ID   FIBIN_DANRE             Reviewed;         210 AA.
AC   A1IGX5; Q567Y0;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Fin bud initiation factor;
DE   Flags: Precursor;
GN   Name=fibin; ORFNames=zgc:110676;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND
RP   DEVELOPMENTAL STAGE.
RC   TISSUE=Embryo;
RX   PubMed=17196583; DOI=10.1016/j.ydbio.2006.11.041;
RA   Wakahara T., Kusu N., Yamauchi H., Kimura I., Konishi M., Miyake A.,
RA   Itoh N.;
RT   "Fibin, a novel secreted lateral plate mesoderm signal, is essential for
RT   pectoral fin bud initiation in zebrafish.";
RL   Dev. Biol. 303:527-535(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential for the initiation of pectoral fin bud formation.
CC       Potentially acts downstream of retinoic acid and Wnt signaling and is
CC       required for tbx5 expression in the lateral plate mesoderm of
CC       presumptive pectoral fin bud regions. {ECO:0000269|PubMed:17196583}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. Seems to also exist as monomers
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}. Secreted
CC       {ECO:0000269|PubMed:17196583}. Golgi apparatus
CC       {ECO:0000269|PubMed:17196583}.
CC   -!- DEVELOPMENTAL STAGE: First detected in the notochord at 10 hours post
CC       fertilization (hpf). At 12 and 14 hpf (the 6- and 10-somite stages),
CC       expressed in the notochord, somites and tail. At 14 hpf, also expressed
CC       in the forebrain and the lateral plate mesoderm anterior to somite 1.
CC       At 18 and 24 hpf, predominantly expressed in the tail, presumptive
CC       pectoral fin bud regions and the alar plate of the hindbrain.
CC       {ECO:0000269|PubMed:17196583}.
CC   -!- SIMILARITY: Belongs to the FIBIN family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH92975.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB236894; BAF42656.1; -; mRNA.
DR   EMBL; BC092975; AAH92975.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001017873.2; NM_001017873.2.
DR   AlphaFoldDB; A1IGX5; -.
DR   STRING; 7955.ENSDARP00000112062; -.
DR   PaxDb; A1IGX5; -.
DR   Ensembl; ENSDART00000123498; ENSDARP00000112062; ENSDARG00000087196.
DR   Ensembl; ENSDART00000187497; ENSDARP00000151620; ENSDARG00000110737.
DR   GeneID; 550571; -.
DR   KEGG; dre:550571; -.
DR   CTD; 550571; -.
DR   ZFIN; ZDB-GENE-050417-423; fibinb.
DR   eggNOG; ENOG502QSW0; Eukaryota.
DR   GeneTree; ENSGT00390000007623; -.
DR   HOGENOM; CLU_1323584_0_0_1; -.
DR   InParanoid; A1IGX5; -.
DR   OMA; GFFCHLC; -.
DR   OrthoDB; 1323802at2759; -.
DR   PhylomeDB; A1IGX5; -.
DR   TreeFam; TF331989; -.
DR   PRO; PR:A1IGX5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000087196; Expressed in tail bud paraxial mesoderm and 22 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:ZFIN.
DR   GO; GO:0035118; P:embryonic pectoral fin morphogenesis; IMP:ZFIN.
DR   InterPro; IPR026772; Fibin.
DR   PANTHER; PTHR31185; PTHR31185; 1.
DR   Pfam; PF15819; Fibin; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Developmental protein; Disulfide bond; Endoplasmic reticulum;
KW   Glycoprotein; Golgi apparatus; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..210
FT                   /note="Fin bud initiation factor"
FT                   /id="PRO_0000349214"
FT   COILED          133..157
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        35
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        57
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
FT   DISULFID        69
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   210 AA;  24229 MW;  BDDD2BB7F55DD892 CRC64;
     MGTMASPLFI LIACLLSMRV GGAFFAGPLY PEMSNGTFHH YFVPDGYYEE NDDPEKCQML
     FKMMDNRKCT LDEDQDSVIR DDFTIIKRHI EDAARVLEGI GKSISFDLDG EDSYGKYLRR
     ETTQISEAFS NSEKSLLELE VKFKQSQENE LKEEHKISDD FLNMIVHTRD VLKETLDISL
     GLKDKHELLS LIIRSHGTRL SRLKNDYMKV