneID; 2703519; -.
DR   KEGG; vg:2703518; -.
DR   KEGG; vg:2703519; -.
DR   Proteomes; UP000001711; Genome.
DR   GO; GO:0098024; C:virus tail, fiber; IDA:CACAO.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0098671; P:adhesion receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR   GO; GO:0046813; P:receptor-mediated virion attachment to host cell; IDA:CACAO.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IDA:CACAO.
DR   Gene3D; 3.90.1340.10; -; 1.
DR   InterPro; IPR008969; CarboxyPept-like_regulatory.
DR   InterPro; IPR005003; Phage_lambda_Stf-r1.
DR   InterPro; IPR005068; Phage_lambda_Stf-r2.
DR   InterPro; IPR011083; Phage_tail_collar_dom.
DR   InterPro; IPR037053; Phage_tail_collar_dom_sf.
DR   InterPro; IPR013609; Stf-like_N.
DR   Pfam; PF07484; Collar; 1.
DR   Pfam; PF03335; Phage_fiber; 5.
DR   Pfam; PF03406; Phage_fiber_2; 1.
DR   Pfam; PF08400; phage_tail_N; 1.
DR   SUPFAM; SSF49464; SSF49464; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Late protein; Reference proteome;
KW   Viral attachment to host adhesion receptor; Viral attachment to host cell;
KW   Viral tail fiber protein; Viral tail protein; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..774
FT                   /note="Tail fiber protein"
FT                   /id="PRO_0000077740"
FT   REGION          159..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          240..295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          589..615
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        159..174
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        245..290
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        593..615
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   774 AA;  77528 MW;  CDD1DF85E919123B CRC64;
     MAVKISGVLK DGTGKPVQNC TIQLKARRNS TTVVVNTVGS ENPDEAGRYS MDVEYGQYSV
     ILQVDGFPPS HAGTITVYED SQPGTLNDFL CAMTEDDARP EVLRRLELMV EEVARNASVV
     AQSTADAKKS AGDASASAAQ VAALVTDATD SARAASTSAG QAASSAQEAS SGAEAASAKA
     TEAEKSAAAA ESSKNAAATS AGAAKTSETN AAASQQSAAT SASTAATKAS EAATSARDAV
     ASKEAAKSSE TNASSSAGRA ASSATAAENS ARAAKTSETN ARSSETAAER SASAAADAKT
     AAAGSASTAS TKATEAAGSA VSASQSKSAA EAAAIRAKNS AKRAEDIASA VALEDADTTR
     KGIVQLSSAT NSTSETLAAT PKAVKVVMDE TNRKAPLDSP ALTGTPTAPT ALRGTNNTQI
     ANTAFVLAAI ADVIDASPDA LNTLNELAAA LGNDPDFATT MTNALAGKQP KNATLTALAG
     LSTAKNKLPY FAENDAASLT ELTQVGRDIL AKNSVADVLE YLGAGENSAF PAGAPIPWPS
     DIVPSGYVLM QGQAFDKSAY PKLAVAYPSG VLPDMRGWTI KGKPASGRAV LSQEQDGIKS
     HTHSASASGT DLGTKTTSSF DYGTKTTGSF DYGTKSTNNT GAHAHSLSGS TGAAGAHAHT
     SGLRMNSSGW SQYGTATITG SLSTVKGTST QGIAYLSKTD SQGSHSHSLS GTAVSAGAHA
     HTVGIGAHQH PVVIGAHAHS FSIGSHGHTI TVNAAGNAEN TVKNIAFNYI VRLA